Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona

Zika virus (ZIKV) is a vector-borne flavivirus with a known teratogenic effect, yet the full spectrum has not been delineated. Studies on endemic areas tried to characterize the clinical outcomes of ZIKV intrauterine exposure. We aimed to describe early neurodevelopmental outcomes on prenatally ZIKV...

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Autores: Romaní, Natàlia, Pieras, Maria, Frick, Marie Antoinette|||0000-0002-2553-5090, Sulleiro, Elena|||0000-0002-9783-6060, Rodó, Carlota|||0000-0001-8801-5677, Silgado, Aroa|||0000-0001-7581-0049, Suy, Anna|||0000-0003-2987-6105, Espiau, María|||0000-0001-9697-7649, Thorne, C.|||0000-0003-0389-1956, Giaquinto, C., Felipe-Rucián, Ana|||0000-0002-5267-1370, Soler-Palacín, Pere|||0000-0002-0346-5570, Soriano-Arandes, Antoni|||0000-0001-9613-7228
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:292096
Acceso en línea:https://ddd.uab.cat/record/292096
https://dx.doi.org/urn:doi:10.3390/children9101537
Access Level:acceso abierto
Palabra clave:Adverse outcome
Arboviruses
Children
Congenital infection
Microcephaly
Mother-to-child transmission
Neonate
Travel-associated
Zika virus
Zika virus infection
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spelling Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in BarcelonaRomaní, NatàliaPieras, MariaFrick, Marie Antoinette|||0000-0002-2553-5090Sulleiro, Elena|||0000-0002-9783-6060Rodó, Carlota|||0000-0001-8801-5677Silgado, Aroa|||0000-0001-7581-0049Suy, Anna|||0000-0003-2987-6105Espiau, María|||0000-0001-9697-7649Thorne, C.|||0000-0003-0389-1956Giaquinto, C.Felipe-Rucián, Ana|||0000-0002-5267-1370Soler-Palacín, Pere|||0000-0002-0346-5570Soriano-Arandes, Antoni|||0000-0001-9613-7228Adverse outcomeArbovirusesChildrenCongenital infectionMicrocephalyMother-to-child transmissionNeonateTravel-associatedZika virusZika virus infectionZika virus (ZIKV) is a vector-borne flavivirus with a known teratogenic effect, yet the full spectrum has not been delineated. Studies on endemic areas tried to characterize the clinical outcomes of ZIKV intrauterine exposure. We aimed to describe early neurodevelopmental outcomes on prenatally ZIKV-exposed children in a non-endemic ZIKV area. This is a prospective observational cohort study conducted from May 2016 to December 2021 at Hospital Universitari Vall d'Hebron in Barcelona, Catalonia, Spain. We monitored for up to 24 months 152 children extracted from a pregnant women cohort with suspected ZIKV infection; eleven women (11/150; 7.3%) fulfilled the criteria for a confirmed ZIKV infection. Among the 152 children included, we describe two cases of congenital ZIKV syndrome (CZS) born from women with a confirmed ZIKV infection. Additionally, we describe five cases of other potentially ZIKV-related outcomes (OPZROs), all with normal birth cranial circumference and born to women with probable ZIKV infection. The low exposed prevalence of adverse outcomes in asymptomatic children at birth in a non-endemic area suggests that close follow-up should be addressed by primary care pediatricians instead of pediatric specialists. Further studies are needed to assess the effects of ZIKV intrauterine exposure beyond two years of life.Universitat Autònoma de Barcelona 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/292096https://dx.doi.org/urn:doi:10.3390/children9101537reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengEuropean Commission https://doi.org/10.13039/501100000780 734857open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2920962026-06-06T12:50:31Z
dc.title.none.fl_str_mv Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
title Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
spellingShingle Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
Romaní, Natàlia
Adverse outcome
Arboviruses
Children
Congenital infection
Microcephaly
Mother-to-child transmission
Neonate
Travel-associated
Zika virus
Zika virus infection
title_short Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
title_full Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
title_fullStr Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
title_full_unstemmed Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
title_sort Neurological Short-Term Outcomes of a Cohort of Children Born to Zika Virus-Infected Mothers in Barcelona
dc.creator.none.fl_str_mv Romaní, Natàlia
Pieras, Maria
Frick, Marie Antoinette|||0000-0002-2553-5090
Sulleiro, Elena|||0000-0002-9783-6060
Rodó, Carlota|||0000-0001-8801-5677
Silgado, Aroa|||0000-0001-7581-0049
Suy, Anna|||0000-0003-2987-6105
Espiau, María|||0000-0001-9697-7649
Thorne, C.|||0000-0003-0389-1956
Giaquinto, C.
Felipe-Rucián, Ana|||0000-0002-5267-1370
Soler-Palacín, Pere|||0000-0002-0346-5570
Soriano-Arandes, Antoni|||0000-0001-9613-7228
author Romaní, Natàlia
author_facet Romaní, Natàlia
Pieras, Maria
Frick, Marie Antoinette|||0000-0002-2553-5090
Sulleiro, Elena|||0000-0002-9783-6060
Rodó, Carlota|||0000-0001-8801-5677
Silgado, Aroa|||0000-0001-7581-0049
Suy, Anna|||0000-0003-2987-6105
Espiau, María|||0000-0001-9697-7649
Thorne, C.|||0000-0003-0389-1956
Giaquinto, C.
Felipe-Rucián, Ana|||0000-0002-5267-1370
Soler-Palacín, Pere|||0000-0002-0346-5570
Soriano-Arandes, Antoni|||0000-0001-9613-7228
author_role author
author2 Pieras, Maria
Frick, Marie Antoinette|||0000-0002-2553-5090
Sulleiro, Elena|||0000-0002-9783-6060
Rodó, Carlota|||0000-0001-8801-5677
Silgado, Aroa|||0000-0001-7581-0049
Suy, Anna|||0000-0003-2987-6105
Espiau, María|||0000-0001-9697-7649
Thorne, C.|||0000-0003-0389-1956
Giaquinto, C.
Felipe-Rucián, Ana|||0000-0002-5267-1370
Soler-Palacín, Pere|||0000-0002-0346-5570
Soriano-Arandes, Antoni|||0000-0001-9613-7228
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Adverse outcome
Arboviruses
Children
Congenital infection
Microcephaly
Mother-to-child transmission
Neonate
Travel-associated
Zika virus
Zika virus infection
topic Adverse outcome
Arboviruses
Children
Congenital infection
Microcephaly
Mother-to-child transmission
Neonate
Travel-associated
Zika virus
Zika virus infection
description Zika virus (ZIKV) is a vector-borne flavivirus with a known teratogenic effect, yet the full spectrum has not been delineated. Studies on endemic areas tried to characterize the clinical outcomes of ZIKV intrauterine exposure. We aimed to describe early neurodevelopmental outcomes on prenatally ZIKV-exposed children in a non-endemic ZIKV area. This is a prospective observational cohort study conducted from May 2016 to December 2021 at Hospital Universitari Vall d'Hebron in Barcelona, Catalonia, Spain. We monitored for up to 24 months 152 children extracted from a pregnant women cohort with suspected ZIKV infection; eleven women (11/150; 7.3%) fulfilled the criteria for a confirmed ZIKV infection. Among the 152 children included, we describe two cases of congenital ZIKV syndrome (CZS) born from women with a confirmed ZIKV infection. Additionally, we describe five cases of other potentially ZIKV-related outcomes (OPZROs), all with normal birth cranial circumference and born to women with probable ZIKV infection. The low exposed prevalence of adverse outcomes in asymptomatic children at birth in a non-endemic area suggests that close follow-up should be addressed by primary care pediatricians instead of pediatric specialists. Further studies are needed to assess the effects of ZIKV intrauterine exposure beyond two years of life.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/292096
https://dx.doi.org/urn:doi:10.3390/children9101537
url https://ddd.uab.cat/record/292096
https://dx.doi.org/urn:doi:10.3390/children9101537
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv European Commission https://doi.org/10.13039/501100000780 734857
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,301603

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