Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults

Objectives: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people >= 65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. Methods: During 2014-...

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Autores: Ciruela, P, Broner, S, Izquierdo, C, Pallares, R, Munoz-Almagro, C, Hernandez, S, Grau, I, Dominguez, A, Jane, M, Esteva, C, de Sevilla, MF, Henares, D, Ardanuy, C, Marco, F, Margall, N, Gonzalez-Cuevas, A, Diaz, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p13759
Acceso en línea:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13759
Access Level:acceso abierto
Palabra clave:Streptococcus pneumoniae
IPD
PCV13
Adults
Case fatality rate
Comorbidities
Mortality
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spelling Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adultsCiruela, PBroner, SIzquierdo, CPallares, RMunoz-Almagro, CHernandez, SGrau, IDominguez, AJane, MEsteva, Cde Sevilla, MFHenares, DArdanuy, CMarco, FMargall, NGonzalez-Cuevas, ADiaz, AStreptococcus pneumoniaeIPDPCV13AdultsCase fatality rateComorbiditiesMortalityObjectives: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people >= 65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. Methods: During 2014-2016, 1285 IPD cases were reported to the Public Health Agency of Catalonia. The indirect effect of paediatric PCV13 vaccination was calculated by comparing the incidence rate (IR) in 2016 (PCV13 year) with that in 2009 (pre-PCV13). Predictors of mortality were determined using multivariate logistic regression. Results: Comparing 2016 and 2009, IPD decreased by 19% (IR 40.1 and 32.5 per 100 000 person-years, respectively). PCV13 serotypes decreased by 57% (IR 23.7 and 10.1), while non-PCV13 serotypes increased by 36% (IR 16.4 and 22.4). During 2014-2016, the mortality rate was 17.5%, and mortality was associated with age >= 85 years (adjusted odds ratio (aOR) 2.91, 95% confidence interval (CI) 1.89, 4.48), meningitis (aOR 2.29, 95% CI 1.25, 4.19), non-focal bacteraemia (aOR 3.73, 95% CI 2.00, 6.94), and >= 1 high-risk condition (aOR 1.89, 95% CI 1.08, 3.32). PPV23non13 serotypes were associated with lower mortality than PCV13 serotypes (aOR 0.54, 95% CI 0.34, 0.86). Conclusions: The incidence of IPD in people >= 65 years of age decreased after the introduction of paediatric PCV13, and this was due to a reduction in PCV13 serotypes, although an increase in non-PCV13 serotypes was observed. Mortality was associated with age, meningitis, non-focal bacteraemia, >= 1 high-risk condition, and PCV13 serotypes. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.ELSEVIER SCI LTD2019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13759INTERNATIONAL JOURNAL OF INFECTIOUS DISEASESISSN: 12019712ISSNe: 18783511reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p137592026-06-14T12:41:47Z
dc.title.none.fl_str_mv Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
spellingShingle Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
Ciruela, P
Streptococcus pneumoniae
IPD
PCV13
Adults
Case fatality rate
Comorbidities
Mortality
title_short Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title_full Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title_fullStr Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title_full_unstemmed Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
title_sort Indirect effects of paediatric conjugate vaccines on invasive pneumococcal disease in older adults
dc.creator.none.fl_str_mv Ciruela, P
Broner, S
Izquierdo, C
Pallares, R
Munoz-Almagro, C
Hernandez, S
Grau, I
Dominguez, A
Jane, M
Esteva, C
de Sevilla, MF
Henares, D
Ardanuy, C
Marco, F
Margall, N
Gonzalez-Cuevas, A
Diaz, A
author Ciruela, P
author_facet Ciruela, P
Broner, S
Izquierdo, C
Pallares, R
Munoz-Almagro, C
Hernandez, S
Grau, I
Dominguez, A
Jane, M
Esteva, C
de Sevilla, MF
Henares, D
Ardanuy, C
Marco, F
Margall, N
Gonzalez-Cuevas, A
Diaz, A
author_role author
author2 Broner, S
Izquierdo, C
Pallares, R
Munoz-Almagro, C
Hernandez, S
Grau, I
Dominguez, A
Jane, M
Esteva, C
de Sevilla, MF
Henares, D
Ardanuy, C
Marco, F
Margall, N
Gonzalez-Cuevas, A
Diaz, A
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Streptococcus pneumoniae
IPD
PCV13
Adults
Case fatality rate
Comorbidities
Mortality
topic Streptococcus pneumoniae
IPD
PCV13
Adults
Case fatality rate
Comorbidities
Mortality
description Objectives: The aim of this study was to assess the indirect effect of paediatric 13-valent pneumococcal conjugate vaccine (PCV13) vaccination on people >= 65 years of age with invasive pneumococcal disease (IPD) in Catalonia and to determine factors predictive of mortality. Methods: During 2014-2016, 1285 IPD cases were reported to the Public Health Agency of Catalonia. The indirect effect of paediatric PCV13 vaccination was calculated by comparing the incidence rate (IR) in 2016 (PCV13 year) with that in 2009 (pre-PCV13). Predictors of mortality were determined using multivariate logistic regression. Results: Comparing 2016 and 2009, IPD decreased by 19% (IR 40.1 and 32.5 per 100 000 person-years, respectively). PCV13 serotypes decreased by 57% (IR 23.7 and 10.1), while non-PCV13 serotypes increased by 36% (IR 16.4 and 22.4). During 2014-2016, the mortality rate was 17.5%, and mortality was associated with age >= 85 years (adjusted odds ratio (aOR) 2.91, 95% confidence interval (CI) 1.89, 4.48), meningitis (aOR 2.29, 95% CI 1.25, 4.19), non-focal bacteraemia (aOR 3.73, 95% CI 2.00, 6.94), and >= 1 high-risk condition (aOR 1.89, 95% CI 1.08, 3.32). PPV23non13 serotypes were associated with lower mortality than PCV13 serotypes (aOR 0.54, 95% CI 0.34, 0.86). Conclusions: The incidence of IPD in people >= 65 years of age decreased after the introduction of paediatric PCV13, and this was due to a reduction in PCV13 serotypes, although an increase in non-PCV13 serotypes was observed. Mortality was associated with age, meningitis, non-focal bacteraemia, >= 1 high-risk condition, and PCV13 serotypes. (C) 2019 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
publishDate 2019
dc.date.none.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13759
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=13759
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv ELSEVIER SCI LTD
publisher.none.fl_str_mv ELSEVIER SCI LTD
dc.source.none.fl_str_mv INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
ISSN: 12019712
ISSNe: 18783511
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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