Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update

Aldehyde dehydrogenase 2 (ALDH2) is best known for its critical detoxifying role in liver alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, ne...

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Authors: Panisello Roselló, Arnau, Lopez, Alexandre, Folch i Puy, Emma, Carbonell i Camós, Teresa, Rolo, Anabela P., Palmeira, Carlos M., Adam, R. (René), Net Abraham, Marc, Roselló Catafau, Juan
Format: article
Status:Published version
Publication Date:2018
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/124580
Online Access:https://hdl.handle.net/2445/124580
Access Level:Open access
Keyword:Isquèmia
Proteïnes
Ischemia
Proteins
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spelling Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An updatePanisello Roselló, ArnauLopez, AlexandreFolch i Puy, EmmaCarbonell i Camós, TeresaRolo, Anabela P.Palmeira, Carlos M.Adam, R. (René)Net Abraham, MarcRoselló Catafau, JuanIsquèmiaProteïnesIschemiaProteinsAldehyde dehydrogenase 2 (ALDH2) is best known for its critical detoxifying role in liver alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, neurodegenerative diseases and aging. A growing body of research has shown that ALDH2 provides important protection against oxidative stress and the subsequent loading of toxic aldehydes such as 4-hydroxy-2-nonenal and adducts that occur in human diseases, including ischemia reperfusion injury (IRI). There is increasing evidence of its role in IRI pathophysiology in organs such as heart, brain, small intestine and kidney; however, surprisingly few studies have been carried out in the liver, where ALDH2 is found in abundance. This study reviews the role of ALDH2 in modulating the pathways involved in the pathophysiology of IRI associated with oxidative stress, autophagy and apoptosis. Special emphasis is placed on the role of ALDH2 in different organs, on therapeutic "preconditioning" strategies, and on the use of ALDH2 agonists such as Alda-1, which may become a useful therapeutic tool for preventing the deleterious effects of IRI in organ transplantation.Baishideng Publishing Group2018201820182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion15 p.application/pdfhttps://hdl.handle.net/2445/124580Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3748/wjg.v24.i27.2984World Journal of Gastroenterology, 2018, vol. 24, num. 27, p. 2984-2994https://doi.org/10.3748/wjg.v24.i27.2984info:eu-repo/grantAgreement/EC/H2020/722619 cc-by-nc (c) Panisello-Roselló, A. et al., 2018http://creativecommons.org/licenses/by-nc/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1245802026-05-29T05:05:01Z
dc.title.none.fl_str_mv Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
spellingShingle Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
Panisello Roselló, Arnau
Isquèmia
Proteïnes
Ischemia
Proteins
title_short Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title_full Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title_fullStr Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title_full_unstemmed Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
title_sort Role of aldehyde dehydrogenase 2 in ischemia reperfusion injury: An update
dc.creator.none.fl_str_mv Panisello Roselló, Arnau
Lopez, Alexandre
Folch i Puy, Emma
Carbonell i Camós, Teresa
Rolo, Anabela P.
Palmeira, Carlos M.
Adam, R. (René)
Net Abraham, Marc
Roselló Catafau, Juan
author Panisello Roselló, Arnau
author_facet Panisello Roselló, Arnau
Lopez, Alexandre
Folch i Puy, Emma
Carbonell i Camós, Teresa
Rolo, Anabela P.
Palmeira, Carlos M.
Adam, R. (René)
Net Abraham, Marc
Roselló Catafau, Juan
author_role author
author2 Lopez, Alexandre
Folch i Puy, Emma
Carbonell i Camós, Teresa
Rolo, Anabela P.
Palmeira, Carlos M.
Adam, R. (René)
Net Abraham, Marc
Roselló Catafau, Juan
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Isquèmia
Proteïnes
Ischemia
Proteins
topic Isquèmia
Proteïnes
Ischemia
Proteins
description Aldehyde dehydrogenase 2 (ALDH2) is best known for its critical detoxifying role in liver alcohol metabolism. However, ALDH2 dysfunction is also involved in a wide range of human pathophysiological situations and is associated with complications such as cardiovascular diseases, diabetes mellitus, neurodegenerative diseases and aging. A growing body of research has shown that ALDH2 provides important protection against oxidative stress and the subsequent loading of toxic aldehydes such as 4-hydroxy-2-nonenal and adducts that occur in human diseases, including ischemia reperfusion injury (IRI). There is increasing evidence of its role in IRI pathophysiology in organs such as heart, brain, small intestine and kidney; however, surprisingly few studies have been carried out in the liver, where ALDH2 is found in abundance. This study reviews the role of ALDH2 in modulating the pathways involved in the pathophysiology of IRI associated with oxidative stress, autophagy and apoptosis. Special emphasis is placed on the role of ALDH2 in different organs, on therapeutic "preconditioning" strategies, and on the use of ALDH2 agonists such as Alda-1, which may become a useful therapeutic tool for preventing the deleterious effects of IRI in organ transplantation.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/124580
url https://hdl.handle.net/2445/124580
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3748/wjg.v24.i27.2984
World Journal of Gastroenterology, 2018, vol. 24, num. 27, p. 2984-2994
https://doi.org/10.3748/wjg.v24.i27.2984
info:eu-repo/grantAgreement/EC/H2020/722619
dc.rights.none.fl_str_mv cc-by-nc (c) Panisello-Roselló, A. et al., 2018
http://creativecommons.org/licenses/by-nc/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc (c) Panisello-Roselló, A. et al., 2018
http://creativecommons.org/licenses/by-nc/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 15 p.
application/pdf
dc.publisher.none.fl_str_mv Baishideng Publishing Group
publisher.none.fl_str_mv Baishideng Publishing Group
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.198674

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