A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons

Canine leishmaniasis is an important zoonosis caused by uncontrolled infection with Leishmania infantum, where an inappropriate immune response is not only responsible for permitting this intracellular parasite to multiply, but is also responsible for several of the pathological processes seen in th...

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Autores: Oliva, Gaetano, Nieto Martinez, Francisco Javier, Foglia Manzillo, Valentina, Cappiello, Silvia, Fiorentino, Eleonora, Di Muccio, Trentina, Scalone, Aldo, Moreno, Javier, Chicharro, Carmen, Carrillo, Eugenia, Butaud, Therese, Guegand, Laurie, Martin, Virginie, Cuisinier, Anne-Marie, McGahie, David, Gueguen, Sylvie, Cañavate, Carmen, Gradoni, Luigi
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/6806
Acceso en línea:http://hdl.handle.net/20.500.12105/6806
Access Level:acceso abierto
Palabra clave:Animals
Dog Diseases
Dogs
Double-Blind Method
Endemic Diseases
Female
Insect Vectors
Italy
Leishmania infantum
Leishmaniasis Vaccines
Leishmaniasis, Visceral
Male
Phlebotomus
Spain
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spelling A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasonsOliva, GaetanoNieto Martinez, Francisco JavierFoglia Manzillo, ValentinaCappiello, SilviaFiorentino, EleonoraDi Muccio, TrentinaScalone, AldoMoreno, JavierChicharro, CarmenCarrillo, EugeniaButaud, ThereseGuegand, LaurieMartin, VirginieCuisinier, Anne-MarieMcGahie, DavidGueguen, SylvieCañavate, CarmenGradoni, LuigiAnimalsDog DiseasesDogsDouble-Blind MethodEndemic DiseasesFemaleInsect VectorsItalyLeishmania infantumLeishmaniasis VaccinesLeishmaniasis, VisceralMalePhlebotomusSpainCanine leishmaniasis is an important zoonosis caused by uncontrolled infection with Leishmania infantum, where an inappropriate immune response is not only responsible for permitting this intracellular parasite to multiply, but is also responsible for several of the pathological processes seen in this disease. Effective canine vaccines are therefore a highly desirable prevention tool. In this randomised, double-blinded, controlled trial, the efficacy of the LiESP/QA-21 vaccine (CaniLeish, Virbac, France) was assessed by exposing 90 naïve dogs to natural L. infantum infection during 2 consecutive transmission seasons, in two highly endemic areas of the Mediterranean basin. Regular PCR, culture, serological and clinical examinations were performed, and the infection/disease status of the dogs was classified at each examination. The vaccine was well-tolerated, and provided a significant reduction in the risk of progressing to uncontrolled active infection (p = 0.025) or symptomatic disease (p = 0.046), with an efficacy of 68.4% and a protection rate of 92.7%. The probability of becoming PCR positive was similar between groups, but the probability of returning to a PCR negative condition was higher in the vaccinated group (p = 0.04). In conclusion, we confirmed the interest of using this vaccine as part of a comprehensive control program for canine leishmaniasis, and validated the use of a protocol based on regular in-depth assessments over time to assess the efficacy of a canine leishmaniasis vaccine.Public Library of Science (PLOS)Virbac (France)20182018-12-1120142014-10-0920142014-10-09journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/6806reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/68062026-06-12T12:43:37Z
dc.title.none.fl_str_mv A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons
title A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons
spellingShingle A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons
Oliva, Gaetano
Animals
Dog Diseases
Dogs
Double-Blind Method
Endemic Diseases
Female
Insect Vectors
Italy
Leishmania infantum
Leishmaniasis Vaccines
Leishmaniasis, Visceral
Male
Phlebotomus
Spain
title_short A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons
title_full A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons
title_fullStr A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons
title_full_unstemmed A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons
title_sort A randomised, double-blind, controlled efficacy trial of the LiESP/QA-21 vaccine in naïve dogs exposed to two leishmania infantum transmission seasons
dc.creator.none.fl_str_mv Oliva, Gaetano
Nieto Martinez, Francisco Javier
Foglia Manzillo, Valentina
Cappiello, Silvia
Fiorentino, Eleonora
Di Muccio, Trentina
Scalone, Aldo
Moreno, Javier
Chicharro, Carmen
Carrillo, Eugenia
Butaud, Therese
Guegand, Laurie
Martin, Virginie
Cuisinier, Anne-Marie
McGahie, David
Gueguen, Sylvie
Cañavate, Carmen
Gradoni, Luigi
author Oliva, Gaetano
author_facet Oliva, Gaetano
Nieto Martinez, Francisco Javier
Foglia Manzillo, Valentina
Cappiello, Silvia
Fiorentino, Eleonora
Di Muccio, Trentina
Scalone, Aldo
Moreno, Javier
Chicharro, Carmen
Carrillo, Eugenia
Butaud, Therese
Guegand, Laurie
Martin, Virginie
Cuisinier, Anne-Marie
McGahie, David
Gueguen, Sylvie
Cañavate, Carmen
Gradoni, Luigi
author_role author
author2 Nieto Martinez, Francisco Javier
Foglia Manzillo, Valentina
Cappiello, Silvia
Fiorentino, Eleonora
Di Muccio, Trentina
Scalone, Aldo
Moreno, Javier
Chicharro, Carmen
Carrillo, Eugenia
Butaud, Therese
Guegand, Laurie
Martin, Virginie
Cuisinier, Anne-Marie
McGahie, David
Gueguen, Sylvie
Cañavate, Carmen
Gradoni, Luigi
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Virbac (France)
dc.subject.none.fl_str_mv Animals
Dog Diseases
Dogs
Double-Blind Method
Endemic Diseases
Female
Insect Vectors
Italy
Leishmania infantum
Leishmaniasis Vaccines
Leishmaniasis, Visceral
Male
Phlebotomus
Spain
topic Animals
Dog Diseases
Dogs
Double-Blind Method
Endemic Diseases
Female
Insect Vectors
Italy
Leishmania infantum
Leishmaniasis Vaccines
Leishmaniasis, Visceral
Male
Phlebotomus
Spain
description Canine leishmaniasis is an important zoonosis caused by uncontrolled infection with Leishmania infantum, where an inappropriate immune response is not only responsible for permitting this intracellular parasite to multiply, but is also responsible for several of the pathological processes seen in this disease. Effective canine vaccines are therefore a highly desirable prevention tool. In this randomised, double-blinded, controlled trial, the efficacy of the LiESP/QA-21 vaccine (CaniLeish, Virbac, France) was assessed by exposing 90 naïve dogs to natural L. infantum infection during 2 consecutive transmission seasons, in two highly endemic areas of the Mediterranean basin. Regular PCR, culture, serological and clinical examinations were performed, and the infection/disease status of the dogs was classified at each examination. The vaccine was well-tolerated, and provided a significant reduction in the risk of progressing to uncontrolled active infection (p = 0.025) or symptomatic disease (p = 0.046), with an efficacy of 68.4% and a protection rate of 92.7%. The probability of becoming PCR positive was similar between groups, but the probability of returning to a PCR negative condition was higher in the vaccinated group (p = 0.04). In conclusion, we confirmed the interest of using this vaccine as part of a comprehensive control program for canine leishmaniasis, and validated the use of a protocol based on regular in-depth assessments over time to assess the efficacy of a canine leishmaniasis vaccine.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-10-09
2014
2014-10-09
2018
2018-12-11
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/6806
url http://hdl.handle.net/20.500.12105/6806
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLOS)
publisher.none.fl_str_mv Public Library of Science (PLOS)
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411015112785920
score 15.812455

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