Gene signatures in patients with early breast cancer and relapse despite pathologic complete response

Prognostic markers; Tumour biomarkers

Detalles Bibliográficos
Autores: Bruzas, Simona, Gluz, Oleg, Cortés Castan, Javier, Blohmer, Jens-Uwe, Schmid, Peter, Harbeck, Nadia
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/8003
Acceso en línea:https://hdl.handle.net/11351/8003
Access Level:acceso abierto
Palabra clave:Mama - Càncer - Aspectes genètics
Mama - Càncer - Recaiguda
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, Local
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
ENFERMEDADES::neoplasias::procesos neoplásicos::recurrencia neoplásica local
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network_acronym_str ES
network_name_str España
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spelling Gene signatures in patients with early breast cancer and relapse despite pathologic complete responseBruzas, SimonaGluz, OlegCortés Castan, JavierBlohmer, Jens-UweSchmid, PeterHarbeck, NadiaMama - Càncer - Aspectes genèticsMama - Càncer - RecaigudaDISEASES::Neoplasms::Neoplasms by Site::Breast NeoplasmsOther subheadings::Other subheadings::Other subheadings::/geneticsDISEASES::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, LocalENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mamaOtros calificadores::Otros calificadores::Otros calificadores::/genéticaENFERMEDADES::neoplasias::procesos neoplásicos::recurrencia neoplásica localPrognostic markers; Tumour biomarkersMarcadores pronósticos; Biomarcadores tumoralesMarcadors pronòstics; Biomarcadors tumoralsA substantial minority of early breast cancer (EBC) patients relapse despite their tumors achieving pathologic complete response (pCR) after neoadjuvant therapy. We compared gene expression (BC360; nCounter® platform; NanoString) between primary tumors of patients with post-pCR relapse (N = 14) with: (i) matched recurrent tumors from same patient (intraindividual analysis); and (ii) primary tumors from matched controls with pCR and no relapse (N = 41; interindividual analysis). Intraindividual analysis showed lower estrogen receptor signaling signature expression in recurrent tumors versus primaries (logFC = −0.595; P = 0.022). Recurrent tumors in patients with distant metastases also exhibited reduced expression of immune-related expression parameters. In interindividual analyses, primary tumor major histocompatibility complex class II expression was lower versus controls in patients with any relapse (logFC = −0.819; P = 0.030) or distant relapse (logFC = −1.151; P = 0.013). Primaries with later distant relapse also had greater homologous recombination deficiency than controls (logFC = 0.649; P = 0.026). Although no associations remained statistically significant following adjustment for false discovery rate, our results show that transcriptomic analyses have potential for prognostic value and may help in selecting optimal treatment regimens for EBC at risk of relapse and warrant further investigation.Springer NatureInstitut Català de la Salut[Bruzas S] Interdisciplinary Breast Unit, Kliniken Essen-Mitte, Essen, Germany. [Gluz O] West German Study Group, Moenchengladbach, Germany. Breast Center Niederrhein, Evangelical Hospital Bethesda, Moenchengladbach, Germany. [Harbeck N] Breast Center, Dept. OB&GYN and CCCLMU, University of Munich (LMU), Munich, Germany. [Schmid P] Barts Cancer Institute, Queen Mary University London, London, United Kingdom. [Cortés J] International Breast Cancer Centre (IBCC), Quiron Group, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain. Medica Scientia Innovation Research (MEDSIR), Ridgewood, NJ, USA. [Blohmer J] Klinik für Gynäkologie mit Brustzentrum, Charité-Universitätsmedizin Berlin, Berlin, GermanyVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/8003Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésNPJ Breast Cancer;8https://doi.org/10.1038/s41523-022-00403-3Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/80032026-06-12T09:38:37Z
dc.title.none.fl_str_mv Gene signatures in patients with early breast cancer and relapse despite pathologic complete response
title Gene signatures in patients with early breast cancer and relapse despite pathologic complete response
spellingShingle Gene signatures in patients with early breast cancer and relapse despite pathologic complete response
Bruzas, Simona
Mama - Càncer - Aspectes genètics
Mama - Càncer - Recaiguda
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, Local
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
ENFERMEDADES::neoplasias::procesos neoplásicos::recurrencia neoplásica local
title_short Gene signatures in patients with early breast cancer and relapse despite pathologic complete response
title_full Gene signatures in patients with early breast cancer and relapse despite pathologic complete response
title_fullStr Gene signatures in patients with early breast cancer and relapse despite pathologic complete response
title_full_unstemmed Gene signatures in patients with early breast cancer and relapse despite pathologic complete response
title_sort Gene signatures in patients with early breast cancer and relapse despite pathologic complete response
dc.creator.none.fl_str_mv Bruzas, Simona
Gluz, Oleg
Cortés Castan, Javier
Blohmer, Jens-Uwe
Schmid, Peter
Harbeck, Nadia
author Bruzas, Simona
author_facet Bruzas, Simona
Gluz, Oleg
Cortés Castan, Javier
Blohmer, Jens-Uwe
Schmid, Peter
Harbeck, Nadia
author_role author
author2 Gluz, Oleg
Cortés Castan, Javier
Blohmer, Jens-Uwe
Schmid, Peter
Harbeck, Nadia
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Bruzas S] Interdisciplinary Breast Unit, Kliniken Essen-Mitte, Essen, Germany. [Gluz O] West German Study Group, Moenchengladbach, Germany. Breast Center Niederrhein, Evangelical Hospital Bethesda, Moenchengladbach, Germany. [Harbeck N] Breast Center, Dept. OB&GYN and CCCLMU, University of Munich (LMU), Munich, Germany. [Schmid P] Barts Cancer Institute, Queen Mary University London, London, United Kingdom. [Cortés J] International Breast Cancer Centre (IBCC), Quiron Group, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Medica Scientia Innovation Research (MEDSIR), Barcelona, Spain. Medica Scientia Innovation Research (MEDSIR), Ridgewood, NJ, USA. [Blohmer J] Klinik für Gynäkologie mit Brustzentrum, Charité-Universitätsmedizin Berlin, Berlin, Germany
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Mama - Càncer - Aspectes genètics
Mama - Càncer - Recaiguda
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, Local
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
ENFERMEDADES::neoplasias::procesos neoplásicos::recurrencia neoplásica local
topic Mama - Càncer - Aspectes genètics
Mama - Càncer - Recaiguda
DISEASES::Neoplasms::Neoplasms by Site::Breast Neoplasms
Other subheadings::Other subheadings::Other subheadings::/genetics
DISEASES::Neoplasms::Neoplastic Processes::Neoplasm Recurrence, Local
ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias de la mama
Otros calificadores::Otros calificadores::Otros calificadores::/genética
ENFERMEDADES::neoplasias::procesos neoplásicos::recurrencia neoplásica local
description Prognostic markers; Tumour biomarkers
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/8003
url https://hdl.handle.net/11351/8003
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv NPJ Breast Cancer;8
https://doi.org/10.1038/s41523-022-00403-3
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Nature
publisher.none.fl_str_mv Springer Nature
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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