The pattern of histone H3 epigenetic posttranslational modifications is regulated by the VRK1 chromatin kinase

[Background]: Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in different nuclear functions. These histone epigenetic modifications need to be coord...

ver descrição completa

Detalhes bibliográficos
Autores: Monte-Serrano, Eva, Morejón-García, Patricia, Campillo-Marcos, Ignacio, Campos Díaz, Aurora, Navarro Carrasco, Elena, Lazo, Pedro A.
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/348146
Acesso em linha:http://hdl.handle.net/10261/348146
Access Level:acceso abierto
Palavra-chave:Histone H3
Acetylation
Methylation
Kinase
Chromatin
VRK-IN-1
Descrição
Resumo:[Background]: Dynamic chromatin remodeling is associated with changes in the epigenetic pattern of histone acetylations and methylations required for processes based on dynamic chromatin remodeling and implicated in different nuclear functions. These histone epigenetic modifications need to be coordinated, a role that may be mediated by chromatin kinases such as VRK1, which phosphorylates histones H3 and H2A.