Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agents

Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for non-invasive clinical diagnosis due to its high degree of soft-tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times (T1, spin-lattice relax...

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Authors: Estelrich i Latràs, Joan, Sánchez Martín, Ma. Jesús, Busquets i Viñas, Ma. Antonia
Format: article
Status:Published version
Publication Date:2015
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/149502
Online Access:https://hdl.handle.net/2445/149502
Access Level:Open access
Keyword:Nanopartícules
Òxid de ferro
Imatges per ressonància magnètica
Nanoparticles
Ferric oxide
Magnetic resonance imaging
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spelling Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agentsEstelrich i Latràs, JoanSánchez Martín, Ma. JesúsBusquets i Viñas, Ma. AntoniaNanopartículesÒxid de ferroImatges per ressonància magnèticaNanoparticlesFerric oxideMagnetic resonance imagingMagnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for non-invasive clinical diagnosis due to its high degree of soft-tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times (T1, spin-lattice relaxation and T2, spin-spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior the scanning. Shortening T1 and T2 increases the corresponding relaxation rates, 1/T1 and 1/T2, producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T2-weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T1-weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can furthermore incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.Dove Medical Press2020202020152020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/149502Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.2147/IJN.S76501International Journal of Nanomedicine, 2015, vol. 10, num. 1, p. 1727-1741https://doi.org/10.2147/IJN.S76501cc-by-nc (c) Estelrich i Latràs, Joan et al., 2015http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1495022026-05-29T05:05:01Z
dc.title.none.fl_str_mv Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agents
title Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agents
spellingShingle Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agents
Estelrich i Latràs, Joan
Nanopartícules
Òxid de ferro
Imatges per ressonància magnètica
Nanoparticles
Ferric oxide
Magnetic resonance imaging
title_short Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agents
title_full Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agents
title_fullStr Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agents
title_full_unstemmed Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agents
title_sort Nanoparticles in Magnetic Resonance Imaging: from simple to dual contrast agents
dc.creator.none.fl_str_mv Estelrich i Latràs, Joan
Sánchez Martín, Ma. Jesús
Busquets i Viñas, Ma. Antonia
author Estelrich i Latràs, Joan
author_facet Estelrich i Latràs, Joan
Sánchez Martín, Ma. Jesús
Busquets i Viñas, Ma. Antonia
author_role author
author2 Sánchez Martín, Ma. Jesús
Busquets i Viñas, Ma. Antonia
author2_role author
author
dc.subject.none.fl_str_mv Nanopartícules
Òxid de ferro
Imatges per ressonància magnètica
Nanoparticles
Ferric oxide
Magnetic resonance imaging
topic Nanopartícules
Òxid de ferro
Imatges per ressonància magnètica
Nanoparticles
Ferric oxide
Magnetic resonance imaging
description Magnetic resonance imaging (MRI) has become one of the most widely used and powerful tools for non-invasive clinical diagnosis due to its high degree of soft-tissue contrast, spatial resolution, and depth of penetration. MRI signal intensity is related to the relaxation times (T1, spin-lattice relaxation and T2, spin-spin relaxation) of in vivo water protons. To increase contrast, various inorganic nanoparticles and complexes (the so-called contrast agents) are administered prior the scanning. Shortening T1 and T2 increases the corresponding relaxation rates, 1/T1 and 1/T2, producing hyperintense and hypointense signals respectively in shorter times. Moreover, the signal-to-noise ratio can be improved with the acquisition of a large number of measurements. The contrast agents used are generally based on either iron oxide nanoparticles or ferrites, providing negative contrast in T2-weighted images; or complexes of lanthanide metals (mostly containing gadolinium ions), providing positive contrast in T1-weighted images. Recently, lanthanide complexes have been immobilized in nanostructured materials in order to develop a new class of contrast agents with functions including blood-pool and organ (or tumor) targeting. Meanwhile, to overcome the limitations of individual imaging modalities, multimodal imaging techniques have been developed. An important challenge is to design all-in-one contrast agents that can be detected by multimodal techniques. Magnetoliposomes are efficient multimodal contrast agents. They can simultaneously bear both kinds of contrast and can furthermore incorporate targeting ligands and chains of polyethylene glycol to enhance the accumulation of nanoparticles at the site of interest and the bioavailability, respectively. Here, we review the most important characteristics of the nanoparticles or complexes used as MRI contrast agents.
publishDate 2015
dc.date.none.fl_str_mv 2015
2020
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/149502
url https://hdl.handle.net/2445/149502
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.2147/IJN.S76501
International Journal of Nanomedicine, 2015, vol. 10, num. 1, p. 1727-1741
https://doi.org/10.2147/IJN.S76501
dc.rights.none.fl_str_mv cc-by-nc (c) Estelrich i Latràs, Joan et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Estelrich i Latràs, Joan et al., 2015
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv Dove Medical Press
publisher.none.fl_str_mv Dove Medical Press
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410944695664640
score 15,812429

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