The Epstein Barr-encoded BART-6-3p microRNA affects regulation of cell growth and immuno response in Burkitt lymphoma

[Background] Burkitt lymphoma is an aggressive B-cell lymphoma presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. More than 90% of endemic Burkitt lymphoma carry latent Epstein-Barr virus, whereas only 20% of sporadic Burkitt lymphoma are associated with Epstein-B...

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Detalles Bibliográficos
Autores: Ambrosio, Maria Raffaella, Navari, Mohsen, Lisio, Lorena di, Andrés-León, Eduardo, Onnis, Anna, Gazaneo, Sara, Mundo, Lucia, Ulivieri, Cristina, Gómez, Gonzalo, Lazzi, Stefano, Piris, M. A., Leoncini, Lorenzo, Falco, Giulia de
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2014
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/413009
Acceso en línea:http://hdl.handle.net/10261/413009
https://api.elsevier.com/content/abstract/scopus_id/84899931764
Access Level:acceso abierto
Palabra clave:Burkitt lymphoma
EBV
MicroRNAs
Descripción
Sumario:[Background] Burkitt lymphoma is an aggressive B-cell lymphoma presenting in three clinical forms: endemic, sporadic and immunodeficiency-associated. More than 90% of endemic Burkitt lymphoma carry latent Epstein-Barr virus, whereas only 20% of sporadic Burkitt lymphoma are associated with Epstein-Barr infection. Although the Epstein-Barr virus is highly related with the endemic form, how and whether the virus participates in its pathogenesis remains to be fully elucidated. In particular, the virus may impair cellular gene expression by its own encoded microRNAs.

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