Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.

Congestion explains many of the signs and symptoms of acute heart failure (AHF) and disease progression. However, accurate quantification of congestion is challenging in daily practice. Antigen carbohydrate 125 (CA125) or mucin 16 (MUC16), a large glycoprotein synthesized by mesothelial cells, has e...

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Autores: Nunez, J, de la Espriella, R, Minana, G, Santas, E, Llacer, P, Nunez, E, Palau, P, Bodi, V, Chorro, FJ, Sanchis, J, Lupon, J, Bayes-Genis, A
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:INCLIVA
Repositorio:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:oai:incliva.fundanetsuite.com:p15850
Acceso en línea:https://incliva.portalinvestigacion.com/publicaciones/15850
Access Level:acceso abierto
Palabra clave:CA125
Heart failure
MUC16
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spelling Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.Nunez, Jde la Espriella, RMinana, GSantas, ELlacer, PNunez, EPalau, PBodi, VChorro, FJSanchis, JLupon, JBayes-Genis, ACA125Heart failureMUC16Congestion explains many of the signs and symptoms of acute heart failure (AHF) and disease progression. However, accurate quantification of congestion is challenging in daily practice. Antigen carbohydrate 125 (CA125) or mucin 16 (MUC16), a large glycoprotein synthesized by mesothelial cells, has emerged as a reliable proxy of congestion and inflammation in patients with heart failure (HF). In AHF syndromes, CA125 is strongly associated with right-sided HF parameters and a higher risk of adverse clinical events beyond standard prognostic factors, including natriuretic peptides. Furthermore, CA125 has the potential for both monitoring and guide HF treatment following a decompensated HF event. The wide availability of CA125 in most clinical laboratories, together with its standardized measurement and reduced cost, makes this marker attractive for routine use in decompensated HF. Further research is required to understand better its biological role and its promising utility as a tool to guide decongestive therapy in HF.WILEY2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/15850EUROPEAN JOURNAL OF HEART FAILUREISSN: 13889842ISSNe: 18790844reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p158502026-06-07T16:35:31Z
dc.title.none.fl_str_mv Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
title Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
spellingShingle Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
Nunez, J
CA125
Heart failure
MUC16
title_short Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
title_full Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
title_fullStr Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
title_full_unstemmed Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
title_sort Antigen carbohydrate 125 as a biomarker in heart failure: a narrative review.
dc.creator.none.fl_str_mv Nunez, J
de la Espriella, R
Minana, G
Santas, E
Llacer, P
Nunez, E
Palau, P
Bodi, V
Chorro, FJ
Sanchis, J
Lupon, J
Bayes-Genis, A
author Nunez, J
author_facet Nunez, J
de la Espriella, R
Minana, G
Santas, E
Llacer, P
Nunez, E
Palau, P
Bodi, V
Chorro, FJ
Sanchis, J
Lupon, J
Bayes-Genis, A
author_role author
author2 de la Espriella, R
Minana, G
Santas, E
Llacer, P
Nunez, E
Palau, P
Bodi, V
Chorro, FJ
Sanchis, J
Lupon, J
Bayes-Genis, A
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CA125
Heart failure
MUC16
topic CA125
Heart failure
MUC16
description Congestion explains many of the signs and symptoms of acute heart failure (AHF) and disease progression. However, accurate quantification of congestion is challenging in daily practice. Antigen carbohydrate 125 (CA125) or mucin 16 (MUC16), a large glycoprotein synthesized by mesothelial cells, has emerged as a reliable proxy of congestion and inflammation in patients with heart failure (HF). In AHF syndromes, CA125 is strongly associated with right-sided HF parameters and a higher risk of adverse clinical events beyond standard prognostic factors, including natriuretic peptides. Furthermore, CA125 has the potential for both monitoring and guide HF treatment following a decompensated HF event. The wide availability of CA125 in most clinical laboratories, together with its standardized measurement and reduced cost, makes this marker attractive for routine use in decompensated HF. Further research is required to understand better its biological role and its promising utility as a tool to guide decongestive therapy in HF.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://incliva.portalinvestigacion.com/publicaciones/15850
url https://incliva.portalinvestigacion.com/publicaciones/15850
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv WILEY
publisher.none.fl_str_mv WILEY
dc.source.none.fl_str_mv EUROPEAN JOURNAL OF HEART FAILURE
ISSN: 13889842
ISSNe: 18790844
reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
instname:INCLIVA
instname_str INCLIVA
reponame_str r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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