Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?

Of the diverse array of putative molecular and biological functions assigned to long non-coding RNAs (lncRNAs), one attractive perspective in epigenetic research has been the hypothesis that lncRNAs directly interact with the proteins involved in the modulation of chromatin conformation. Indeed, epi...

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Detalles Bibliográficos
Autores: Hanly, David J., Esteller, Manel, Berdasco, María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/172441
Acceso en línea:https://hdl.handle.net/2445/172441
Access Level:acceso abierto
Palabra clave:Càncer
Epigenètica
Cancer
Epigenetics
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spelling Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?Hanly, David J.Esteller, ManelBerdasco, MaríaCàncerEpigenèticaCancerEpigeneticsOf the diverse array of putative molecular and biological functions assigned to long non-coding RNAs (lncRNAs), one attractive perspective in epigenetic research has been the hypothesis that lncRNAs directly interact with the proteins involved in the modulation of chromatin conformation. Indeed, epigenetic modifiers are among the most frequent protein partners of lncRNAs that have been identified to date, of which histone methyltransferases and protein members of the Polycomb Repressive Complex PRC2 have received considerable attention. This review is focused on how lncRNAs interface with epigenetic factors to shape the outcomes of crucial biological processes such as regulation of gene transcription, modulation of nuclear architecture, X inactivation in females and pre-mRNA splicing. Because of our increasing knowledge of their role in development and cellular differentiation, more research is beginning to be done into the deregulation of lncRNAs in human disorders. Focusing on cancer, we describe some key examples of disease-focused lncRNA studies. This knowledge has significantly contributed to our ever-improving understanding of how lncRNAs interact with epigenetic factors of human disease, and has also provided a plethora of much-needed novel prognostic biomarker candidates or potential therapeutic targets. Finally, current limitations and perspectives on lncRNA research are discussed here. This article is part of a discussion meeting issue 'Frontiers in epigenetic chemical biology'.Royal Society2020202020182020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion11 p.application/pdfhttps://hdl.handle.net/2445/172441Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1098/rstb.2017.0074Philosophical Transactions of The Royal Society B. Biological Sciences, 2018, vol. 373, num. 1748, p. 20170074https://doi.org/10.1098/rstb.2017.0074info:eu-repo/grantAgreement/EC/H2020/642934cc by (c) Hanly et al., 2018http://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1724412026-05-29T05:05:01Z
dc.title.none.fl_str_mv Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?
title Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?
spellingShingle Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?
Hanly, David J.
Càncer
Epigenètica
Cancer
Epigenetics
title_short Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?
title_full Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?
title_fullStr Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?
title_full_unstemmed Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?
title_sort Interplay between long non-coding RNAs and epigenetic machinery: emerging targets in cancer?
dc.creator.none.fl_str_mv Hanly, David J.
Esteller, Manel
Berdasco, María
author Hanly, David J.
author_facet Hanly, David J.
Esteller, Manel
Berdasco, María
author_role author
author2 Esteller, Manel
Berdasco, María
author2_role author
author
dc.subject.none.fl_str_mv Càncer
Epigenètica
Cancer
Epigenetics
topic Càncer
Epigenètica
Cancer
Epigenetics
description Of the diverse array of putative molecular and biological functions assigned to long non-coding RNAs (lncRNAs), one attractive perspective in epigenetic research has been the hypothesis that lncRNAs directly interact with the proteins involved in the modulation of chromatin conformation. Indeed, epigenetic modifiers are among the most frequent protein partners of lncRNAs that have been identified to date, of which histone methyltransferases and protein members of the Polycomb Repressive Complex PRC2 have received considerable attention. This review is focused on how lncRNAs interface with epigenetic factors to shape the outcomes of crucial biological processes such as regulation of gene transcription, modulation of nuclear architecture, X inactivation in females and pre-mRNA splicing. Because of our increasing knowledge of their role in development and cellular differentiation, more research is beginning to be done into the deregulation of lncRNAs in human disorders. Focusing on cancer, we describe some key examples of disease-focused lncRNA studies. This knowledge has significantly contributed to our ever-improving understanding of how lncRNAs interact with epigenetic factors of human disease, and has also provided a plethora of much-needed novel prognostic biomarker candidates or potential therapeutic targets. Finally, current limitations and perspectives on lncRNA research are discussed here. This article is part of a discussion meeting issue 'Frontiers in epigenetic chemical biology'.
publishDate 2018
dc.date.none.fl_str_mv 2018
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/172441
url https://hdl.handle.net/2445/172441
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1098/rstb.2017.0074
Philosophical Transactions of The Royal Society B. Biological Sciences, 2018, vol. 373, num. 1748, p. 20170074
https://doi.org/10.1098/rstb.2017.0074
info:eu-repo/grantAgreement/EC/H2020/642934
dc.rights.none.fl_str_mv cc by (c) Hanly et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by (c) Hanly et al., 2018
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 11 p.
application/pdf
dc.publisher.none.fl_str_mv Royal Society
publisher.none.fl_str_mv Royal Society
dc.source.none.fl_str_mv Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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