Adipokines as New Biomarkers of Immune Recovery

A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4 T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This...

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Bibliographic Details
Authors: Yeregui, Elena|||0000-0003-2994-4219, Masip, Jenifer|||0000-0002-9233-5195, Viladés, Consuelo|||0000-0002-2991-9593, Domingo Pedrol, Pedro|||0000-0003-1138-5770, Pacheco, Yolanda M.|||0000-0002-9451-8083, Blanco, Julià|||0000-0002-2225-0217, Mallolas Masferrer, Josep|||0000-0002-8365-141X, Alba, Verónica|||0000-0002-5925-9573, Vargas Laguna, Montserrat|||0000-0001-7650-0587, García-Pardo, Graciano|||0000-0003-0274-6001, Negredo Puigmal, Eugènia|||0000-0001-5298-1734, Olona, Montserrat|||0000-0001-5303-9361, Vidal-González, Judit, Peraire, Maria, Martí, Anna, Reverté Calvet, Laia|||0000-0003-4690-2387, Gómez-Bertomeu, Fréderic|||0000-0002-8039-2889, Leal, Manuel, Vidal, Francesc|||0000-0002-6692-6186, Peraire, Joaquim|||0000-0001-7808-5479, Rull, Anna|||0000-0002-8907-7754
Format: article
Publication Date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:290611
Online Access:https://ddd.uab.cat/record/290611
https://dx.doi.org/urn:doi:10.3390/ijms23042202
Access Level:Open access
Keyword:Adipokines
Antiretroviral therapy
HIV
Immunodiscordant response
Poor immune recovery
Description
Summary:A significant proportion of people living with HIV (PLHIV) who successfully achieve virological suppression fail to recover CD4 T-cell counts. Since adipose tissue has been discovered as a key immune organ, this study aimed to assess the role of adipokines in the HIV immunodiscordant response. This is a multicenter prospective study including 221 PLHIV starting the first antiretroviral therapy (ART) and classified according to baseline CD4 T-cell counts/µL (controls.

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