Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.

The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2-ERIC-PPCI outcome stu...

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Autores: Bell, R M, Basalay, M, Bøtker, H E, Beikoghli Kalkhoran, S, Carr, R D, Cunningham, J, Davidson, S M, England, T J, Giesz, S, Ghosh, A K, Golforoush, P, Gourine, A V, Hausenloy, D J, Heusch, G, Ibáñez, Borja, Kleinbongard, P, Lecour, S, Lukhna, K, Ntsekhe, M, Ovize, M, Salama, A D, Vilahur, G, Walker, J M, Yellon, D M
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/15776
Acceso en línea:http://hdl.handle.net/20.500.12105/15776
Access Level:acceso abierto
Palabra clave:Brain Ischemia
COVID-19
Ischemic Preconditioning, Myocardial
Stroke
Animals
Education
Ischemia
Treatment Outcome
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spelling Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.Bell, R MBasalay, MBøtker, H EBeikoghli Kalkhoran, SCarr, R DCunningham, JDavidson, S MEngland, T JGiesz, SGhosh, A KGolforoush, PGourine, A VHausenloy, D JHeusch, GIbáñez, BorjaKleinbongard, PLecour, SLukhna, KNtsekhe, MOvize, MSalama, A DVilahur, GWalker, J MYellon, D MBrain IschemiaCOVID-19Ischemic Preconditioning, MyocardialStrokeAnimalsEducationIschemiaTreatment OutcomeThe Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2-ERIC-PPCI outcome study which demonstrated no additional benefit when using RIC in the setting of ST-elevation myocardial infarction (STEMI). The workshop discussed how conditioning has led to a significant and fundamental understanding of the mechanisms preventing cell death following ischaemia and reperfusion, and the key target cyto-protective pathways recruited by protective interventions, such as RIC. However, the obvious need to translate this protection to the clinical setting has not materialised largely due to the disconnect between preclinical and clinical studies. Discussion points included how to adapt preclinical animal studies to mirror the patient presenting with an acute myocardial infarction, as well as how to refine patient selection in clinical studies to account for co-morbidities and ongoing therapy. These latter scenarios can modify cytoprotective signalling and need to be taken into account to allow for a more robust outcome when powered appropriately. The workshop also discussed the potential for RIC in other disease settings including ischaemic stroke, cardio-oncology and COVID-19. The workshop, therefore, put forward specific classifications which could help identify so-called responders vs. non-responders in both the preclinical and clinical settings.SpringerBritish Heart FoundationUnión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)Ministerio de Ciencia e Innovación (España)20232023-04-1220222022-08-1520222022-08-15journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/15776reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 4.0 Internacionalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/157762026-06-12T12:43:37Z
dc.title.none.fl_str_mv Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.
title Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.
spellingShingle Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.
Bell, R M
Brain Ischemia
COVID-19
Ischemic Preconditioning, Myocardial
Stroke
Animals
Education
Ischemia
Treatment Outcome
title_short Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.
title_full Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.
title_fullStr Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.
title_full_unstemmed Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.
title_sort Remote ischaemic conditioning: defining critical criteria for success-report from the 11th Hatter Cardiovascular Workshop.
dc.creator.none.fl_str_mv Bell, R M
Basalay, M
Bøtker, H E
Beikoghli Kalkhoran, S
Carr, R D
Cunningham, J
Davidson, S M
England, T J
Giesz, S
Ghosh, A K
Golforoush, P
Gourine, A V
Hausenloy, D J
Heusch, G
Ibáñez, Borja
Kleinbongard, P
Lecour, S
Lukhna, K
Ntsekhe, M
Ovize, M
Salama, A D
Vilahur, G
Walker, J M
Yellon, D M
author Bell, R M
author_facet Bell, R M
Basalay, M
Bøtker, H E
Beikoghli Kalkhoran, S
Carr, R D
Cunningham, J
Davidson, S M
England, T J
Giesz, S
Ghosh, A K
Golforoush, P
Gourine, A V
Hausenloy, D J
Heusch, G
Ibáñez, Borja
Kleinbongard, P
Lecour, S
Lukhna, K
Ntsekhe, M
Ovize, M
Salama, A D
Vilahur, G
Walker, J M
Yellon, D M
author_role author
author2 Basalay, M
Bøtker, H E
Beikoghli Kalkhoran, S
Carr, R D
Cunningham, J
Davidson, S M
England, T J
Giesz, S
Ghosh, A K
Golforoush, P
Gourine, A V
Hausenloy, D J
Heusch, G
Ibáñez, Borja
Kleinbongard, P
Lecour, S
Lukhna, K
Ntsekhe, M
Ovize, M
Salama, A D
Vilahur, G
Walker, J M
Yellon, D M
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv British Heart Foundation
Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Ministerio de Ciencia e Innovación (España)
dc.subject.none.fl_str_mv Brain Ischemia
COVID-19
Ischemic Preconditioning, Myocardial
Stroke
Animals
Education
Ischemia
Treatment Outcome
topic Brain Ischemia
COVID-19
Ischemic Preconditioning, Myocardial
Stroke
Animals
Education
Ischemia
Treatment Outcome
description The Hatter Cardiovascular Institute biennial workshop, originally scheduled for April 2020 but postponed for 2 years due to the Covid pandemic, was organised to debate and discuss the future of Remote Ischaemic Conditioning (RIC). This evolved from the large multicentre CONDI-2-ERIC-PPCI outcome study which demonstrated no additional benefit when using RIC in the setting of ST-elevation myocardial infarction (STEMI). The workshop discussed how conditioning has led to a significant and fundamental understanding of the mechanisms preventing cell death following ischaemia and reperfusion, and the key target cyto-protective pathways recruited by protective interventions, such as RIC. However, the obvious need to translate this protection to the clinical setting has not materialised largely due to the disconnect between preclinical and clinical studies. Discussion points included how to adapt preclinical animal studies to mirror the patient presenting with an acute myocardial infarction, as well as how to refine patient selection in clinical studies to account for co-morbidities and ongoing therapy. These latter scenarios can modify cytoprotective signalling and need to be taken into account to allow for a more robust outcome when powered appropriately. The workshop also discussed the potential for RIC in other disease settings including ischaemic stroke, cardio-oncology and COVID-19. The workshop, therefore, put forward specific classifications which could help identify so-called responders vs. non-responders in both the preclinical and clinical settings.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-08-15
2022
2022-08-15
2023
2023-04-12
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/15776
url http://hdl.handle.net/20.500.12105/15776
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 4.0 Internacional
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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