Biological properties of extracellular vesicles and their physiological functions

Yanez-Mo, Maria; Siljander, Pia R. -M.; Andreu, Zoraida; Zavec, Apolonija Bedina; Borras, Francesc E.; Buzas, Edit I.; Buzas, Krisztina; Casal, Enriqueta; Cappello, Francesco; Carvalho, Joana; Colas, Eva; Cordeiro-da Silva, Anabela; Fais, Stefano; Falcon-Perez, Juan Manuel; Ghobrial, Irene M.; Giebel, Bernd; Gimona, Mario; Graner, Michael; Gursel, Ihsan; Gursel, Mayda; Heegaard, Niels H. H.; Hendrix, An; Kierulf, Peter; Kokubun, Katsutoshi; Kosanovic, Maja; Kralj-Iglic, Veronika; Kraemer-Albers, Eva-Maria; Laitinen, Saara; Lasser, Cecilia; Lener, Thomas; Ligeti, Erzsebet; Line, Aija; Lipps, Georg; Llorente, Alicia; Lotvall, Jan; Mancek-Keber, Mateja; Marcilla, Antonio; Mittelbrunn, Maria; Nazarenko, Irina; Nolte-t' Hoen, Esther N. M.; Nyman, Tuula A.; O'Driscoll, Lorraine; Olivan, Mireia; Oliveira, Carla; Pallinger, Eva; del Portillo, Hernando A.; Reventos, Jaume; Rigau, Marina; Rohde, Eva; Sammar, Marei; Sanchez-Madrid, Francisco; Santarem, N.; Schallmoser, Katharina; Ostenfeld, Marie Stampe; Stoorvogel, Willem; Stukelj, Roman; Van der Grein, Susanne G.; Helena Vasconcelos, M.; Wauben, Marca H. M.; De Wever, Olivier

Biological properties of extracellular vesicles and their physiological functions

In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functi...

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Detalles Bibliográficos
Autores:	Yanez-Mo, Maria, Siljander, Pia R. -M., Andreu, Zoraida, Zavec, Apolonija Bedina, Borras, Francesc E., Buzas, Edit I., Buzas, Krisztina, Casal, Enriqueta, Cappello, Francesco, Carvalho, Joana, Colas, Eva, Cordeiro-da Silva, Anabela, Fais, Stefano, Falcon-Perez, Juan Manuel, Ghobrial, Irene M., Giebel, Bernd, Gimona, Mario, Graner, Michael, Gursel, Ihsan, Gursel, Mayda, Heegaard, Niels H. H., Hendrix, An, Kierulf, Peter, Kokubun, Katsutoshi, Kosanovic, Maja, Kralj-Iglic, Veronika, Kraemer-Albers, Eva-Maria, Laitinen, Saara, Lasser, Cecilia, Lener, Thomas, Ligeti, Erzsebet, Line, Aija, Lipps, Georg, Llorente, Alicia, Lotvall, Jan, Mancek-Keber, Mateja, Marcilla, Antonio, Mittelbrunn, Maria, Nazarenko, Irina, Nolte-t' Hoen, Esther N. M., Nyman, Tuula A., O'Driscoll, Lorraine, Olivan, Mireia, Oliveira, Carla, Pallinger, Eva, del Portillo, Hernando A., Reventos, Jaume, Rigau, Marina, Rohde, Eva, Sammar, Marei, Sanchez-Madrid, Francisco, Santarem, N., Schallmoser, Katharina, Ostenfeld, Marie Stampe, Stoorvogel, Willem, Stukelj, Roman, Van der Grein, Susanne G., Helena Vasconcelos, M., Wauben, Marca H. M., De Wever, Olivier
Tipo de recurso:	artículo
Fecha de publicación:	2015
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/5521
Acceso en línea:	http://hdl.handle.net/20.500.12105/5521
Access Level:	acceso abierto
Palabra clave:	extracellular vesicle microvesicle microparticle exosome physiology prokaryote eukaryote OUTER-MEMBRANE VESICLES CELL-DERIVED EXOSOMES MESENCHYMAL STEM-CELLS INTESTINAL EPITHELIAL-CELLS MATURE DENDRITIC CELLS SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES IMMUNE-MODULATORY FEATURES PLANT-MICROBE INTERACTIONS FACTOR PATHWAY INHIBITOR HUMAN ENDOTHELIAL-CELLS

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spelling	Biological properties of extracellular vesicles and their physiological functionsYanez-Mo, MariaSiljander, Pia R. -M.Andreu, ZoraidaZavec, Apolonija BedinaBorras, Francesc E.Buzas, Edit I.Buzas, KrisztinaCasal, EnriquetaCappello, FrancescoCarvalho, JoanaColas, EvaCordeiro-da Silva, AnabelaFais, StefanoFalcon-Perez, Juan ManuelGhobrial, Irene M.Giebel, BerndGimona, MarioGraner, MichaelGursel, IhsanGursel, MaydaHeegaard, Niels H. H.Hendrix, AnKierulf, PeterKokubun, KatsutoshiKosanovic, MajaKralj-Iglic, VeronikaKraemer-Albers, Eva-MariaLaitinen, SaaraLasser, CeciliaLener, ThomasLigeti, ErzsebetLine, AijaLipps, GeorgLlorente, AliciaLotvall, JanMancek-Keber, MatejaMarcilla, AntonioMittelbrunn, MariaNazarenko, IrinaNolte-t' Hoen, Esther N. M.Nyman, Tuula A.O'Driscoll, LorraineOlivan, MireiaOliveira, CarlaPallinger, Evadel Portillo, Hernando A.Reventos, JaumeRigau, MarinaRohde, EvaSammar, MareiSanchez-Madrid, FranciscoSantarem, N.Schallmoser, KatharinaOstenfeld, Marie StampeStoorvogel, WillemStukelj, RomanVan der Grein, Susanne G.Helena Vasconcelos, M.Wauben, Marca H. M.De Wever, Olivierextracellular vesiclemicrovesiclemicroparticleexosomephysiologyprokaryoteeukaryoteOUTER-MEMBRANE VESICLESCELL-DERIVED EXOSOMESMESENCHYMAL STEM-CELLSINTESTINAL EPITHELIAL-CELLSMATURE DENDRITIC CELLSSYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANESIMMUNE-MODULATORY FEATURESPLANT-MICROBE INTERACTIONSFACTOR PATHWAY INHIBITORHUMAN ENDOTHELIAL-CELLSIn the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.Taylor & Francis20172017-12-0120152015-01-0120152015-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/5521reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/55212026-06-12T12:43:37Z
dc.title.none.fl_str_mv	Biological properties of extracellular vesicles and their physiological functions
title	Biological properties of extracellular vesicles and their physiological functions
spellingShingle	Biological properties of extracellular vesicles and their physiological functions Yanez-Mo, Maria extracellular vesicle microvesicle microparticle exosome physiology prokaryote eukaryote OUTER-MEMBRANE VESICLES CELL-DERIVED EXOSOMES MESENCHYMAL STEM-CELLS INTESTINAL EPITHELIAL-CELLS MATURE DENDRITIC CELLS SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES IMMUNE-MODULATORY FEATURES PLANT-MICROBE INTERACTIONS FACTOR PATHWAY INHIBITOR HUMAN ENDOTHELIAL-CELLS
title_short	Biological properties of extracellular vesicles and their physiological functions
title_full	Biological properties of extracellular vesicles and their physiological functions
title_fullStr	Biological properties of extracellular vesicles and their physiological functions
title_full_unstemmed	Biological properties of extracellular vesicles and their physiological functions
title_sort	Biological properties of extracellular vesicles and their physiological functions
dc.creator.none.fl_str_mv	Yanez-Mo, Maria Siljander, Pia R. -M. Andreu, Zoraida Zavec, Apolonija Bedina Borras, Francesc E. Buzas, Edit I. Buzas, Krisztina Casal, Enriqueta Cappello, Francesco Carvalho, Joana Colas, Eva Cordeiro-da Silva, Anabela Fais, Stefano Falcon-Perez, Juan Manuel Ghobrial, Irene M. Giebel, Bernd Gimona, Mario Graner, Michael Gursel, Ihsan Gursel, Mayda Heegaard, Niels H. H. Hendrix, An Kierulf, Peter Kokubun, Katsutoshi Kosanovic, Maja Kralj-Iglic, Veronika Kraemer-Albers, Eva-Maria Laitinen, Saara Lasser, Cecilia Lener, Thomas Ligeti, Erzsebet Line, Aija Lipps, Georg Llorente, Alicia Lotvall, Jan Mancek-Keber, Mateja Marcilla, Antonio Mittelbrunn, Maria Nazarenko, Irina Nolte-t' Hoen, Esther N. M. Nyman, Tuula A. O'Driscoll, Lorraine Olivan, Mireia Oliveira, Carla Pallinger, Eva del Portillo, Hernando A. Reventos, Jaume Rigau, Marina Rohde, Eva Sammar, Marei Sanchez-Madrid, Francisco Santarem, N. Schallmoser, Katharina Ostenfeld, Marie Stampe Stoorvogel, Willem Stukelj, Roman Van der Grein, Susanne G. Helena Vasconcelos, M. Wauben, Marca H. M. De Wever, Olivier
author	Yanez-Mo, Maria
author_facet	Yanez-Mo, Maria Siljander, Pia R. -M. Andreu, Zoraida Zavec, Apolonija Bedina Borras, Francesc E. Buzas, Edit I. Buzas, Krisztina Casal, Enriqueta Cappello, Francesco Carvalho, Joana Colas, Eva Cordeiro-da Silva, Anabela Fais, Stefano Falcon-Perez, Juan Manuel Ghobrial, Irene M. Giebel, Bernd Gimona, Mario Graner, Michael Gursel, Ihsan Gursel, Mayda Heegaard, Niels H. H. Hendrix, An Kierulf, Peter Kokubun, Katsutoshi Kosanovic, Maja Kralj-Iglic, Veronika Kraemer-Albers, Eva-Maria Laitinen, Saara Lasser, Cecilia Lener, Thomas Ligeti, Erzsebet Line, Aija Lipps, Georg Llorente, Alicia Lotvall, Jan Mancek-Keber, Mateja Marcilla, Antonio Mittelbrunn, Maria Nazarenko, Irina Nolte-t' Hoen, Esther N. M. Nyman, Tuula A. O'Driscoll, Lorraine Olivan, Mireia Oliveira, Carla Pallinger, Eva del Portillo, Hernando A. Reventos, Jaume Rigau, Marina Rohde, Eva Sammar, Marei Sanchez-Madrid, Francisco Santarem, N. Schallmoser, Katharina Ostenfeld, Marie Stampe Stoorvogel, Willem Stukelj, Roman Van der Grein, Susanne G. Helena Vasconcelos, M. Wauben, Marca H. M. De Wever, Olivier
author_role	author
author2	Siljander, Pia R. -M. Andreu, Zoraida Zavec, Apolonija Bedina Borras, Francesc E. Buzas, Edit I. Buzas, Krisztina Casal, Enriqueta Cappello, Francesco Carvalho, Joana Colas, Eva Cordeiro-da Silva, Anabela Fais, Stefano Falcon-Perez, Juan Manuel Ghobrial, Irene M. Giebel, Bernd Gimona, Mario Graner, Michael Gursel, Ihsan Gursel, Mayda Heegaard, Niels H. H. Hendrix, An Kierulf, Peter Kokubun, Katsutoshi Kosanovic, Maja Kralj-Iglic, Veronika Kraemer-Albers, Eva-Maria Laitinen, Saara Lasser, Cecilia Lener, Thomas Ligeti, Erzsebet Line, Aija Lipps, Georg Llorente, Alicia Lotvall, Jan Mancek-Keber, Mateja Marcilla, Antonio Mittelbrunn, Maria Nazarenko, Irina Nolte-t' Hoen, Esther N. M. Nyman, Tuula A. O'Driscoll, Lorraine Olivan, Mireia Oliveira, Carla Pallinger, Eva del Portillo, Hernando A. Reventos, Jaume Rigau, Marina Rohde, Eva Sammar, Marei Sanchez-Madrid, Francisco Santarem, N. Schallmoser, Katharina Ostenfeld, Marie Stampe Stoorvogel, Willem Stukelj, Roman Van der Grein, Susanne G. Helena Vasconcelos, M. Wauben, Marca H. M. De Wever, Olivier
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv	extracellular vesicle microvesicle microparticle exosome physiology prokaryote eukaryote OUTER-MEMBRANE VESICLES CELL-DERIVED EXOSOMES MESENCHYMAL STEM-CELLS INTESTINAL EPITHELIAL-CELLS MATURE DENDRITIC CELLS SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES IMMUNE-MODULATORY FEATURES PLANT-MICROBE INTERACTIONS FACTOR PATHWAY INHIBITOR HUMAN ENDOTHELIAL-CELLS
topic	extracellular vesicle microvesicle microparticle exosome physiology prokaryote eukaryote OUTER-MEMBRANE VESICLES CELL-DERIVED EXOSOMES MESENCHYMAL STEM-CELLS INTESTINAL EPITHELIAL-CELLS MATURE DENDRITIC CELLS SYNCYTIOTROPHOBLAST MICROVILLOUS MEMBRANES IMMUNE-MODULATORY FEATURES PLANT-MICROBE INTERACTIONS FACTOR PATHWAY INHIBITOR HUMAN ENDOTHELIAL-CELLS
description	In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity to transfer proteins, lipids and nucleic acids, thereby influencing various physiological and pathological functions of both recipient and parent cells. While intensive investigation has targeted the role of EVs in different pathological processes, for example, in cancer and autoimmune diseases, the EV-mediated maintenance of homeostasis and the regulation of physiological functions have remained less explored. Here, we provide a comprehensive overview of the current understanding of the physiological roles of EVs, which has been written by crowd-sourcing, drawing on the unique EV expertise of academia-based scientists, clinicians and industry based in 27 European countries, the United States and Australia. This review is intended to be of relevance to both researchers already working on EV biology and to newcomers who will encounter this universal cell biological system. Therefore, here we address the molecular contents and functions of EVs in various tissues and body fluids from cell systems to organs. We also review the physiological mechanisms of EVs in bacteria, lower eukaryotes and plants to highlight the functional uniformity of this emerging communication system.
publishDate	2015
dc.date.none.fl_str_mv	2015 2015-01-01 2015 2015-01-01 2017 2017-12-01
dc.type.none.fl_str_mv	journal article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/5521
url	http://hdl.handle.net/20.500.12105/5521
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Atribución-NoComercial 4.0 Internacional http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf
dc.publisher.none.fl_str_mv	Taylor & Francis
publisher.none.fl_str_mv	Taylor & Francis
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15.811543

Biological properties of extracellular vesicles and their physiological functions

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