Monitoring of first-line drug resistance mutations outside the scope of Xpert MTB/RIF Ultra is needed for successful control of DR-TB in Southern Mozambique

Multidrug-resistant(MDR) tuberculosis in Southern Africa is of great concern, exacerbated by the spread of a clone harboring a mutation missed by Xpert Ultra. In Southern Mozambique, the presence of such mutation and rising cases of non-MDR isoniazid resistance highlights the need to ensure accurate...

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Detalles Bibliográficos
Autores: Mariner-Llicer, Carla, Saavedra Cervera, Belén, Mambuque, Edson, Gomes, Neide, Munguambe, Shilzia, Villamayor, Luis M., Cancino-Muñoz, Irving, Torres-Puente, Manuela, Nguenha, Dinis, Respeito, Durval, Tembe, Gustavo, López, Mariana G., Comas, Iñaki, García-Basteiro, Alberto L.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/356637
Acceso en línea:http://hdl.handle.net/10261/356637
Access Level:acceso abierto
Palabra clave:Mycobacterium tuberculosis
Mozambique
Resistance conferring mutations
Whole-genome sequencing
Descripción
Sumario:Multidrug-resistant(MDR) tuberculosis in Southern Africa is of great concern, exacerbated by the spread of a clone harboring a mutation missed by Xpert Ultra. In Southern Mozambique, the presence of such mutation and rising cases of non-MDR isoniazid resistance highlights the need to ensure accurate detection of antimicrobial-resistance in the country.

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