Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies

Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ malignancies. However, serious side effects have been associated with its use, such as bilateral, progressive, irreversible, dose-dependent neurosensory hearing loss. Current evidence indicates that cispl...

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Detalles Bibliográficos
Autores: Callejo Castillo, Àngela, Sedó Cabezón, Lara, Doménech Juan, Ivan, Llorens i Baucells, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2015
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/110751
Acceso en línea:https://hdl.handle.net/2445/110751
Access Level:acceso abierto
Palabra clave:Cisplatí
Medicaments antineoplàstics
Efectes secundaris dels medicaments
Toxicitat dels medicaments
Trastorns auditius
Sordesa
Ressenyes sistemàtiques (Investigació mèdica)
Cisplatin
Antineoplastic agents
Drug side effects
Drug toxicity
Hearing disorders
Deafness
Systematic reviews (Medical research)
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spelling Cisplatin-induced ototoxicity: effects, mechanisms and protection strategiesCallejo Castillo, ÀngelaSedó Cabezón, LaraDoménech Juan, IvanLlorens i Baucells, JordiCisplatíMedicaments antineoplàsticsEfectes secundaris dels medicamentsToxicitat dels medicamentsTrastorns auditiusSordesaRessenyes sistemàtiques (Investigació mèdica)CisplatinAntineoplastic agentsDrug side effectsDrug toxicityHearing disordersDeafnessSystematic reviews (Medical research)Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ malignancies. However, serious side effects have been associated with its use, such as bilateral, progressive, irreversible, dose-dependent neurosensory hearing loss. Current evidence indicates that cisplatin triggers the production of reactive oxygen species in target tissues in the inner ear. A variety of agents that protect against cisplatin-induced ototoxicity have been successfully tested in cell culture and animal models. However, many of them interfere with the therapeutic effect of cisplatin, and therefore are not suitable for systemic administration in clinical practice. Consequently, local administration strategies, namely intratympanic adminis- tration, have been developed to achieve otoprotection, without reducing the antitumoral effect of cisplatin. While a considerable amount of pre-clinical information is available, clinical data on treatments to prevent cisplatin ototoxicity are only just beginning to appear. This review summarizes clinical and experimental studies of cisplatin ototoxicity, and focuses on understanding its toxicity mechanisms, clinical repercussions and prevention strategies.MDPI2017201720152017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion26 p.application/pdfhttps://hdl.handle.net/2445/110751Articles publicats en revistes (Ciències Fisiològiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/toxics3030268Toxics, 2015, vol. 3, p. 268-293https://doi.org/10.3390/toxics3030268cc-by (c) Callejo, Angela et al., 2015http://creativecommons.org/licenses/by/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1107512026-05-29T05:05:01Z
dc.title.none.fl_str_mv Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies
title Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies
spellingShingle Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies
Callejo Castillo, Àngela
Cisplatí
Medicaments antineoplàstics
Efectes secundaris dels medicaments
Toxicitat dels medicaments
Trastorns auditius
Sordesa
Ressenyes sistemàtiques (Investigació mèdica)
Cisplatin
Antineoplastic agents
Drug side effects
Drug toxicity
Hearing disorders
Deafness
Systematic reviews (Medical research)
title_short Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies
title_full Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies
title_fullStr Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies
title_full_unstemmed Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies
title_sort Cisplatin-induced ototoxicity: effects, mechanisms and protection strategies
dc.creator.none.fl_str_mv Callejo Castillo, Àngela
Sedó Cabezón, Lara
Doménech Juan, Ivan
Llorens i Baucells, Jordi
author Callejo Castillo, Àngela
author_facet Callejo Castillo, Àngela
Sedó Cabezón, Lara
Doménech Juan, Ivan
Llorens i Baucells, Jordi
author_role author
author2 Sedó Cabezón, Lara
Doménech Juan, Ivan
Llorens i Baucells, Jordi
author2_role author
author
author
dc.subject.none.fl_str_mv Cisplatí
Medicaments antineoplàstics
Efectes secundaris dels medicaments
Toxicitat dels medicaments
Trastorns auditius
Sordesa
Ressenyes sistemàtiques (Investigació mèdica)
Cisplatin
Antineoplastic agents
Drug side effects
Drug toxicity
Hearing disorders
Deafness
Systematic reviews (Medical research)
topic Cisplatí
Medicaments antineoplàstics
Efectes secundaris dels medicaments
Toxicitat dels medicaments
Trastorns auditius
Sordesa
Ressenyes sistemàtiques (Investigació mèdica)
Cisplatin
Antineoplastic agents
Drug side effects
Drug toxicity
Hearing disorders
Deafness
Systematic reviews (Medical research)
description Cisplatin is a highly effective chemotherapeutic agent that is widely used to treat solid organ malignancies. However, serious side effects have been associated with its use, such as bilateral, progressive, irreversible, dose-dependent neurosensory hearing loss. Current evidence indicates that cisplatin triggers the production of reactive oxygen species in target tissues in the inner ear. A variety of agents that protect against cisplatin-induced ototoxicity have been successfully tested in cell culture and animal models. However, many of them interfere with the therapeutic effect of cisplatin, and therefore are not suitable for systemic administration in clinical practice. Consequently, local administration strategies, namely intratympanic adminis- tration, have been developed to achieve otoprotection, without reducing the antitumoral effect of cisplatin. While a considerable amount of pre-clinical information is available, clinical data on treatments to prevent cisplatin ototoxicity are only just beginning to appear. This review summarizes clinical and experimental studies of cisplatin ototoxicity, and focuses on understanding its toxicity mechanisms, clinical repercussions and prevention strategies.
publishDate 2015
dc.date.none.fl_str_mv 2015
2017
2017
2017
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/110751
url https://hdl.handle.net/2445/110751
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/toxics3030268
Toxics, 2015, vol. 3, p. 268-293
https://doi.org/10.3390/toxics3030268
dc.rights.none.fl_str_mv cc-by (c) Callejo, Angela et al., 2015
http://creativecommons.org/licenses/by/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Callejo, Angela et al., 2015
http://creativecommons.org/licenses/by/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 26 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Fisiològiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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