Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome

Objectives: To construct a prediction model of preference-adjusted health status (SF-6D) for Cushing's syndrome using a disease-specific health-related quality of life (HRQOL) measure (CushingQoL). Methods: Data were obtained from the original multicenter, multinational study to validate the Cu...

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Autores: Roset, Montse|||0000-0002-4641-9814, Badia, Xavier|||0000-0001-7568-2550, Forsythe, Anna, Webb, Susan|||0000-0001-7052-6436
Tipo de recurso: artículo
Fecha de publicación:2013
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:303521
Acceso en línea:https://ddd.uab.cat/record/303521
https://dx.doi.org/urn:doi:10.1007/s40271-013-0010-7
Access Level:acceso abierto
Palabra clave:Adrenal Adenoma
HRQOL Instrument
Irritable Bowel Syndrome
Mapping Exercise
Root Mean Square Error
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spelling Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndromeRoset, Montse|||0000-0002-4641-9814Badia, Xavier|||0000-0001-7568-2550Forsythe, AnnaWebb, Susan|||0000-0001-7052-6436Adrenal AdenomaHRQOL InstrumentIrritable Bowel SyndromeMapping ExerciseRoot Mean Square ErrorObjectives: To construct a prediction model of preference-adjusted health status (SF-6D) for Cushing's syndrome using a disease-specific health-related quality of life (HRQOL) measure (CushingQoL). Methods: Data were obtained from the original multicenter, multinational study to validate the CushingQoL questionnaire. HRQOL was measured using the CushingQoL and the SF-36 questionnaires. SF-6D scores were calculated from responses on the SF-36. Sociodemographic and clinical data were also collected. Various predictive models were tested and the final one was selected on the basis of four criteria: explanatory power, consistency of estimated coefficients, normality of prediction errors, and parsimony. Results: For the mapping analysis, data were available from 116 of the 125 patients included in the original validation study. Mean (SD) age was 45.3 (13.1) years and the sample was predominantly (83 %) female. Patients had a mean (SD) CushingQoL score of 52.9 (21.9), whereas the SF-6D (derived from SF-36) was skewed towards better health with a mean of 0.71 (median 0.74) on a scale of -0.704 to 1. Of the various models tested, a model which included the intercept (0.61), CushingQoL overall score, level one in CushingQoL item 2 (always have pain preventing me from leading a normal life), and level one in CushingQoL item 10 (my illness always affects my everyday activities) best met the four criteria for model selection. The model had an adjusted R of 0.60 and a root mean square error of 0.084. Conclusions: Although the mapping function finally selected appears to be able to accurately map CushingQoL scores onto SF-6D outcomes at the group level, further testing is required to validate the model in independent patient samples. © 2013 The Author(s).Universitat Autònoma de Barcelona. Departament de Medicina 22013-01-0120132013-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/303521https://dx.doi.org/urn:doi:10.1007/s40271-013-0010-7reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3035212026-06-06T12:50:31Z
dc.title.none.fl_str_mv Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome
title Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome
spellingShingle Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome
Roset, Montse|||0000-0002-4641-9814
Adrenal Adenoma
HRQOL Instrument
Irritable Bowel Syndrome
Mapping Exercise
Root Mean Square Error
title_short Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome
title_full Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome
title_fullStr Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome
title_full_unstemmed Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome
title_sort Mapping CushingQoL scores onto SF-6D utility values in patients with Cushing's syndrome
dc.creator.none.fl_str_mv Roset, Montse|||0000-0002-4641-9814
Badia, Xavier|||0000-0001-7568-2550
Forsythe, Anna
Webb, Susan|||0000-0001-7052-6436
author Roset, Montse|||0000-0002-4641-9814
author_facet Roset, Montse|||0000-0002-4641-9814
Badia, Xavier|||0000-0001-7568-2550
Forsythe, Anna
Webb, Susan|||0000-0001-7052-6436
author_role author
author2 Badia, Xavier|||0000-0001-7568-2550
Forsythe, Anna
Webb, Susan|||0000-0001-7052-6436
author2_role author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona. Departament de Medicina
dc.subject.none.fl_str_mv Adrenal Adenoma
HRQOL Instrument
Irritable Bowel Syndrome
Mapping Exercise
Root Mean Square Error
topic Adrenal Adenoma
HRQOL Instrument
Irritable Bowel Syndrome
Mapping Exercise
Root Mean Square Error
description Objectives: To construct a prediction model of preference-adjusted health status (SF-6D) for Cushing's syndrome using a disease-specific health-related quality of life (HRQOL) measure (CushingQoL). Methods: Data were obtained from the original multicenter, multinational study to validate the CushingQoL questionnaire. HRQOL was measured using the CushingQoL and the SF-36 questionnaires. SF-6D scores were calculated from responses on the SF-36. Sociodemographic and clinical data were also collected. Various predictive models were tested and the final one was selected on the basis of four criteria: explanatory power, consistency of estimated coefficients, normality of prediction errors, and parsimony. Results: For the mapping analysis, data were available from 116 of the 125 patients included in the original validation study. Mean (SD) age was 45.3 (13.1) years and the sample was predominantly (83 %) female. Patients had a mean (SD) CushingQoL score of 52.9 (21.9), whereas the SF-6D (derived from SF-36) was skewed towards better health with a mean of 0.71 (median 0.74) on a scale of -0.704 to 1. Of the various models tested, a model which included the intercept (0.61), CushingQoL overall score, level one in CushingQoL item 2 (always have pain preventing me from leading a normal life), and level one in CushingQoL item 10 (my illness always affects my everyday activities) best met the four criteria for model selection. The model had an adjusted R of 0.60 and a root mean square error of 0.084. Conclusions: Although the mapping function finally selected appears to be able to accurately map CushingQoL scores onto SF-6D outcomes at the group level, further testing is required to validate the model in independent patient samples. © 2013 The Author(s).
publishDate 2013
dc.date.none.fl_str_mv 2
2013-01-01
2013
2013-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/303521
https://dx.doi.org/urn:doi:10.1007/s40271-013-0010-7
url https://ddd.uab.cat/record/303521
https://dx.doi.org/urn:doi:10.1007/s40271-013-0010-7
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
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rights_invalid_str_mv open access
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eu_rights_str_mv openAccess
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dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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