Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass

[EN] It is known that the insulin-like growth factor (Igf) system is involved in gonadal development and, in turn, reproduction in vertebrates. In this study, the circulating levels of Igf-1 and follicle-stimulating hormone (Fsh) were assessed as physiological signals related to gonadal maturation s...

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Autores: Sempere, Laura, Fernández, Carlos, Ibañez, Soledad, Marín, Conrado, Molés, Gregorio, Pérez-Sánchez, Jaume, Martínez, Paulino, Viñas, Ana, Felip, Alicia
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:dnet:riunet______::3e85825b12e4b23f90b428770a0cf1d8
Acceso en línea:https://riunet.upv.es/handle/10251/235154
Access Level:acceso abierto
Palabra clave:Spermatogenesis
Igf-system
Proliferation-related genes
Teleost
Aquaculture
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spelling Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bassSempere, LauraFernández, CarlosIbañez, SoledadMarín, ConradoMolés, GregorioPérez-Sánchez, JaumeMartínez, PaulinoViñas, AnaFelip, AliciaSpermatogenesisIgf-systemProliferation-related genesTeleostAquaculture[EN] It is known that the insulin-like growth factor (Igf) system is involved in gonadal development and, in turn, reproduction in vertebrates. In this study, the circulating levels of Igf-1 and follicle-stimulating hormone (Fsh) were assessed as physiological signals related to gonadal maturation stage in juvenile male European sea bass at 1 year of age. The seasonal profiles of Igf-1 and Fsh were analyzed in non-precocious (NP) and precocious (PR) fish during the early onset of puberty. Subsequently, gonadal expression patterns of the three igf genes and their two receptors, igf-1r and igf-2r, were studied during their first year of life. The analysis was continued to evaluate the mRNA expression profiles of three genes (sox17, scf, nf2) mediating spermatogenesis progression. Collectively, these results demonstrated that PR males have higher circulating levels of Igf-1 as compared to NP fish before and during the putative gonadal development period (PGD). Plasma Fsh levels were significantly higher in PR males as compared to NP fish before the start of the PGD period, although this was followed by a decrease in Fsh levels and a subsequent recovery, coinciding with the reproductive season (February). Results showed that the total variance associated with the appearance of precocity may be explained by the contribution of factors such as body size and plasma levels of Igf-1, Fsh and sex steroids in male sea bass. Expression of igfs was high during stage I, and this was significantly correlated with the expression of genes related to cell cycle progression, including sox17, scf and nf2. Finally, the decreased expression of all these gonadal factors in precocious animals suggests their potential involvement in regulating the proliferative growth of spermatogonia and supporting cells during the early stages of spermatogenesis, thus evoking the onset of puberty in male sea bass.This research was financially supported by Spanish Grants AGL2016-75400-R (PUBERTRAIT) and PID2019-109548RB-I00 (REPROBOOST), funded by MCIN/AEI/10.13039/501100011033 and ERDF, A way of making Europe, and by a grant from the Valencian Regional Government CIAICO/2022/002. L.S. was supported by an FPI fellowship (PRE2020-094920) from MICIN.ElsevierGeneralitat ValencianaAgencia Estatal de InvestigaciónEuropean Regional Development FundMinisterio de Ciencia e InnovaciónRepositorio Institucional de la Universitat Politècnica de València Riunet20252025-01-30journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/235154reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-109548RB-I00 PROPUESTAS PARA IMPULSAR EL RENDIMIENTO REPRODUCTIVO EN LA LUBINA: INTERACCION CRECIMIENTO-MADURACION Y MEJORA DE LA CALIDAD DE LOS GAMETOS A TRAVES DE LA DIETAGeneralitat Valenciana https://doi.org/10.13039/501100003359 CIAICO%2F2022%2F002Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 PRE2020-094920Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 AGL2016-75400-Ropen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:riunet______::3e85825b12e4b23f90b428770a0cf1d82026-06-13T07:49:27Z
dc.title.none.fl_str_mv Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass
title Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass
spellingShingle Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass
Sempere, Laura
Spermatogenesis
Igf-system
Proliferation-related genes
Teleost
Aquaculture
title_short Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass
title_full Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass
title_fullStr Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass
title_full_unstemmed Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass
title_sort Participation of the insulin-like growth factor system in the early maturity in juvenile male European sea bass
dc.creator.none.fl_str_mv Sempere, Laura
Fernández, Carlos
Ibañez, Soledad
Marín, Conrado
Molés, Gregorio
Pérez-Sánchez, Jaume
Martínez, Paulino
Viñas, Ana
Felip, Alicia
author Sempere, Laura
author_facet Sempere, Laura
Fernández, Carlos
Ibañez, Soledad
Marín, Conrado
Molés, Gregorio
Pérez-Sánchez, Jaume
Martínez, Paulino
Viñas, Ana
Felip, Alicia
author_role author
author2 Fernández, Carlos
Ibañez, Soledad
Marín, Conrado
Molés, Gregorio
Pérez-Sánchez, Jaume
Martínez, Paulino
Viñas, Ana
Felip, Alicia
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Generalitat Valenciana
Agencia Estatal de Investigación
European Regional Development Fund
Ministerio de Ciencia e Innovación
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Spermatogenesis
Igf-system
Proliferation-related genes
Teleost
Aquaculture
topic Spermatogenesis
Igf-system
Proliferation-related genes
Teleost
Aquaculture
description [EN] It is known that the insulin-like growth factor (Igf) system is involved in gonadal development and, in turn, reproduction in vertebrates. In this study, the circulating levels of Igf-1 and follicle-stimulating hormone (Fsh) were assessed as physiological signals related to gonadal maturation stage in juvenile male European sea bass at 1 year of age. The seasonal profiles of Igf-1 and Fsh were analyzed in non-precocious (NP) and precocious (PR) fish during the early onset of puberty. Subsequently, gonadal expression patterns of the three igf genes and their two receptors, igf-1r and igf-2r, were studied during their first year of life. The analysis was continued to evaluate the mRNA expression profiles of three genes (sox17, scf, nf2) mediating spermatogenesis progression. Collectively, these results demonstrated that PR males have higher circulating levels of Igf-1 as compared to NP fish before and during the putative gonadal development period (PGD). Plasma Fsh levels were significantly higher in PR males as compared to NP fish before the start of the PGD period, although this was followed by a decrease in Fsh levels and a subsequent recovery, coinciding with the reproductive season (February). Results showed that the total variance associated with the appearance of precocity may be explained by the contribution of factors such as body size and plasma levels of Igf-1, Fsh and sex steroids in male sea bass. Expression of igfs was high during stage I, and this was significantly correlated with the expression of genes related to cell cycle progression, including sox17, scf and nf2. Finally, the decreased expression of all these gonadal factors in precocious animals suggests their potential involvement in regulating the proliferative growth of spermatogonia and supporting cells during the early stages of spermatogenesis, thus evoking the onset of puberty in male sea bass.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-01-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/235154
url https://riunet.upv.es/handle/10251/235154
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 PID2019-109548RB-I00 PROPUESTAS PARA IMPULSAR EL RENDIMIENTO REPRODUCTIVO EN LA LUBINA: INTERACCION CRECIMIENTO-MADURACION Y MEJORA DE LA CALIDAD DE LOS GAMETOS A TRAVES DE LA DIETA
Generalitat Valenciana https://doi.org/10.13039/501100003359 CIAICO%2F2022%2F002
Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 PRE2020-094920
Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 AGL2016-75400-R
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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