Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia

Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of hypercholesterolemic subjects. Microbiota composition, SCFAs, BA and blood lipid profi...

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Autores: Granado-Serrano, Ana Belén, Martín Garí, Meritxell, Sánchez, Virginia, Riart Solans, Marissa, Berdún Hernández, Rebeca, Ludwig, Iziar A., Rubió Piqué, Laura, Vilaprinyo Terré, Ester, Portero Otín, Manuel, Serrano Casasola, José Carlos Enrique
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/65826
Acceso en línea:https://doi.org/10.1038/s41598-019-38874-3
http://hdl.handle.net/10459.1/65826
Access Level:acceso abierto
Palabra clave:Hypercholesterolemia
Faecal bacteria
short chain fatty acids
Branched short chain fatty acids
Bile acids
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spelling Faecal bacterial and short-chain fatty acids signature in hypercholesterolemiaGranado-Serrano, Ana BelénMartín Garí, MeritxellSánchez, VirginiaRiart Solans, MarissaBerdún Hernández, RebecaLudwig, Iziar A.Rubió Piqué, LauraVilaprinyo Terré, EsterPortero Otín, ManuelSerrano Casasola, José Carlos EnriqueHypercholesterolemiaFaecal bacteriashort chain fatty acidsBranched short chain fatty acidsBile acidsGut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of hypercholesterolemic subjects. Microbiota composition, SCFAs, BA and blood lipid profile from male volunteers with hypercholesterolemia (HC) and normocholesterolemia (NC) were determined by 16S rDNA sequencing, HPLC, GC and NMR, respectively. HC subjects were characterized by having lower relative abundance of Anaeroplasma (0.002% vs 0.219%, p-value = 0.026) and Haemophilus (0.041% vs 0.078%, p-value = 0.049), and higher of Odoribacter (0.51% vs 0.16%; p-value = 0.044). Correlation analysis revealed that Anaeroplasma and Haemophilus were associated to an unfavourable lipid profile: they correlated negatively to cholesterol and triglycerides related biomarkers and the ratio total to high density lipoprotein (HDL) cholesterol, and positively to HDL size. Odoribacter displayed an opposite behaviour. Faecal SCFAs profile revealed higher abundance of isobutyric (2.76% vs 0.82%, p-value = 0.049) and isovaleric acid (1.32% vs 0.06%, p-value = 0.016) in HC. Isobutyric acid correlated positively with Odoribacter and lipid parameters indicative of an unfavourable profile. BA profile did not show differences between groups. It was concluded that HC subjects showed a particular faecal bacterial signature and SCFAs profile associated with their lipid profile.The research leading to these results has received funding from the People Programme (Marie Curie Actions) of the Seventh Framework Programme of the European Union (FP7/2007-2013) under REA grant agreement No. 600388 (TECNIOspring Progamme) and from the Agency for Business Competitiveness of the Government of Catalonia ACCIÓ that support the fellowship given to Ana Belén Granado-Serrano (TECSPR14-0-0023). I.A.L enjoys a post-doctoral contract (2017PMF-POST2-19) from the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement and from the Universitat Rovira i Virgili (URV).Nature Research2019201920192019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1038/s41598-019-38874-3http://hdl.handle.net/10459.1/65826http://hdl.handle.net/10459.1/65826reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1038/s41598-019-38874-3Scientific Reports, 2019, vol. 9, núm. 1772, p. 1-13info:eu-repo/grantAgreement/EC/FP7/600388cc-by (c) Granado-Serrano, Ana Belén et al., 2019info:eu-repo/semantics/openAccesshttp://creativecommons.org/licenses/by/3.0/esoai:recercat.cat:10459.1/658262026-05-29T05:05:01Z
dc.title.none.fl_str_mv Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
title Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
spellingShingle Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
Granado-Serrano, Ana Belén
Hypercholesterolemia
Faecal bacteria
short chain fatty acids
Branched short chain fatty acids
Bile acids
title_short Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
title_full Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
title_fullStr Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
title_full_unstemmed Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
title_sort Faecal bacterial and short-chain fatty acids signature in hypercholesterolemia
dc.creator.none.fl_str_mv Granado-Serrano, Ana Belén
Martín Garí, Meritxell
Sánchez, Virginia
Riart Solans, Marissa
Berdún Hernández, Rebeca
Ludwig, Iziar A.
Rubió Piqué, Laura
Vilaprinyo Terré, Ester
Portero Otín, Manuel
Serrano Casasola, José Carlos Enrique
author Granado-Serrano, Ana Belén
author_facet Granado-Serrano, Ana Belén
Martín Garí, Meritxell
Sánchez, Virginia
Riart Solans, Marissa
Berdún Hernández, Rebeca
Ludwig, Iziar A.
Rubió Piqué, Laura
Vilaprinyo Terré, Ester
Portero Otín, Manuel
Serrano Casasola, José Carlos Enrique
author_role author
author2 Martín Garí, Meritxell
Sánchez, Virginia
Riart Solans, Marissa
Berdún Hernández, Rebeca
Ludwig, Iziar A.
Rubió Piqué, Laura
Vilaprinyo Terré, Ester
Portero Otín, Manuel
Serrano Casasola, José Carlos Enrique
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hypercholesterolemia
Faecal bacteria
short chain fatty acids
Branched short chain fatty acids
Bile acids
topic Hypercholesterolemia
Faecal bacteria
short chain fatty acids
Branched short chain fatty acids
Bile acids
description Gut microbiota has been suggested to affect lipid metabolism. The objective of this study was to characterize the faecal microbiota signature and both short chain fatty acids (SCFAs) and bile acids (BA) profile of hypercholesterolemic subjects. Microbiota composition, SCFAs, BA and blood lipid profile from male volunteers with hypercholesterolemia (HC) and normocholesterolemia (NC) were determined by 16S rDNA sequencing, HPLC, GC and NMR, respectively. HC subjects were characterized by having lower relative abundance of Anaeroplasma (0.002% vs 0.219%, p-value = 0.026) and Haemophilus (0.041% vs 0.078%, p-value = 0.049), and higher of Odoribacter (0.51% vs 0.16%; p-value = 0.044). Correlation analysis revealed that Anaeroplasma and Haemophilus were associated to an unfavourable lipid profile: they correlated negatively to cholesterol and triglycerides related biomarkers and the ratio total to high density lipoprotein (HDL) cholesterol, and positively to HDL size. Odoribacter displayed an opposite behaviour. Faecal SCFAs profile revealed higher abundance of isobutyric (2.76% vs 0.82%, p-value = 0.049) and isovaleric acid (1.32% vs 0.06%, p-value = 0.016) in HC. Isobutyric acid correlated positively with Odoribacter and lipid parameters indicative of an unfavourable profile. BA profile did not show differences between groups. It was concluded that HC subjects showed a particular faecal bacterial signature and SCFAs profile associated with their lipid profile.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1038/s41598-019-38874-3
http://hdl.handle.net/10459.1/65826
http://hdl.handle.net/10459.1/65826
url https://doi.org/10.1038/s41598-019-38874-3
http://hdl.handle.net/10459.1/65826
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1038/s41598-019-38874-3
Scientific Reports, 2019, vol. 9, núm. 1772, p. 1-13
info:eu-repo/grantAgreement/EC/FP7/600388
dc.rights.none.fl_str_mv cc-by (c) Granado-Serrano, Ana Belén et al., 2019
info:eu-repo/semantics/openAccess
http://creativecommons.org/licenses/by/3.0/es
rights_invalid_str_mv cc-by (c) Granado-Serrano, Ana Belén et al., 2019
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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