Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples

Sharp-wave ripples represent a prominent synchronous activity pattern in the mammalian hippocampus during sleep and immobility. GABAergic interneuronal types are silenced or fire during these events, but the mechanism of pyramidal cell (PC) participation remains elusive. We found opposite membrane p...

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Autores: Valero, Manuel, Cid, Elena, Averkin, Robert G, Aguilar, Juan, Viney, Tim J, Gómez-Domínguez, Daniel, Bellistri, Elisa, Menéndez de la Prida, Liset, Sánchez-Aguilera López, Alberto
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/95138
Acceso en línea:https://hdl.handle.net/20.500.14352/95138
Access Level:acceso abierto
Palabra clave:611.81
Neurociencias (Medicina)
2490 Neurociencias
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oai_identifier_str oai:docta.ucm.es:20.500.14352/95138
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spelling Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripplesValero, ManuelCid, ElenaAverkin, Robert GAguilar, JuanViney, Tim JGómez-Domínguez, DanielBellistri, ElisaMenéndez de la Prida, LisetSánchez-Aguilera López, Alberto611.81Neurociencias (Medicina)2490 NeurocienciasSharp-wave ripples represent a prominent synchronous activity pattern in the mammalian hippocampus during sleep and immobility. GABAergic interneuronal types are silenced or fire during these events, but the mechanism of pyramidal cell (PC) participation remains elusive. We found opposite membrane polarization of deep (closer to stratum oriens) and superficial (closer to stratum radiatum) rat CA1 PCs during sharp-wave ripples. Using sharp and multi-site recordings in combination with neurochemical profiling, we observed a predominant inhibitory drive of deep calbindin (CB)-immunonegative PCs that contrasts with a prominent depolarization of superficial CB-immunopositive PCs. Biased contribution of perisomatic GABAergic inputs, together with suppression of CA2 PCs, may explain the selection of CA1 PCs during sharp-wave ripples. A deep-superficial gradient interacted with behavioral and spatial effects to determine cell participation during sleep and awake sharp-wave ripples in freely moving rats. Thus, the firing dynamics of hippocampal PCs are exquisitely controlled at subcellular and microcircuit levels in a cell type-selective manner.Springer natureUniversidad Complutense de Madrid20152015-09-0120152015-09-01journal articlehttp://purl.org/coar/resource_type/c_6501CVoRhttp://purl.org/coar/version/c_e19f295774971610info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/95138reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/951382026-06-02T12:44:21Z
dc.title.none.fl_str_mv Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples
title Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples
spellingShingle Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples
Valero, Manuel
611.81
Neurociencias (Medicina)
2490 Neurociencias
title_short Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples
title_full Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples
title_fullStr Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples
title_full_unstemmed Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples
title_sort Determinants of different deep and superficial CA1 pyramidal cell dynamics during sharp-wave ripples
dc.creator.none.fl_str_mv Valero, Manuel
Cid, Elena
Averkin, Robert G
Aguilar, Juan
Viney, Tim J
Gómez-Domínguez, Daniel
Bellistri, Elisa
Menéndez de la Prida, Liset
Sánchez-Aguilera López, Alberto
author Valero, Manuel
author_facet Valero, Manuel
Cid, Elena
Averkin, Robert G
Aguilar, Juan
Viney, Tim J
Gómez-Domínguez, Daniel
Bellistri, Elisa
Menéndez de la Prida, Liset
Sánchez-Aguilera López, Alberto
author_role author
author2 Cid, Elena
Averkin, Robert G
Aguilar, Juan
Viney, Tim J
Gómez-Domínguez, Daniel
Bellistri, Elisa
Menéndez de la Prida, Liset
Sánchez-Aguilera López, Alberto
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 611.81
Neurociencias (Medicina)
2490 Neurociencias
topic 611.81
Neurociencias (Medicina)
2490 Neurociencias
description Sharp-wave ripples represent a prominent synchronous activity pattern in the mammalian hippocampus during sleep and immobility. GABAergic interneuronal types are silenced or fire during these events, but the mechanism of pyramidal cell (PC) participation remains elusive. We found opposite membrane polarization of deep (closer to stratum oriens) and superficial (closer to stratum radiatum) rat CA1 PCs during sharp-wave ripples. Using sharp and multi-site recordings in combination with neurochemical profiling, we observed a predominant inhibitory drive of deep calbindin (CB)-immunonegative PCs that contrasts with a prominent depolarization of superficial CB-immunopositive PCs. Biased contribution of perisomatic GABAergic inputs, together with suppression of CA2 PCs, may explain the selection of CA1 PCs during sharp-wave ripples. A deep-superficial gradient interacted with behavioral and spatial effects to determine cell participation during sleep and awake sharp-wave ripples in freely moving rats. Thus, the firing dynamics of hippocampal PCs are exquisitely controlled at subcellular and microcircuit levels in a cell type-selective manner.
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-09-01
2015
2015-09-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
CVoR
http://purl.org/coar/version/c_e19f295774971610
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/95138
url https://hdl.handle.net/20.500.14352/95138
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer nature
publisher.none.fl_str_mv Springer nature
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410948945543168
score 15.300719

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