COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.

Since the emergence of SARS-CoV-2 in late 2019, the global mortality attributable to COVID-19 has reached 6,972,152 deaths according to the World Health Organization (WHO). The association between coinfection with Clostridioides difficile (CDI) and SARS-CoV-2 has limited data in the literature. This...

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Autores: Stoian M, Andone A, Boeriu A, Bândila SR, Dobru D, Laszlo S?, Corau D, Arbana?i EM, Russu E, Stoian A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p17041
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/17041
Access Level:acceso abierto
Palabra clave:Clostridioides difficile
SARS-CoV-2
antibiotic therapy
corticosteroid therapy
intensive care unit
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spelling COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.Stoian MAndone ABoeriu ABândila SRDobru DLaszlo S?Corau DArbana?i EMRussu EStoian AClostridioides difficileSARS-CoV-2antibiotic therapycorticosteroid therapyintensive care unitSince the emergence of SARS-CoV-2 in late 2019, the global mortality attributable to COVID-19 has reached 6,972,152 deaths according to the World Health Organization (WHO). The association between coinfection with Clostridioides difficile (CDI) and SARS-CoV-2 has limited data in the literature. This retrospective study, conducted at Mure? County Clinical Hospital in Romania, involved 3002 ICU patients. Following stringent inclusion and exclusion criteria, 63 patients were enrolled, with a division into two subgroups-SARS-CoV-2 + CDI patients and CDI patients. Throughout their hospitalization, the patients were closely monitored. Analysis revealed no significant correlation between comorbidities and invasive mechanical ventilation (IMV) or non-invasive mechanical ventilation (NIMV). However, statistically significant associations were noted between renal and hepatic comorbidties (p = 0.009), death and CDI-SARS-CoV-2 coinfection (p = 0.09), flourochinolone treatment and CDI-SARS-CoV-2 infection (p = 0.03), and an association between diabetes mellitus and SARS-CoV-2-CDI infection (p = 0.04), as well as the need for invasive mechanical ventilation (p = 0.04). The patients with CDI treatment were significantly younger and received immuno-modulator or corticotherapy treatment, which was a risk factor for opportunistic agents. Antibiotic and PPI (proton pump inhibitor) treatment were significant risk factors for CDI coinfection, as well as for death, with PPI treatment in combination with antibiotic treatment being a more significant risk factor.MDPI2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/17041Antibiotics-BaselISSN: 20796382reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p170412026-06-11T12:45:17Z
dc.title.none.fl_str_mv COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.
title COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.
spellingShingle COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.
Stoian M
Clostridioides difficile
SARS-CoV-2
antibiotic therapy
corticosteroid therapy
intensive care unit
title_short COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.
title_full COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.
title_fullStr COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.
title_full_unstemmed COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.
title_sort COVID-19 and Clostridioides difficile Coinfection Analysis in the Intensive Care Unit.
dc.creator.none.fl_str_mv Stoian M
Andone A
Boeriu A
Bândila SR
Dobru D
Laszlo S?
Corau D
Arbana?i EM
Russu E
Stoian A
author Stoian M
author_facet Stoian M
Andone A
Boeriu A
Bândila SR
Dobru D
Laszlo S?
Corau D
Arbana?i EM
Russu E
Stoian A
author_role author
author2 Andone A
Boeriu A
Bândila SR
Dobru D
Laszlo S?
Corau D
Arbana?i EM
Russu E
Stoian A
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Clostridioides difficile
SARS-CoV-2
antibiotic therapy
corticosteroid therapy
intensive care unit
topic Clostridioides difficile
SARS-CoV-2
antibiotic therapy
corticosteroid therapy
intensive care unit
description Since the emergence of SARS-CoV-2 in late 2019, the global mortality attributable to COVID-19 has reached 6,972,152 deaths according to the World Health Organization (WHO). The association between coinfection with Clostridioides difficile (CDI) and SARS-CoV-2 has limited data in the literature. This retrospective study, conducted at Mure? County Clinical Hospital in Romania, involved 3002 ICU patients. Following stringent inclusion and exclusion criteria, 63 patients were enrolled, with a division into two subgroups-SARS-CoV-2 + CDI patients and CDI patients. Throughout their hospitalization, the patients were closely monitored. Analysis revealed no significant correlation between comorbidities and invasive mechanical ventilation (IMV) or non-invasive mechanical ventilation (NIMV). However, statistically significant associations were noted between renal and hepatic comorbidties (p = 0.009), death and CDI-SARS-CoV-2 coinfection (p = 0.09), flourochinolone treatment and CDI-SARS-CoV-2 infection (p = 0.03), and an association between diabetes mellitus and SARS-CoV-2-CDI infection (p = 0.04), as well as the need for invasive mechanical ventilation (p = 0.04). The patients with CDI treatment were significantly younger and received immuno-modulator or corticotherapy treatment, which was a risk factor for opportunistic agents. Antibiotic and PPI (proton pump inhibitor) treatment were significant risk factors for CDI coinfection, as well as for death, with PPI treatment in combination with antibiotic treatment being a more significant risk factor.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/17041
url https://fisabio.portalinvestigacion.com/publicaciones/17041
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Antibiotics-Basel
ISSN: 20796382
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
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