Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy

Data de publicació electrònica: 13-01-2022

Bibliographic Details
Authors: Echeverría, Luis Eduardo, Rojas, Lyda Z., Rueda-Ochoa, Oscar L., Gómez-Ochoa, Sergio Alejandro, Mayer, Miguel Ángel, 1960-, Becerra-Motta, Lisbeth Paola, Luengas, Carlos, Chaves, Angel M., Rodríguez, Jaime A., Morillo, Carlos A.
Format: article
Status:Published version
Publication Date:2022
Country:España
Institution:Universitat Pompeu Fabra
Repository:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/54147
Online Access:http://hdl.handle.net/10230/54147
http://dx.doi.org/10.1007/s10554-021-02508-5
Access Level:Open access
Keyword:Chagas disease
Chronic Chagas cardiomyopathy
Echocardiography
Speckle tracking
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spelling Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathyEcheverría, Luis EduardoRojas, Lyda Z.Rueda-Ochoa, Oscar L.Gómez-Ochoa, Sergio AlejandroMayer, Miguel Ángel, 1960-Becerra-Motta, Lisbeth PaolaLuengas, CarlosChaves, Angel M.Rodríguez, Jaime A.Morillo, Carlos A.Chagas diseaseChronic Chagas cardiomyopathyEchocardiographySpeckle trackingData de publicació electrònica: 13-01-2022To analyze the prognostic value of left ventricular global longitudinal strain (LV-GLS) and other echocardiographic parameters to predict adverse outcomes in chronic Chagas cardiomyopathy (CCM). Prospective cohort study conducted in 177 consecutive patients with different CCM stages. Transthoracic echocardiography measurements were obtained following the American Society of Echocardiography recommendations. By speckle-tracking echocardiography, LV-GLS was obtained from the apical three-chamber, apical two-chamber, and apical four-chamber views. The primary composite outcome (CO) was all-cause mortality, cardiac transplantation, and a left ventricular assist device implantation. After a median follow-up of 42.3 months (Q1 = 38.6; Q3 = 52.1), the CO incidence was 22.6% (95% CI 16.7-29.5%, n = 40). The median LV-GLS value was - 13.6% (Q1 = - 18.6%; Q3 = - 8.5%). LVEF, LV-GLS, and E/e' ratio with cut-off points of 40%, - 9, and 8.1, respectively, were the best independent CO predictors. We combined these three echocardiographic markers and evaluated the risk of CO according to the number of altered parameters, finding a significant increase in the risk across the groups. While in the group of patients in which all these three parameters were normal, only 3.2% had the CO; those with all three abnormal parameters had an incidence of 60%. We observed a potential incremental prognostic value of LV-GLS in the multivariate model of LVEF and E/e' ratio, as the AUC increased slightly from 0.76 to 0.79, nevertheless, this difference was not statistically significant (p = 0.066). LV-GLS is an important predictor of adverse cardiovascular events in CCM, providing a potential incremental prognostic value to LVEF and E/e' ratio when analyzed using optimal cut-off points, highlighting the potential utility of multimodal echocardiographic tools for predicting adverse outcomes in CCM.Springer202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/54147http://dx.doi.org/10.1007/s10554-021-02508-5reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésInt J Cardiovasc Imaging. 2022 Jan 13© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/541472026-06-12T07:21:37Z
dc.title.none.fl_str_mv Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy
title Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy
spellingShingle Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy
Echeverría, Luis Eduardo
Chagas disease
Chronic Chagas cardiomyopathy
Echocardiography
Speckle tracking
title_short Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy
title_full Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy
title_fullStr Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy
title_full_unstemmed Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy
title_sort Longitudinal strain by speckle tracking and echocardiographic parameters as predictors of adverse cardiovascular outcomes in chronic Chagas cardiomyopathy
dc.creator.none.fl_str_mv Echeverría, Luis Eduardo
Rojas, Lyda Z.
Rueda-Ochoa, Oscar L.
Gómez-Ochoa, Sergio Alejandro
Mayer, Miguel Ángel, 1960-
Becerra-Motta, Lisbeth Paola
Luengas, Carlos
Chaves, Angel M.
Rodríguez, Jaime A.
Morillo, Carlos A.
author Echeverría, Luis Eduardo
author_facet Echeverría, Luis Eduardo
Rojas, Lyda Z.
Rueda-Ochoa, Oscar L.
Gómez-Ochoa, Sergio Alejandro
Mayer, Miguel Ángel, 1960-
Becerra-Motta, Lisbeth Paola
Luengas, Carlos
Chaves, Angel M.
Rodríguez, Jaime A.
Morillo, Carlos A.
author_role author
author2 Rojas, Lyda Z.
Rueda-Ochoa, Oscar L.
Gómez-Ochoa, Sergio Alejandro
Mayer, Miguel Ángel, 1960-
Becerra-Motta, Lisbeth Paola
Luengas, Carlos
Chaves, Angel M.
Rodríguez, Jaime A.
Morillo, Carlos A.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Chagas disease
Chronic Chagas cardiomyopathy
Echocardiography
Speckle tracking
topic Chagas disease
Chronic Chagas cardiomyopathy
Echocardiography
Speckle tracking
description Data de publicació electrònica: 13-01-2022
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/54147
http://dx.doi.org/10.1007/s10554-021-02508-5
url http://hdl.handle.net/10230/54147
http://dx.doi.org/10.1007/s10554-021-02508-5
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Int J Cardiovasc Imaging. 2022 Jan 13
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410936218976256
score 15,812429

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