Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer

The distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented but this re...

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Autores: Retegui Goñi, Garazi, Etxeberria Andueza, Jaione, Ugarte Martínez, María Dolores
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Universidad Pública de Navarra
Repositorio:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
OAI Identifier:oai:academica-e.unavarra.es:2454/42691
Acceso en línea:https://hdl.handle.net/2454/42691
Access Level:acceso abierto
Palabra clave:Cancer
Mortality rates
Incidence
Predictions
Statistics
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spelling Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancerRetegui Goñi, GaraziEtxeberria Andueza, JaioneUgarte Martínez, María DoloresCancerMortality ratesIncidencePredictionsStatisticsThe distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented but this requires a clear specification of the target population. This paper provides an in-depth description of LOCP mortality rates by province, age group and gender, giving a complete overview of the disease. This study also presents a methodological challenge. As the number of LOCP cancer cases in small domains (province, age groups and gender) is scarce, univariate spatial models do not provide reliable results or are even impossible to fit. In view of the close link between LOCP and lung cancer, we consider analyzing them jointly by using shared component models. These models allow information-borrowing among diseases, ultimately providing the analysis of cancer sites with few cases at a very disaggregated level. Results show that males have higher mortality rates than females and these rates increase with age. Regions located in the north of Spain show the highest LOCP cancer mortality rates.The work was supported by Project MTM2017-82553-R (AEI, UE), Project PID2020-113125RB-I00/MCIN/ AEI/10.13039/501100011033 and Proyecto Jóvenes Investigadores PJUPNA2018-11.Nature ResearchEstatistika, Informatika eta MatematikaInstitute for Advanced Materials and Mathematics - INAMAT2Estadística, Informática y MatemáticasUniversidad Pública de Navarra / Nafarroako Unibertsitate Publikoa2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2454/42691reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarrainstname:Universidad Pública de NavarraInglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MTM2017-82553-Rinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113125RB-I00Creative Commons Attribution 4.0 Internationalhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:academica-e.unavarra.es:2454/426912026-06-17T12:41:47Z
dc.title.none.fl_str_mv Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
spellingShingle Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
Retegui Goñi, Garazi
Cancer
Mortality rates
Incidence
Predictions
Statistics
title_short Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_full Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_fullStr Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_full_unstemmed Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
title_sort Estimating LOCP cancer mortality rates in small domains in Spain using its relationship with lung cancer
dc.creator.none.fl_str_mv Retegui Goñi, Garazi
Etxeberria Andueza, Jaione
Ugarte Martínez, María Dolores
author Retegui Goñi, Garazi
author_facet Retegui Goñi, Garazi
Etxeberria Andueza, Jaione
Ugarte Martínez, María Dolores
author_role author
author2 Etxeberria Andueza, Jaione
Ugarte Martínez, María Dolores
author2_role author
author
dc.contributor.none.fl_str_mv Estatistika, Informatika eta Matematika
Institute for Advanced Materials and Mathematics - INAMAT2
Estadística, Informática y Matemáticas
Universidad Pública de Navarra / Nafarroako Unibertsitate Publikoa
dc.subject.none.fl_str_mv Cancer
Mortality rates
Incidence
Predictions
Statistics
topic Cancer
Mortality rates
Incidence
Predictions
Statistics
description The distribution of lip, oral cavity, and pharynx (LOCP) cancer mortality rates in small domains (defined as the combination of province, age group, and gender) remains unknown in Spain. As many of the LOCP risk factors are preventable, specific prevention programmes could be implemented but this requires a clear specification of the target population. This paper provides an in-depth description of LOCP mortality rates by province, age group and gender, giving a complete overview of the disease. This study also presents a methodological challenge. As the number of LOCP cancer cases in small domains (province, age groups and gender) is scarce, univariate spatial models do not provide reliable results or are even impossible to fit. In view of the close link between LOCP and lung cancer, we consider analyzing them jointly by using shared component models. These models allow information-borrowing among diseases, ultimately providing the analysis of cancer sites with few cases at a very disaggregated level. Results show that males have higher mortality rates than females and these rates increase with age. Regions located in the north of Spain show the highest LOCP cancer mortality rates.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2454/42691
url https://hdl.handle.net/2454/42691
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/MTM2017-82553-R
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2020-113125RB-I00
dc.rights.none.fl_str_mv Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Nature Research
publisher.none.fl_str_mv Nature Research
dc.source.none.fl_str_mv reponame:Academica-e. Repositorio Institucional de la Universidad Pública de Navarra
instname:Universidad Pública de Navarra
instname_str Universidad Pública de Navarra
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