Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic
Background: Lung cancer (LC) is the leading cause of cancer-related death. Early detection strategies include LC screening (LCS) with low-dose computed tomography (LDCT) and incidental pulmonary nodule clinics (IPNCs). This study describes the structure, workflow, and outcomes of an integrated early...
| Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | article |
| Status: | Published version |
| Publication Date: | 2025 |
| Country: | España |
| Institution: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repository: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:10459.1/469556 |
| Online Access: | https://doi.org/10.1016/j.opresp.2025.100527 https://hdl.handle.net/10459.1/469556 http://hdl.handle.net/10459.1/469556 |
| Access Level: | Open access |
| Keyword: | Chronic obstructive pulmonary disease Early-stage lung cancer Emphysema Low-dose computed tomography Lung cancer screening Pulmonary nodule |
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Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule ClinicSánchez Cucó, AnnaSantisteve, SallyVila, AnnaManzano, CarlosZuil, MariaMonge, AidaSanz, ClaraGracia Lavedan, EstherRamírez Seco, NereaSuárez, MarcelaBarril, SilviaEl Arfaoui, WassimBenítez, IvánGatius Calderó, SòniaRombolá, CarlosFernández, LeandrePardina, MarinaEsqué, Maria TeresaGarcia, VirginiaGonzález, José DavidSampedro, Cora AndreaMontesinos, MarioAviles, Juan DiegoRodrigo, AlbertoAbellaneda, JacintoFarré, PereVilo, Lidiade Gonzalo Calvo, DavidYip, RowenaYankelevitz, DavidHenschke, ClaudiaBarbé Illa, FerranGonzález, JessicaChronic obstructive pulmonary diseaseEarly-stage lung cancerEmphysemaLow-dose computed tomographyLung cancer screeningPulmonary noduleBackground: Lung cancer (LC) is the leading cause of cancer-related death. Early detection strategies include LC screening (LCS) with low-dose computed tomography (LDCT) and incidental pulmonary nodule clinics (IPNCs). This study describes the structure, workflow, and outcomes of an integrated early diagnosis strategy combining LCS and IPNCs. Material and methods: We conducted a descriptive analysis of a prospective observational study (May 2023–June 2025) implementing an integrated IPNC-LCS model. All IPNC patients underwent initial LCrisk assessment: highly suspicious lesions were referred to a fast-track diagnostic pathway, low-risk patients to primary care (PC), and high-risk individuals to the LCS program. Additional referrals to the LCS program were received from pulmonology clinics and PC. The LCS program followed the I-ELCAP protocol, including LDCT, lung function testing, 1-antitrypsin deficiency (AATD) screening, and smoking cessation support. Results: The IPNC evaluated 481 individuals: 30 (6.2%) had suspicious lung lesions, with four stage I LC confirmed; 282 (58.6%) were classified as low-risk; and 150 (31.2%) as high risk of whom 97 were enrolled in LCS. The LCS program also received 199 referrals from PC and 122 from pulmonology clinics, totaling 418 participants at baseline (63.2% male; mean age 63.0 ± 6.43 years; 52.9% former smokers; 39.7% with COPD; 67.9% with emphysema). New diagnoses included emphysema (n = 106), COPD (n = 25), and AATD mutations (n = 95). Smoking cessation referral was accepted by 74% of smokers. LC was detected in 17 participants (4.07%), 14 (82.4%) at stage I, all receiving curative-intent treatment. Conclusions: This integrated IPNC–LCS model achieved high early-stage LC detection and enabled curative treatment, while uncovering unrecognized respiratory comorbidities and promoting smoking cessation.Elsevier2025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://doi.org/10.1016/j.opresp.2025.100527https://hdl.handle.net/10459.1/469556http://hdl.handle.net/10459.1/469556reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a https://doi.org/10.1016/j.opresp.2025.100527Open Respiratory Archives, 2025, vol. 8, núm. 1, 100527cc-by-nc-nd, (c) Anna Sánchez Cucó et al., 2025Attribution-NonCommercial-NoDerivatives 4.0 Internationalinfo:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by-nc-nd/4.0/oai:recercat.cat:10459.1/4695562026-05-29T05:05:01Z |
| dc.title.none.fl_str_mv |
Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic |
| title |
Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic |
| spellingShingle |
Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic Sánchez Cucó, Anna Chronic obstructive pulmonary disease Early-stage lung cancer Emphysema Low-dose computed tomography Lung cancer screening Pulmonary nodule |
| title_short |
Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic |
| title_full |
Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic |
| title_fullStr |
Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic |
| title_full_unstemmed |
Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic |
| title_sort |
Innovative Approach to Early Lung Cancer Detection: Integrating a Comprehensive Screening Program and an Incidental Pulmonary Nodule Clinic |
| dc.creator.none.fl_str_mv |
Sánchez Cucó, Anna Santisteve, Sally Vila, Anna Manzano, Carlos Zuil, Maria Monge, Aida Sanz, Clara Gracia Lavedan, Esther Ramírez Seco, Nerea Suárez, Marcela Barril, Silvia El Arfaoui, Wassim Benítez, Iván Gatius Calderó, Sònia Rombolá, Carlos Fernández, Leandre Pardina, Marina Esqué, Maria Teresa Garcia, Virginia González, José David Sampedro, Cora Andrea Montesinos, Mario Aviles, Juan Diego Rodrigo, Alberto Abellaneda, Jacinto Farré, Pere Vilo, Lidia de Gonzalo Calvo, David Yip, Rowena Yankelevitz, David Henschke, Claudia Barbé Illa, Ferran González, Jessica |
| author |
Sánchez Cucó, Anna |
| author_facet |
Sánchez Cucó, Anna Santisteve, Sally Vila, Anna Manzano, Carlos Zuil, Maria Monge, Aida Sanz, Clara Gracia Lavedan, Esther Ramírez Seco, Nerea Suárez, Marcela Barril, Silvia El Arfaoui, Wassim Benítez, Iván Gatius Calderó, Sònia Rombolá, Carlos Fernández, Leandre Pardina, Marina Esqué, Maria Teresa Garcia, Virginia González, José David Sampedro, Cora Andrea Montesinos, Mario Aviles, Juan Diego Rodrigo, Alberto Abellaneda, Jacinto Farré, Pere Vilo, Lidia de Gonzalo Calvo, David Yip, Rowena Yankelevitz, David Henschke, Claudia Barbé Illa, Ferran González, Jessica |
| author_role |
author |
| author2 |
Santisteve, Sally Vila, Anna Manzano, Carlos Zuil, Maria Monge, Aida Sanz, Clara Gracia Lavedan, Esther Ramírez Seco, Nerea Suárez, Marcela Barril, Silvia El Arfaoui, Wassim Benítez, Iván Gatius Calderó, Sònia Rombolá, Carlos Fernández, Leandre Pardina, Marina Esqué, Maria Teresa Garcia, Virginia González, José David Sampedro, Cora Andrea Montesinos, Mario Aviles, Juan Diego Rodrigo, Alberto Abellaneda, Jacinto Farré, Pere Vilo, Lidia de Gonzalo Calvo, David Yip, Rowena Yankelevitz, David Henschke, Claudia Barbé Illa, Ferran González, Jessica |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Chronic obstructive pulmonary disease Early-stage lung cancer Emphysema Low-dose computed tomography Lung cancer screening Pulmonary nodule |
| topic |
Chronic obstructive pulmonary disease Early-stage lung cancer Emphysema Low-dose computed tomography Lung cancer screening Pulmonary nodule |
| description |
Background: Lung cancer (LC) is the leading cause of cancer-related death. Early detection strategies include LC screening (LCS) with low-dose computed tomography (LDCT) and incidental pulmonary nodule clinics (IPNCs). This study describes the structure, workflow, and outcomes of an integrated early diagnosis strategy combining LCS and IPNCs. Material and methods: We conducted a descriptive analysis of a prospective observational study (May 2023–June 2025) implementing an integrated IPNC-LCS model. All IPNC patients underwent initial LCrisk assessment: highly suspicious lesions were referred to a fast-track diagnostic pathway, low-risk patients to primary care (PC), and high-risk individuals to the LCS program. Additional referrals to the LCS program were received from pulmonology clinics and PC. The LCS program followed the I-ELCAP protocol, including LDCT, lung function testing, 1-antitrypsin deficiency (AATD) screening, and smoking cessation support. Results: The IPNC evaluated 481 individuals: 30 (6.2%) had suspicious lung lesions, with four stage I LC confirmed; 282 (58.6%) were classified as low-risk; and 150 (31.2%) as high risk of whom 97 were enrolled in LCS. The LCS program also received 199 referrals from PC and 122 from pulmonology clinics, totaling 418 participants at baseline (63.2% male; mean age 63.0 ± 6.43 years; 52.9% former smokers; 39.7% with COPD; 67.9% with emphysema). New diagnoses included emphysema (n = 106), COPD (n = 25), and AATD mutations (n = 95). Smoking cessation referral was accepted by 74% of smokers. LC was detected in 17 participants (4.07%), 14 (82.4%) at stage I, all receiving curative-intent treatment. Conclusions: This integrated IPNC–LCS model achieved high early-stage LC detection and enabled curative treatment, while uncovering unrecognized respiratory comorbidities and promoting smoking cessation. |
| publishDate |
2025 |
| dc.date.none.fl_str_mv |
2025 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://doi.org/10.1016/j.opresp.2025.100527 https://hdl.handle.net/10459.1/469556 http://hdl.handle.net/10459.1/469556 |
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https://doi.org/10.1016/j.opresp.2025.100527 https://hdl.handle.net/10459.1/469556 http://hdl.handle.net/10459.1/469556 |
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Inglés |
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Inglés |
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Reproducció del document publicat a https://doi.org/10.1016/j.opresp.2025.100527 Open Respiratory Archives, 2025, vol. 8, núm. 1, 100527 |
| dc.rights.none.fl_str_mv |
cc-by-nc-nd, (c) Anna Sánchez Cucó et al., 2025 Attribution-NonCommercial-NoDerivatives 4.0 International info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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cc-by-nc-nd, (c) Anna Sánchez Cucó et al., 2025 Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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openAccess |
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Elsevier |
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Elsevier |
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reponame:Recercat. Dipósit de la Recerca de Catalunya instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
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