Cerebrospinal fluid space alterations in melancholic depression

Melancholic depression is a biologically homogeneous clinical entity in which structural brain alterations have been described. Interestingly, reports of structural alterations in melancholia include volume increases in Cerebro-Spinal Fluid (CSF) spaces. However, there are no previous reports of CSF...

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Detalhes bibliográficos
Autores: Via Virgili, Esther, Cardoner, N. (Narcís), Pujol Nuez, Jesús, Martínez Zalacaín, Ignacio, Hernández Ribas, Rosa, Urretavizcaya Sarachaga, Mikel, López-Solà, Marina, Deus Yela, Juan, Menchón Magriñá, José Manuel, Soriano Mas, Carles
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2012
País:España
Recursos:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/101460
Acesso em linha:https://hdl.handle.net/2445/101460
Access Level:acceso abierto
Palavra-chave:Depressió psíquica
Líquid cefalorraquidi
Cervell
Malenconia
Marcadors bioquímics
Mental depression
Cerebrospinal fluid
Brain
Melancholy
Biochemical markers
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repository_id_str
spelling Cerebrospinal fluid space alterations in melancholic depressionVia Virgili, EstherCardoner, N. (Narcís)Pujol Nuez, JesúsMartínez Zalacaín, IgnacioHernández Ribas, RosaUrretavizcaya Sarachaga, MikelLópez-Solà, MarinaDeus Yela, JuanMenchón Magriñá, José ManuelSoriano Mas, CarlesDepressió psíquicaLíquid cefalorraquidiCervellMalenconiaMarcadors bioquímicsMental depressionCerebrospinal fluidBrainMelancholyBiochemical markersMelancholic depression is a biologically homogeneous clinical entity in which structural brain alterations have been described. Interestingly, reports of structural alterations in melancholia include volume increases in Cerebro-Spinal Fluid (CSF) spaces. However, there are no previous reports of CSF volume alterations using automated whole-brain voxel-wise approaches, as tissue classification algorithms have been traditionally regarded as less reliable for CSF segmentation. Here we aimed to assess CSF volumetric alterations in melancholic depression and their clinical correlates by means of a novel segmentation algorithm ('new segment', as implemented in the software Statistical Parametric Mapping-SPM8), incorporating specific features that may improve CSF segmentation. A three-dimensional Magnetic Resonance Image (MRI) was obtained from seventy patients with melancholic depression and forty healthy control subjects. Although imaging data were pre-processed with the 'new segment' algorithm, in order to obtain a comparison with previous segmentation approaches, tissue segmentation was also performed with the 'unified segmentation' approach. Melancholic patients showed a CSF volume increase in the region of the left Sylvian fissure, and a CSF volume decrease in the subarachnoid spaces surrounding medial and lateral parietal cortices. Furthermore, CSF increases in the left Sylvian fissure were negatively correlated with the reduction percentage of depressive symptoms at discharge. None of these results were replicated with the 'unified segmentation' approach. By contrast, between-group differences in the left Sylvian fissure were replicated with a non-automated quantification of the CSF content of this region. Left Sylvian fissure alterations reported here are in agreement with previous findings from non-automated CSF assessments, and also with other reports of gray and white matter insular alterations in depressive samples using automated approaches. The reliable characterization of CSF alterations may help in the comprehensive characterization of brain structural abnormalities in psychiatric samples and in the development of etiopathogenic hypotheses relating to the disorders.Public Library of Science (PLoS)2012info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/101460Articles publicats en revistes (Ciències Clíniques)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0038299PLoS One, 2012, vol. 7, num. 6, p. e38299http://dx.doi.org/10.1371/journal.pone.0038299cc-by (c) Via, Esther et al., 2012http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/1014602026-05-27T06:46:51Z
dc.title.none.fl_str_mv Cerebrospinal fluid space alterations in melancholic depression
title Cerebrospinal fluid space alterations in melancholic depression
spellingShingle Cerebrospinal fluid space alterations in melancholic depression
Via Virgili, Esther
Depressió psíquica
Líquid cefalorraquidi
Cervell
Malenconia
Marcadors bioquímics
Mental depression
Cerebrospinal fluid
Brain
Melancholy
Biochemical markers
title_short Cerebrospinal fluid space alterations in melancholic depression
title_full Cerebrospinal fluid space alterations in melancholic depression
title_fullStr Cerebrospinal fluid space alterations in melancholic depression
title_full_unstemmed Cerebrospinal fluid space alterations in melancholic depression
title_sort Cerebrospinal fluid space alterations in melancholic depression
dc.creator.none.fl_str_mv Via Virgili, Esther
Cardoner, N. (Narcís)
Pujol Nuez, Jesús
Martínez Zalacaín, Ignacio
Hernández Ribas, Rosa
Urretavizcaya Sarachaga, Mikel
López-Solà, Marina
Deus Yela, Juan
Menchón Magriñá, José Manuel
Soriano Mas, Carles
author Via Virgili, Esther
author_facet Via Virgili, Esther
Cardoner, N. (Narcís)
Pujol Nuez, Jesús
Martínez Zalacaín, Ignacio
Hernández Ribas, Rosa
Urretavizcaya Sarachaga, Mikel
López-Solà, Marina
Deus Yela, Juan
Menchón Magriñá, José Manuel
Soriano Mas, Carles
author_role author
author2 Cardoner, N. (Narcís)
Pujol Nuez, Jesús
Martínez Zalacaín, Ignacio
Hernández Ribas, Rosa
Urretavizcaya Sarachaga, Mikel
López-Solà, Marina
Deus Yela, Juan
Menchón Magriñá, José Manuel
Soriano Mas, Carles
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Depressió psíquica
Líquid cefalorraquidi
Cervell
Malenconia
Marcadors bioquímics
Mental depression
Cerebrospinal fluid
Brain
Melancholy
Biochemical markers
topic Depressió psíquica
Líquid cefalorraquidi
Cervell
Malenconia
Marcadors bioquímics
Mental depression
Cerebrospinal fluid
Brain
Melancholy
Biochemical markers
description Melancholic depression is a biologically homogeneous clinical entity in which structural brain alterations have been described. Interestingly, reports of structural alterations in melancholia include volume increases in Cerebro-Spinal Fluid (CSF) spaces. However, there are no previous reports of CSF volume alterations using automated whole-brain voxel-wise approaches, as tissue classification algorithms have been traditionally regarded as less reliable for CSF segmentation. Here we aimed to assess CSF volumetric alterations in melancholic depression and their clinical correlates by means of a novel segmentation algorithm ('new segment', as implemented in the software Statistical Parametric Mapping-SPM8), incorporating specific features that may improve CSF segmentation. A three-dimensional Magnetic Resonance Image (MRI) was obtained from seventy patients with melancholic depression and forty healthy control subjects. Although imaging data were pre-processed with the 'new segment' algorithm, in order to obtain a comparison with previous segmentation approaches, tissue segmentation was also performed with the 'unified segmentation' approach. Melancholic patients showed a CSF volume increase in the region of the left Sylvian fissure, and a CSF volume decrease in the subarachnoid spaces surrounding medial and lateral parietal cortices. Furthermore, CSF increases in the left Sylvian fissure were negatively correlated with the reduction percentage of depressive symptoms at discharge. None of these results were replicated with the 'unified segmentation' approach. By contrast, between-group differences in the left Sylvian fissure were replicated with a non-automated quantification of the CSF content of this region. Left Sylvian fissure alterations reported here are in agreement with previous findings from non-automated CSF assessments, and also with other reports of gray and white matter insular alterations in depressive samples using automated approaches. The reliable characterization of CSF alterations may help in the comprehensive characterization of brain structural abnormalities in psychiatric samples and in the development of etiopathogenic hypotheses relating to the disorders.
publishDate 2012
dc.date.none.fl_str_mv 2012
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/101460
url https://hdl.handle.net/2445/101460
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: http://dx.doi.org/10.1371/journal.pone.0038299
PLoS One, 2012, vol. 7, num. 6, p. e38299
http://dx.doi.org/10.1371/journal.pone.0038299
dc.rights.none.fl_str_mv cc-by (c) Via, Esther et al., 2012
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Via, Esther et al., 2012
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science (PLoS)
publisher.none.fl_str_mv Public Library of Science (PLoS)
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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