Asthma-COPD overlap is not a homogeneous disorder: further supporting data
Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classifi...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Conselleria de Salut i Consum del Govern de les Illes Balears |
| Repositorio: | Docusalut |
| Idioma: | inglés |
| OAI Identifier: | oai:docusalut.com:20.500.13003/9560 |
| Acceso en línea: | https://hdl.handle.net/20.500.13003/9560 |
| Access Level: | acceso abierto |
| Palabra clave: | Pulmonary Disease, Chronic Obstructive Cross-Sectional Studies Middle Aged Forced Expiratory Volume Humans Female Inflammation Mediators Male Aged Eosinophils Asthma Eosinófilos Anciano Enfermedad Pulmonar Obstructiva Crónica Humanos Mediadores de Inflamación Estudios Transversales Femenino Asma Volumen Espiratorio Forzado Persona de Mediana Edad Masculino Periostin COPD Asthma-COPD overlap ACO |
| Sumario: | Asthma-COPD ovelap (ACO) is an umbrella term that encompasses patients with COPD and eosinophilic inflammation (e-COPD) and smoking asthmatics with non-fully reversible airflow obstruction (SA). We compared the clinical characteristics and the inflammatory profile of e-COPD and SA. Patients classified as e-COPD were older and more often male and showed significantly impaired pulmonary function (likely explained by a heavier smoking habit). On the contrary, SA had more atopic features, more reversibility of airflow obstruction and higher IgE levels. The concentrations of IL-5, IL-13, IL-8, IL-6, TNF-alpha, IL17 in serum were similar between the 2 groups. However, Th2-related biomarkers (periostin, FeNO and blood eosinophils) shower higher median values in e-COPD patients. Our findings reinforce the notion that ACO is a heterogeneous disorder and, as a consequence, it might be unacceptable to offer the same treatment for two related but different conditions. |
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