EGFR and KRAS Mutations in the Non-Tumoral Lung. Prognosis in Patients with Adenocarcinoma

Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout the exposed lung. Objective: To analyze whether the most prevalent mutatio...

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Detalles Bibliográficos
Autores: Chalela, Roberto|||0000-0003-4835-3852, Bellosillo Paricio, Beatriz|||0000-0002-5335-2726, Curull Serrano, Víctor|||0000-0003-2709-7431, Longarón, Raquel, Pascual-Guardia, Sergi|||0000-0002-6567-0916, Badenes-Bonet, Diana|||0000-0001-8034-0838, Arriola, Edurne|||0000-0001-8960-7519, Sánchez Font, Albert|||0000-0003-1026-7908, Pijuan, Lara|||0000-0002-9978-6933, Gea Guiral, Joaquim|||0000-0001-8718-7346
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253279
Acceso en línea:https://ddd.uab.cat/record/253279
https://dx.doi.org/urn:doi:10.3390/jcm8040529
Access Level:acceso abierto
Palabra clave:Adenocarcinoma
Mutations
EGFR
KRAS
Prognosis
Descripción
Sumario:Tumor recurrence is frequent and survival rates remain extremely low in lung adenocarcinoma (ADC). We hypothesize that carcinogenic factors will promote loco-regional modifications not only in the future tumor, but throughout the exposed lung. Objective: To analyze whether the most prevalent mutations observed in ADC can also be observed in the non-neoplastic lung tissue, as well as the short-term prognosis implications of this finding. Methods: Non-tumoral lung parenchyma specimens obtained during surgery from 47 patients with EGFR and/or KRAS abnormalities in their ADC tumors underwent similar genomic testing. Short-term outcomes were also recorded. Results: The same mutations were present in the tumor and the histologically normal tissue in 21.3% of patients (SM group). Although local recurrences were similar in both groups, distant metastases were more frequent in the former (60 vs. 5.4%, p < 0.001). Moreover, SM patients showed lower time-to-progression (8.5 vs. 11.7 months, p < 0.001) and disease-free survival (8.5 vs. 11.2 months, p < 0.001). COX regression showed a higher risk of progression or death (DFS) in the SM group (HR 5.94, p < 0.01]. Similar results were observed when adjusting for potential confounding variables. Conclusions: These results confirm that genetic changes are present in the apparently normal lung in many ADC patients, and this finding has prognostic implications.

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