Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis
Background & Aims: Treatment with non-selective beta-blockers (NSBBs) reduces the risk of ascites, which is the most common decompensating event in cirrhosis. This study aimed to assess the ability of a serum microRNA (miRNA) signature to predict ascites formation and the hemodynamic response to...
| Autores: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:270216 |
| Acceso en línea: | https://ddd.uab.cat/record/270216 https://dx.doi.org/urn:doi:10.1016/j.jhepr.2021.100368 |
| Access Level: | acceso abierto |
| Palabra clave: | Ascites Beta-blockers Cirrhosis MicroRNA Portal hypertension |
| id |
ES_73a9d305ce514b5ed665115f4856958a |
|---|---|
| oai_identifier_str |
oai:ddd.uab.cat:270216 |
| network_acronym_str |
ES |
| network_name_str |
España |
| repository_id_str |
|
| spelling |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosisGarcia Garcia de Paredes, Ana|||0000-0001-5498-6280Villanueva, Càndid|||0000-0002-3674-914XBlanco, CarolinaGenescà Ferrer, Joan|||0000-0002-0831-8422Manicardi, NicoloGarcía-Pagán, JC.|||0000-0001-9032-4954Calleja, Jose Luis|||0000-0002-2265-6591Aracil, Carlos|||0000-0002-8228-9041Morillas Cunill, Rosa Ma|||0000-0001-9117-5049Poca Sans, Maria|||0000-0002-0235-1395Peñas, BeatrizAugustin Recio, Salvador|||0000-0002-3515-9033Abraldes, Juan G.|||0000-0003-3421-937XAlvarado-Tapias, Edilmar|||0000-0003-2036-6133Royo, FélixGarcía-Bermejo, Mª LauraFalcón-Pérez, Juan M.|||0000-0003-3133-0670Bañares, Rafael|||0000-0002-0412-8437Bosch, Jaime|||0000-0003-3414-0055Gracia-Sancho, Jordi|||0000-0001-7736-4089Albillos, Agustín|||0000-0001-9131-2592AscitesBeta-blockersCirrhosisMicroRNAPortal hypertensionBackground & Aims: Treatment with non-selective beta-blockers (NSBBs) reduces the risk of ascites, which is the most common decompensating event in cirrhosis. This study aimed to assess the ability of a serum microRNA (miRNA) signature to predict ascites formation and the hemodynamic response to NSBBs in compensated cirrhosis. Methods: Serum levels of miR-452-5p, miR-429, miR-885-5p, miR-181b-5p, and miR-122-5p were analyzed in patients with compensated cirrhosis (N = 105). Hepatic venous pressure gradient (HVPG) was measured at baseline, after intravenous propranolol, and 1 year after randomization to NSBBs (n = 52) or placebo (n = 53) (PREDESCI trial). miRNAs were analyzed at baseline and at 1 year. Results: Nineteen patients (18%) developed ascites, of whom 17 developed ascites after 1 year. miR-181b-5p levels at 1 year, but not at baseline, were higher in patients that developed ascites. The AUC of miR-181b-5p at 1 year to predict ascites was 0.7 (95% CI 0.59-0.78). miR-429 levels were lower at baseline in acute HVPG responders to NSBBs (AUC 0.65; 95% CI, 0.53-0.76), but levels at baseline and at 1 year were not associated with the HVPG response to NSBBs at 1 year. Conclusions: Serum miR-181b-5p is a promising non-invasive biomarker to identify patients with compensated cirrhosis at risk of ascites development. Lay summary: Ascites marks the transition from the compensated to decompensated stage in cirrhosis and indicates a worsening in prognosis. There are currently no easily accessible tools to identify patients with compensated cirrhosis at risk of developing ascites. We evaluated the levels of novel molecules termed microRNAs in the blood of patients with compensated cirrhosis and observed that miR-181b-5p can predict which patients are going to develop ascites.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/270216https://dx.doi.org/urn:doi:10.1016/j.jhepr.2021.100368reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 SAF2017-86343-RInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01302Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01901Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CIBEREHD-16PI03Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00220Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM18/00091open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2702162026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis |
| title |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis |
| spellingShingle |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis Garcia Garcia de Paredes, Ana|||0000-0001-5498-6280 Ascites Beta-blockers Cirrhosis MicroRNA Portal hypertension |
| title_short |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis |
| title_full |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis |
| title_fullStr |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis |
| title_full_unstemmed |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis |
| title_sort |
Serum miR-181b-5p predicts ascites onset in patients with compensated cirrhosis |
| dc.creator.none.fl_str_mv |
Garcia Garcia de Paredes, Ana|||0000-0001-5498-6280 Villanueva, Càndid|||0000-0002-3674-914X Blanco, Carolina Genescà Ferrer, Joan|||0000-0002-0831-8422 Manicardi, Nicolo García-Pagán, JC.|||0000-0001-9032-4954 Calleja, Jose Luis|||0000-0002-2265-6591 Aracil, Carlos|||0000-0002-8228-9041 Morillas Cunill, Rosa Ma|||0000-0001-9117-5049 Poca Sans, Maria|||0000-0002-0235-1395 Peñas, Beatriz Augustin Recio, Salvador|||0000-0002-3515-9033 Abraldes, Juan G.|||0000-0003-3421-937X Alvarado-Tapias, Edilmar|||0000-0003-2036-6133 Royo, Félix García-Bermejo, Mª Laura Falcón-Pérez, Juan M.|||0000-0003-3133-0670 Bañares, Rafael|||0000-0002-0412-8437 Bosch, Jaime|||0000-0003-3414-0055 Gracia-Sancho, Jordi|||0000-0001-7736-4089 Albillos, Agustín|||0000-0001-9131-2592 |
| author |
Garcia Garcia de Paredes, Ana|||0000-0001-5498-6280 |
| author_facet |
Garcia Garcia de Paredes, Ana|||0000-0001-5498-6280 Villanueva, Càndid|||0000-0002-3674-914X Blanco, Carolina Genescà Ferrer, Joan|||0000-0002-0831-8422 Manicardi, Nicolo García-Pagán, JC.|||0000-0001-9032-4954 Calleja, Jose Luis|||0000-0002-2265-6591 Aracil, Carlos|||0000-0002-8228-9041 Morillas Cunill, Rosa Ma|||0000-0001-9117-5049 Poca Sans, Maria|||0000-0002-0235-1395 Peñas, Beatriz Augustin Recio, Salvador|||0000-0002-3515-9033 Abraldes, Juan G.|||0000-0003-3421-937X Alvarado-Tapias, Edilmar|||0000-0003-2036-6133 Royo, Félix García-Bermejo, Mª Laura Falcón-Pérez, Juan M.|||0000-0003-3133-0670 Bañares, Rafael|||0000-0002-0412-8437 Bosch, Jaime|||0000-0003-3414-0055 Gracia-Sancho, Jordi|||0000-0001-7736-4089 Albillos, Agustín|||0000-0001-9131-2592 |
| author_role |
author |
| author2 |
Villanueva, Càndid|||0000-0002-3674-914X Blanco, Carolina Genescà Ferrer, Joan|||0000-0002-0831-8422 Manicardi, Nicolo García-Pagán, JC.|||0000-0001-9032-4954 Calleja, Jose Luis|||0000-0002-2265-6591 Aracil, Carlos|||0000-0002-8228-9041 Morillas Cunill, Rosa Ma|||0000-0001-9117-5049 Poca Sans, Maria|||0000-0002-0235-1395 Peñas, Beatriz Augustin Recio, Salvador|||0000-0002-3515-9033 Abraldes, Juan G.|||0000-0003-3421-937X Alvarado-Tapias, Edilmar|||0000-0003-2036-6133 Royo, Félix García-Bermejo, Mª Laura Falcón-Pérez, Juan M.|||0000-0003-3133-0670 Bañares, Rafael|||0000-0002-0412-8437 Bosch, Jaime|||0000-0003-3414-0055 Gracia-Sancho, Jordi|||0000-0001-7736-4089 Albillos, Agustín|||0000-0001-9131-2592 |
| author2_role |
author author author author author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Ascites Beta-blockers Cirrhosis MicroRNA Portal hypertension |
| topic |
Ascites Beta-blockers Cirrhosis MicroRNA Portal hypertension |
| description |
Background & Aims: Treatment with non-selective beta-blockers (NSBBs) reduces the risk of ascites, which is the most common decompensating event in cirrhosis. This study aimed to assess the ability of a serum microRNA (miRNA) signature to predict ascites formation and the hemodynamic response to NSBBs in compensated cirrhosis. Methods: Serum levels of miR-452-5p, miR-429, miR-885-5p, miR-181b-5p, and miR-122-5p were analyzed in patients with compensated cirrhosis (N = 105). Hepatic venous pressure gradient (HVPG) was measured at baseline, after intravenous propranolol, and 1 year after randomization to NSBBs (n = 52) or placebo (n = 53) (PREDESCI trial). miRNAs were analyzed at baseline and at 1 year. Results: Nineteen patients (18%) developed ascites, of whom 17 developed ascites after 1 year. miR-181b-5p levels at 1 year, but not at baseline, were higher in patients that developed ascites. The AUC of miR-181b-5p at 1 year to predict ascites was 0.7 (95% CI 0.59-0.78). miR-429 levels were lower at baseline in acute HVPG responders to NSBBs (AUC 0.65; 95% CI, 0.53-0.76), but levels at baseline and at 1 year were not associated with the HVPG response to NSBBs at 1 year. Conclusions: Serum miR-181b-5p is a promising non-invasive biomarker to identify patients with compensated cirrhosis at risk of ascites development. Lay summary: Ascites marks the transition from the compensated to decompensated stage in cirrhosis and indicates a worsening in prognosis. There are currently no easily accessible tools to identify patients with compensated cirrhosis at risk of developing ascites. We evaluated the levels of novel molecules termed microRNAs in the blood of patients with compensated cirrhosis and observed that miR-181b-5p can predict which patients are going to develop ascites. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/270216 https://dx.doi.org/urn:doi:10.1016/j.jhepr.2021.100368 |
| url |
https://ddd.uab.cat/record/270216 https://dx.doi.org/urn:doi:10.1016/j.jhepr.2021.100368 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 SAF2017-86343-R Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01302 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01901 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CIBEREHD-16PI03 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/00220 Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CM18/00091 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.source.none.fl_str_mv |
reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
| instname_str |
Universitat Autònoma de Barcelona |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| collection |
Dipòsit Digital de Documents de la UAB |
| repository.name.fl_str_mv |
|
| repository.mail.fl_str_mv |
|
| _version_ |
1869410826283122688 |
| score |
15,300719 |