Cause of Death in Heart Failure Based on Etiology

We assessed differences in long-term all-cause and cardiovascular (CV) mortality in heart failure (HF) outpatients based on the etiology of HF. Consecutive patients admitted to the HF Clinic from August 2001 to September 2019 (N = 2587) were considered for inclusion. HF etiology was divided into isc...

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Detalles Bibliográficos
Autores: Spitaleri, Giosafat|||0000-0002-0214-9082, Zamora, Elisabet|||0000-0001-5317-7481, Cediel, Germán|||0000-0001-9667-7507, Codina, Pau|||0000-0002-2469-5711, Santiago Vacas, Evelyn|||0000-0001-7511-406X, Domingo, Mar|||0000-0002-2935-1272, Lupón, Josep|||0000-0002-5601-9611, Santesmases, Javier|||0000-0002-1226-1617, Diez-Quevedo, Crisanto|||0000-0002-0705-295X, Troya, Maria Isabel, Boldo Alcaine, Maria, Altimir Losada, Salvador, Alonso Pedrol, Núria|||0000-0001-9687-8050, González Fernández, Beatriz|||0000-0002-3699-9392, Bayés-Genís, Antoni|||0000-0002-3044-197X
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256046
Acceso en línea:https://ddd.uab.cat/record/256046
https://dx.doi.org/urn:doi:10.3390/jcm11030784
Access Level:acceso abierto
Palabra clave:Heart failure with reduced ejection fraction
Heart failure with preserved ejection fraction
Heart failure etiology
Descripción
Sumario:We assessed differences in long-term all-cause and cardiovascular (CV) mortality in heart failure (HF) outpatients based on the etiology of HF. Consecutive patients admitted to the HF Clinic from August 2001 to September 2019 (N = 2587) were considered for inclusion. HF etiology was divided into ischemic heart disease (IHD), dilated cardiomyopathy (DCM), hypertensive heart disease, alcoholic cardiomyopathy, drug-induced cardiomyopathy (DICM), valvular heart disease, and hypertrophic cardiomyopathy. All-cause death and CV death were the primary end points. Among 2387 patients included in the analysis (mean age 66.5 ± 12.5 years, 71.3% men), 1317 deaths were recorded (731 from CV cause) over a maximum follow-up of 18 years (median 4.1 years, interquartile range (IQR) 2-7.8). Considering IHD as the reference, only DCM had a lower risk of all-cause death (adjusted hazard ratio (aHR) 0.68, 95% confidence interval (CI) 0.56-0.83, p < 0.001), and only DICM had a higher risk of all-cause death (aHR 1.47, 95% CI 1.02-2.11, p = 0.04). However, almost all etiologies had a significantly lower risk of CV death than IHD. Among the studied HF etiologies, DCM and DICM have the lowest and highest risk of all-cause death, respectively, whereas IHD has the highest adjusted risk of CV death.

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