Coping with Stress During Aging: The Importance of a Resilient Brain.

Resilience is the ability to achieve a positive outcome when we are in the face of adversity. It supposes an active resistance to adversity by coping mechanisms in which genetic, molecular, neural and environmental factors are involved. Resilience has been usually studied in early ages and few is kn...

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Detalles Bibliográficos
Autores: Sampedro-Piquero, P, Alvarez-Suarez, P, Begega, A
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17565
Acceso en línea:http://hdl.handle.net/20.500.12105/17565
Access Level:acceso abierto
Palabra clave:Aging
Affective disorders
Brain
Healthy lifestyle
Resilience
Stress
Adaptation, Psychological
Animals
Humans
Resilience, Psychological
Stress, Psychological
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spelling Coping with Stress During Aging: The Importance of a Resilient Brain.Sampedro-Piquero, PAlvarez-Suarez, PBegega, AAgingAffective disordersBrainHealthy lifestyleResilienceStressAdaptation, PsychologicalAgingAnimalsBrainHumansResilience, PsychologicalStress, PsychologicalResilience is the ability to achieve a positive outcome when we are in the face of adversity. It supposes an active resistance to adversity by coping mechanisms in which genetic, molecular, neural and environmental factors are involved. Resilience has been usually studied in early ages and few is known about it during aging. In this review, we will address the age-related changes in the brain mechanisms involved in regulating the stress response. Furthermore, using the EE paradigm, we analyse the resilient potential of this intervention and its neurobiological basis. In this case, we will focus on identifying the characteristics of a resilient brain (modifications in HPA structure and function, neurogenesis, specific neuron types, glia, neurotrophic factors, nitric oxide synthase or microRNAs, among others). The evidence suggests that a healthy lifestyle has a crucial role to promote a resilient brain during aging. Along with the behavioral changes described, a better regulation of HPA axis, enhanced levels of postmitotic type-3 cells or changes in GABAergic neurotransmission are some of the brain mechanisms involved in resilience. Future research should identify different biomarkers that increase the resistance to develop mood disorders and based on this knowledge, develop new potential therapeutic targets.20242024-02-0820182018-01-0120182018-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17565reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/175652026-06-12T12:43:37Z
dc.title.none.fl_str_mv Coping with Stress During Aging: The Importance of a Resilient Brain.
title Coping with Stress During Aging: The Importance of a Resilient Brain.
spellingShingle Coping with Stress During Aging: The Importance of a Resilient Brain.
Sampedro-Piquero, P
Aging
Affective disorders
Brain
Healthy lifestyle
Resilience
Stress
Adaptation, Psychological
Aging
Animals
Brain
Humans
Resilience, Psychological
Stress, Psychological
title_short Coping with Stress During Aging: The Importance of a Resilient Brain.
title_full Coping with Stress During Aging: The Importance of a Resilient Brain.
title_fullStr Coping with Stress During Aging: The Importance of a Resilient Brain.
title_full_unstemmed Coping with Stress During Aging: The Importance of a Resilient Brain.
title_sort Coping with Stress During Aging: The Importance of a Resilient Brain.
dc.creator.none.fl_str_mv Sampedro-Piquero, P
Alvarez-Suarez, P
Begega, A
author Sampedro-Piquero, P
author_facet Sampedro-Piquero, P
Alvarez-Suarez, P
Begega, A
author_role author
author2 Alvarez-Suarez, P
Begega, A
author2_role author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Aging
Affective disorders
Brain
Healthy lifestyle
Resilience
Stress
Adaptation, Psychological
Aging
Animals
Brain
Humans
Resilience, Psychological
Stress, Psychological
topic Aging
Affective disorders
Brain
Healthy lifestyle
Resilience
Stress
Adaptation, Psychological
Aging
Animals
Brain
Humans
Resilience, Psychological
Stress, Psychological
description Resilience is the ability to achieve a positive outcome when we are in the face of adversity. It supposes an active resistance to adversity by coping mechanisms in which genetic, molecular, neural and environmental factors are involved. Resilience has been usually studied in early ages and few is known about it during aging. In this review, we will address the age-related changes in the brain mechanisms involved in regulating the stress response. Furthermore, using the EE paradigm, we analyse the resilient potential of this intervention and its neurobiological basis. In this case, we will focus on identifying the characteristics of a resilient brain (modifications in HPA structure and function, neurogenesis, specific neuron types, glia, neurotrophic factors, nitric oxide synthase or microRNAs, among others). The evidence suggests that a healthy lifestyle has a crucial role to promote a resilient brain during aging. Along with the behavioral changes described, a better regulation of HPA axis, enhanced levels of postmitotic type-3 cells or changes in GABAergic neurotransmission are some of the brain mechanisms involved in resilience. Future research should identify different biomarkers that increase the resistance to develop mood disorders and based on this knowledge, develop new potential therapeutic targets.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018-01-01
2018
2018-01-01
2024
2024-02-08
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17565
url http://hdl.handle.net/20.500.12105/17565
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812455

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