Hepatitis G virus infection in chronic liver disease
Background¿The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims¿To evaluate the prevalence and meaning of HGV infection in a large series of patients wit...
| Autores: | , , , , , , , , , , |
|---|---|
| Tipo de documento: | artigo |
| Estado: | Versão publicada |
| Data de publicação: | 1998 |
| País: | España |
| Recursos: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositório: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/18664 |
| Acesso em linha: | https://hdl.handle.net/2445/18664 |
| Access Level: | Acceso aberto |
| Palavra-chave: | GB virus C Hepatitis vírica Malalties cròniques GB virus C (GBV-C) Viral hepatitis Chronic diseases |
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Hepatitis G virus infection in chronic liver diseaseGuilera Sardà, MagdaSáiz Calahorra, Juan CarlosLópez Labrador, Francesc XavierOlmedo Casas, EvaAmpurdanés, SergiForns, XavierBruix Tudó, JordiParés Darnaculleta, AlbertSánchez Tapias, José M. (José María)Jiménez de Anta Losada, María TeresaRodés, J.GB virus CHepatitis víricaMalalties cròniquesGB virus C (GBV-C)Viral hepatitisChronic diseasesBackground¿The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims¿To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects¿Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods¿HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5¿ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results¿The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions¿The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease.BMJ Group201120111998info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5 p.application/pdfhttps://hdl.handle.net/2445/18664Articles publicats en revistes (Medicina)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.42.1.107Gut, 1998, vol. 42, núm. 1, p. 107-111http://dx.doi.org/10.1136/gut.42.1.107(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1998info:eu-repo/semantics/openAccessoai:recercat.cat:2445/186642026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Hepatitis G virus infection in chronic liver disease |
| title |
Hepatitis G virus infection in chronic liver disease |
| spellingShingle |
Hepatitis G virus infection in chronic liver disease Guilera Sardà, Magda GB virus C Hepatitis vírica Malalties cròniques GB virus C (GBV-C) Viral hepatitis Chronic diseases |
| title_short |
Hepatitis G virus infection in chronic liver disease |
| title_full |
Hepatitis G virus infection in chronic liver disease |
| title_fullStr |
Hepatitis G virus infection in chronic liver disease |
| title_full_unstemmed |
Hepatitis G virus infection in chronic liver disease |
| title_sort |
Hepatitis G virus infection in chronic liver disease |
| dc.creator.none.fl_str_mv |
Guilera Sardà, Magda Sáiz Calahorra, Juan Carlos López Labrador, Francesc Xavier Olmedo Casas, Eva Ampurdanés, Sergi Forns, Xavier Bruix Tudó, Jordi Parés Darnaculleta, Albert Sánchez Tapias, José M. (José María) Jiménez de Anta Losada, María Teresa Rodés, J. |
| author |
Guilera Sardà, Magda |
| author_facet |
Guilera Sardà, Magda Sáiz Calahorra, Juan Carlos López Labrador, Francesc Xavier Olmedo Casas, Eva Ampurdanés, Sergi Forns, Xavier Bruix Tudó, Jordi Parés Darnaculleta, Albert Sánchez Tapias, José M. (José María) Jiménez de Anta Losada, María Teresa Rodés, J. |
| author_role |
author |
| author2 |
Sáiz Calahorra, Juan Carlos López Labrador, Francesc Xavier Olmedo Casas, Eva Ampurdanés, Sergi Forns, Xavier Bruix Tudó, Jordi Parés Darnaculleta, Albert Sánchez Tapias, José M. (José María) Jiménez de Anta Losada, María Teresa Rodés, J. |
| author2_role |
author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
GB virus C Hepatitis vírica Malalties cròniques GB virus C (GBV-C) Viral hepatitis Chronic diseases |
| topic |
GB virus C Hepatitis vírica Malalties cròniques GB virus C (GBV-C) Viral hepatitis Chronic diseases |
| description |
Background¿The hepatitis G virus (HGV), a recently identified member of the Flaviviridae family, can cause chronic infection in man but the role of this agent in chronic liver disease is poorly understood. Aims¿To evaluate the prevalence and meaning of HGV infection in a large series of patients with chronic liver disease. Subjects¿Two hundred volunteer blood donors, 179 patients with chronic hepatitis C, 111 with chronic hepatitis B, 104 with alcoholic liver disease, 136 with hepatocellular carcinoma, and 24 with cryptogenic chronic liver disease were studied. Methods¿HGV RNA was investigated in serum samples by reverse transcription and polymerase chain reaction amplification of the 5¿ non-coding region of HCV and hybridisation to a specific probe. The main features of HGV RNA seropositive and seronegative patients were compared. Results¿The prevalence of HGV infection was 3% in blood donors, 7% in chronic hepatitis C, 8% in chronic hepatitis B, 2% in alcoholic liver disease, 4% in hepatocellular carcinoma, and 8% in cryptogenic chronic liver disease. HGV infected patients tended to be younger than non-infected patients but no differences concerning sex, possible source of infection, clinical manifestations, biochemical and virological parameters, or severity of liver lesions were found. Conclusions¿The prevalence of HGV infection in chronic liver disease seems to be relatively low in our area. Infection with HGV does not seem to play a significant pathogenic role in patients with chronic liver disease related to chronic HBV or HCV infection or to increased alcohol consumption, or in those with cryptogenic chronic liver disease. |
| publishDate |
1998 |
| dc.date.none.fl_str_mv |
1998 2011 2011 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://hdl.handle.net/2445/18664 |
| url |
https://hdl.handle.net/2445/18664 |
| dc.language.none.fl_str_mv |
Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Reproducció digital del document publicat a: http://dx.doi.org/10.1136/gut.42.1.107 Gut, 1998, vol. 42, núm. 1, p. 107-111 http://dx.doi.org/10.1136/gut.42.1.107 |
| dc.rights.none.fl_str_mv |
(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1998 info:eu-repo/semantics/openAccess |
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(c) BMJ Publishing Group Ltd and British Society of Gastroenterology, 1998 |
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openAccess |
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5 p. application/pdf |
| dc.publisher.none.fl_str_mv |
BMJ Group |
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BMJ Group |
| dc.source.none.fl_str_mv |
Articles publicats en revistes (Medicina) reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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Recercat. Dipósit de la Recerca de Catalunya |
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Recercat. Dipósit de la Recerca de Catalunya |
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1869410955513823232 |
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15,812429 |