Absorption and metabolism of yerba mate phenolic compounds in humans

Bioavailability of yerba mate phenolic compounds was assessed in healthy humans. More than 34 metabolites were identified in biological fluids, mainly sulfated conjugates of caffeic and ferulic/isoferulic acids, in addition to non-metabolized caffeoyl-, feruloyl- and p-coumaroilquinic acids, with ra...

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Detalles Bibliográficos
Autores: Gómez Juaristi, Miren, Martínez López, Sara, Sarriá, Beatriz, Bravo-Clemente, Laura, Mateos, Raquel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/170810
Acceso en línea:http://hdl.handle.net/10261/170810
Access Level:acceso abierto
Palabra clave:Hydroxycinnamate derivatives
Flavonols
Bioavailability
Colonic microbiota
LC-MS-QToF
Yerba mate
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spelling Absorption and metabolism of yerba mate phenolic compounds in humansGómez Juaristi, MirenMartínez López, SaraSarriá, BeatrizBravo-Clemente, LauraMateos, RaquelHydroxycinnamate derivativesFlavonolsBioavailabilityColonic microbiotaLC-MS-QToFYerba mateBioavailability of yerba mate phenolic compounds was assessed in healthy humans. More than 34 metabolites were identified in biological fluids, mainly sulfated conjugates of caffeic and ferulic/isoferulic acids, in addition to non-metabolized caffeoyl-, feruloyl- and p-coumaroilquinic acids, with rapid appearance and clearance in plasma indicative of small intestinal absorption. These compounds amounted to 13.1% of the urinary metabolites. Delayed absorption of dihydrocaffeic, dihydroferulic and dihydrocoumaric acids and their phase II metabolites, in addition to feruloylglycine, pointed to their microbial origin and colonic absorption, accounting for 81.0% of excreted metabolites. Phase II flavonol metabolites (0.2%) derived mainly from rutin after colonic transformation and absorption were also detected. Additionally, dihydroferuloyl-, dihydrocaffeoyl- and dihydrocoumaroylquinic acids (5.7%) were identified, showing the most delayed kinetics. Total phenolic excretion (147.6 μmol) corresponded to 13.2% of ingested phenols. In conclusion, yerba mate polyphenols are partially bioavailable and extensively metabolized, mainly by the colonic microbiota.We also are grateful to the Spanish Ministry of Economy and Competitivity (MINECO-FEDER) for financial support (projects AGL2010-18269 and AGL2015-69986-R). S.M.-L. was a predoctoral fellow of the JAE Program (JAEPre097) co-funded by CSIC and the European Social Fund. M. G.-J. was a predoctoral FPI fellow (BES2008-007138) of the Spanish Ministry of Science and Innovation.Peer ReviewedElsevierMinisterio de Ciencia e Innovación (España)Consejo Superior de Investigaciones Científicas (España)European CommissionMinisterio de Economía y Competitividad (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820182018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Postprintinfo:eu-repo/semantics/acceptedVersionhttp://hdl.handle.net/10261/170810reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-69986-Rhttps://doi.org/10.1016/j.foodchem.2017.08.003Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1708102026-05-22T06:33:51Z
dc.title.none.fl_str_mv Absorption and metabolism of yerba mate phenolic compounds in humans
title Absorption and metabolism of yerba mate phenolic compounds in humans
spellingShingle Absorption and metabolism of yerba mate phenolic compounds in humans
Gómez Juaristi, Miren
Hydroxycinnamate derivatives
Flavonols
Bioavailability
Colonic microbiota
LC-MS-QToF
Yerba mate
title_short Absorption and metabolism of yerba mate phenolic compounds in humans
title_full Absorption and metabolism of yerba mate phenolic compounds in humans
title_fullStr Absorption and metabolism of yerba mate phenolic compounds in humans
title_full_unstemmed Absorption and metabolism of yerba mate phenolic compounds in humans
title_sort Absorption and metabolism of yerba mate phenolic compounds in humans
dc.creator.none.fl_str_mv Gómez Juaristi, Miren
Martínez López, Sara
Sarriá, Beatriz
Bravo-Clemente, Laura
Mateos, Raquel
author Gómez Juaristi, Miren
author_facet Gómez Juaristi, Miren
Martínez López, Sara
Sarriá, Beatriz
Bravo-Clemente, Laura
Mateos, Raquel
author_role author
author2 Martínez López, Sara
Sarriá, Beatriz
Bravo-Clemente, Laura
Mateos, Raquel
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Ciencia e Innovación (España)
Consejo Superior de Investigaciones Científicas (España)
European Commission
Ministerio de Economía y Competitividad (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Hydroxycinnamate derivatives
Flavonols
Bioavailability
Colonic microbiota
LC-MS-QToF
Yerba mate
topic Hydroxycinnamate derivatives
Flavonols
Bioavailability
Colonic microbiota
LC-MS-QToF
Yerba mate
description Bioavailability of yerba mate phenolic compounds was assessed in healthy humans. More than 34 metabolites were identified in biological fluids, mainly sulfated conjugates of caffeic and ferulic/isoferulic acids, in addition to non-metabolized caffeoyl-, feruloyl- and p-coumaroilquinic acids, with rapid appearance and clearance in plasma indicative of small intestinal absorption. These compounds amounted to 13.1% of the urinary metabolites. Delayed absorption of dihydrocaffeic, dihydroferulic and dihydrocoumaric acids and their phase II metabolites, in addition to feruloylglycine, pointed to their microbial origin and colonic absorption, accounting for 81.0% of excreted metabolites. Phase II flavonol metabolites (0.2%) derived mainly from rutin after colonic transformation and absorption were also detected. Additionally, dihydroferuloyl-, dihydrocaffeoyl- and dihydrocoumaroylquinic acids (5.7%) were identified, showing the most delayed kinetics. Total phenolic excretion (147.6 μmol) corresponded to 13.2% of ingested phenols. In conclusion, yerba mate polyphenols are partially bioavailable and extensively metabolized, mainly by the colonic microbiota.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Postprint
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/170810
url http://hdl.handle.net/10261/170810
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/AGL2015-69986-R
https://doi.org/10.1016/j.foodchem.2017.08.003
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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