Tumor Imaging Using Radiolabeled Matrix Metalloproteinase-Activated Anthrax Proteins

Increased activity of matrix metalloproteinases (MMPs) is associated with worse prognosis in different cancer types. The wild-type protective antigen (PA-WT) of the binary anthrax lethal toxin was modified to form a pore in cell membranes only when cleaved by MMPs (to form PA-L1). Anthrax lethal fac...

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Detalles Bibliográficos
Autores: Elvina Xavier, Mary-Ann, Liu, Shihui, Bugge, Thomas H., Baguña Torres, Júlia, Mosley, Michael, Hopkins, Samantha L., Allen, Phillip D., Berridge, Georgina, Vendrell, Iolanda, Fischer, Roman, Kersemans, Veerle, Smart, Sean, Leppla, Stephen H., Cornelissen, Bart
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/419887
Acceso en línea:http://hdl.handle.net/10261/419887
https://api.elsevier.com/content/abstract/scopus_id/85069569706
Access Level:acceso abierto
Palabra clave:MMP
SPECT
Anthrax lethal toxin
Cancer
Pretargeting
Descripción
Sumario:Increased activity of matrix metalloproteinases (MMPs) is associated with worse prognosis in different cancer types. The wild-type protective antigen (PA-WT) of the binary anthrax lethal toxin was modified to form a pore in cell membranes only when cleaved by MMPs (to form PA-L1). Anthrax lethal factor (LF) is then able to translocate through these pores. Here, we used a 111In-radiolabeled form of LF with the PA/LF system for noninvasive in vivo imaging of MMP activity in tumor tissue by SPECT.

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