African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update

34 Pág.

Detalles Bibliográficos
Autores: Franzoni, Giulia, Pedrera, Miriam, Sánchez-Cordón, Pedro J.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/308255
Acceso en línea:http://hdl.handle.net/10261/308255
https://api.elsevier.com/content/abstract/scopus_id/85147046402
Access Level:acceso abierto
Palabra clave:African swine fever
Chemokines
Cytokines
Interferons
Interleukins
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spelling African Swine Fever Virus Infection and Cytokine Response In Vivo: An UpdateFranzoni, GiuliaPedrera, MiriamSánchez-Cordón, Pedro J.African swine feverChemokinesCytokinesInterferonsInterleukins34 Pág.African swine fever (ASF) is a hemorrhagic viral disease of domestic pigs and wild suids (all Sus scrofa) caused by the ASF virus (ASFV). The disease is spreading worldwide without control, threatening pig production due to the absence of licensed vaccine or commercially available treatments. A thorough understanding of the immunopathogenic mechanisms behind ASFV infection is required to better fight the disease. Cytokines are small, non-structural proteins, which play a crucial role in many aspects of the immune responses to viruses, including ASFV. Infection with virulent ASFV isolates often results in exacerbated immune responses, with increased levels of serum pro-inflammatory interleukins (IL-1α, IL-1β, IL-6), TNF and chemokines (CCL2, CCL5, CXCL10). Increased levels of IL-1, IL-6 and TNF are often detected in several tissues during acute ASFV infections and associated with lymphoid depletion, hemorrhages and oedemas. IL-1Ra is frequently released during ASFV infection to block further IL-1 activity, with its implication in ASFV immunopathology having been suggested. Increased levels of IFN-α and of the anti-inflammatory IL-10 seem to be negatively correlated with animal survival, whereas some correlation between virus-specific IFN-γ-producing cells and protection has been suggested in different studies where different vaccine candidates were tested, although future works should elucidate whether IFN-γ release by specific cell types is related to protection or disease development.Authors would like to thank the Italian Ministry of Health (grant IZS SA 06/21) for funding. Authors would like to thank the support received from the European project VACDIVA (EU-H2020-862874).Peer reviewedMultidisciplinary Digital Publishing InstituteMinistero della SaluteEuropean CommissionFranzoni, Giulia [0000-0003-0987-3863]Pedrera, Miriam [0000-0003-4868-6630]Sánchez-Cordón, P. J. [0000-0002-7202-6475]Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202320232023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_dcae04bcPublisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/308255https://api.elsevier.com/content/abstract/scopus_id/85147046402reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/H2020/862874Centro de Investigación en Sanidad Animal (CISA)https://doi.org/10.3390/v15010233Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3082552026-05-22T06:33:51Z
dc.title.none.fl_str_mv African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
spellingShingle African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
Franzoni, Giulia
African swine fever
Chemokines
Cytokines
Interferons
Interleukins
title_short African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title_full African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title_fullStr African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title_full_unstemmed African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
title_sort African Swine Fever Virus Infection and Cytokine Response In Vivo: An Update
dc.creator.none.fl_str_mv Franzoni, Giulia
Pedrera, Miriam
Sánchez-Cordón, Pedro J.
author Franzoni, Giulia
author_facet Franzoni, Giulia
Pedrera, Miriam
Sánchez-Cordón, Pedro J.
author_role author
author2 Pedrera, Miriam
Sánchez-Cordón, Pedro J.
author2_role author
author
dc.contributor.none.fl_str_mv Ministero della Salute
European Commission
Franzoni, Giulia [0000-0003-0987-3863]
Pedrera, Miriam [0000-0003-4868-6630]
Sánchez-Cordón, P. J. [0000-0002-7202-6475]
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv African swine fever
Chemokines
Cytokines
Interferons
Interleukins
topic African swine fever
Chemokines
Cytokines
Interferons
Interleukins
description 34 Pág.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_dcae04bc
Publisher's version
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format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/308255
https://api.elsevier.com/content/abstract/scopus_id/85147046402
url http://hdl.handle.net/10261/308255
https://api.elsevier.com/content/abstract/scopus_id/85147046402
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/H2020/862874
Centro de Investigación en Sanidad Animal (CISA)
https://doi.org/10.3390/v15010233
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
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instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
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