In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice

Promising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of the nanoparticle performance in the cellular environment. This constitutes a huge research challenge due to difficulties for achieving a remote control within the human body. Here we report on the significa...

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Detalles Bibliográficos
Autores: Simeonidis, Konstantinos, Puerto Morales, M., Marciello, Marzia, Angelakeris, Makis, De la Presa, Patricia, Lazaro-Carrillo, Ana, Tabero, Ana, Villanueva Oroquieta, Ángeles, Chubykalo-Fesenko, Oksana, Serantes, David
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/679299
Acceso en línea:http://hdl.handle.net/10486/679299
https://dx.doi.org/10.1038/srep38382
Access Level:acceso abierto
Palabra clave:Nanomedicine
Magnetic hyperthermia
Nanorods
HeLa cells
Biología y Biomedicina / Biología
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spelling In-situ particles reorientation during magnetic hyperthermia application: Shape matters twiceSimeonidis, KonstantinosPuerto Morales, M.Marciello, MarziaAngelakeris, MakisDe la Presa, PatriciaLazaro-Carrillo, AnaTabero, AnaVillanueva Oroquieta, ÁngelesChubykalo-Fesenko, OksanaSerantes, DavidNanomedicineMagnetic hyperthermiaNanorodsHeLa cellsBiología y Biomedicina / BiologíaPromising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of the nanoparticle performance in the cellular environment. This constitutes a huge research challenge due to difficulties for achieving a remote control within the human body. Here we report on the significant double role of the shape of ellipsoidal magnetic nanoparticles (nanorods) subjected to an external AC magnetic field: first, the heat release is increased due to the additional shape anisotropy; second, the rods dynamically reorientate in the orthogonal direction to the AC field direction. Importantly, the heating performance and the directional orientation occur in synergy and can be easily controlled by changing the AC field treatment duration, thus opening the pathway to combined hyperthermic/ mechanical nanoactuators for biomedicine. Preliminary studies demonstrate the high accumulation of nanorods into HeLa cells whereas viability analysis supports their low toxicity and the absence of apoptotic or necrotic cell death after 24 or 48 h of incubationThis work was partially supported by the EC FP-7 grant “NanoMag” (grant agreement no. 604448), the Spanish Ministry of Economy and Competitiveness (MAT2013-47078-C2-2-P, MAT2014-52069-R, MAT2013-47395-C4-3-R, MAT2015- 67557-C2-1-P-MICINN, CONSOLIDER CSD2007-00041, CTQ2013-48767-C3-3-R), and Gobierno de la Comunidad de Madrid (NANOFRONTMAG, S2013/MIT-2850). D.S. acknowledges financial support from Xunta de Galicia (I2C Postdoctoral Plan). A.T. thanks UAM for a predoctoral contractNature Publishing GroupDepartamento de BiologíaFacultad de Ciencias20162016-12-06research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/679299https://dx.doi.org/10.1038/srep38382reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6792992026-06-23T12:46:27Z
dc.title.none.fl_str_mv In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
spellingShingle In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
Simeonidis, Konstantinos
Nanomedicine
Magnetic hyperthermia
Nanorods
HeLa cells
Biología y Biomedicina / Biología
title_short In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title_full In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title_fullStr In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title_full_unstemmed In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
title_sort In-situ particles reorientation during magnetic hyperthermia application: Shape matters twice
dc.creator.none.fl_str_mv Simeonidis, Konstantinos
Puerto Morales, M.
Marciello, Marzia
Angelakeris, Makis
De la Presa, Patricia
Lazaro-Carrillo, Ana
Tabero, Ana
Villanueva Oroquieta, Ángeles
Chubykalo-Fesenko, Oksana
Serantes, David
author Simeonidis, Konstantinos
author_facet Simeonidis, Konstantinos
Puerto Morales, M.
Marciello, Marzia
Angelakeris, Makis
De la Presa, Patricia
Lazaro-Carrillo, Ana
Tabero, Ana
Villanueva Oroquieta, Ángeles
Chubykalo-Fesenko, Oksana
Serantes, David
author_role author
author2 Puerto Morales, M.
Marciello, Marzia
Angelakeris, Makis
De la Presa, Patricia
Lazaro-Carrillo, Ana
Tabero, Ana
Villanueva Oroquieta, Ángeles
Chubykalo-Fesenko, Oksana
Serantes, David
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Biología
Facultad de Ciencias
dc.subject.none.fl_str_mv Nanomedicine
Magnetic hyperthermia
Nanorods
HeLa cells
Biología y Biomedicina / Biología
topic Nanomedicine
Magnetic hyperthermia
Nanorods
HeLa cells
Biología y Biomedicina / Biología
description Promising advances in nanomedicine such as magnetic hyperthermia rely on a precise control of the nanoparticle performance in the cellular environment. This constitutes a huge research challenge due to difficulties for achieving a remote control within the human body. Here we report on the significant double role of the shape of ellipsoidal magnetic nanoparticles (nanorods) subjected to an external AC magnetic field: first, the heat release is increased due to the additional shape anisotropy; second, the rods dynamically reorientate in the orthogonal direction to the AC field direction. Importantly, the heating performance and the directional orientation occur in synergy and can be easily controlled by changing the AC field treatment duration, thus opening the pathway to combined hyperthermic/ mechanical nanoactuators for biomedicine. Preliminary studies demonstrate the high accumulation of nanorods into HeLa cells whereas viability analysis supports their low toxicity and the absence of apoptotic or necrotic cell death after 24 or 48 h of incubation
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-12-06
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/679299
https://dx.doi.org/10.1038/srep38382
url http://hdl.handle.net/10486/679299
https://dx.doi.org/10.1038/srep38382
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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