Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs

The inclusion of health-related traits, or functionally associated genetic markers, in pig breeding programs could contribute to produce more robust and disease resistant animals. The aim of the present work was to study the genetic determinism and genomic regions associated to global immunocompeten...

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Autores: Ballester Devis, Maria|||0000-0002-5413-4640, Ramayo-Caldas, Yuliaxis|||0000-0002-8142-0159, González-Rodríguez, Olga, Pascual, Mariam|||0000-0002-7233-2632, Reixach, Josep|||0000-0003-0669-7593, Díaz, Marta, Blanc, Fany, López-Serrano, Sergi|||0000-0002-0968-7713, Tibau, Joan|||0000-0001-5059-0545, Quintanilla, Raquel|||0000-0003-3274-3434
Formato: artículo
Fecha de publicación:2020
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:253032
Acesso em linha:https://ddd.uab.cat/record/253032
https://dx.doi.org/urn:doi:10.1038/s41598-020-75417-7
Access Level:acceso abierto
Palavra-chave:Genetics
Animal breeding
Genetic association study
Genetic markers
Immunogenetics
Quantitative trait
Immunology
Innate immunity
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spelling Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigsBallester Devis, Maria|||0000-0002-5413-4640Ramayo-Caldas, Yuliaxis|||0000-0002-8142-0159González-Rodríguez, OlgaPascual, Mariam|||0000-0002-7233-2632Reixach, Josep|||0000-0003-0669-7593Díaz, MartaBlanc, FanyLópez-Serrano, Sergi|||0000-0002-0968-7713Tibau, Joan|||0000-0001-5059-0545Quintanilla, Raquel|||0000-0003-3274-3434GeneticsAnimal breedingGenetic association studyGenetic markersImmunogeneticsQuantitative traitImmunologyInnate immunityThe inclusion of health-related traits, or functionally associated genetic markers, in pig breeding programs could contribute to produce more robust and disease resistant animals. The aim of the present work was to study the genetic determinism and genomic regions associated to global immunocompetence and health in a Duroc pig population. For this purpose, a set of 30 health-related traits covering immune (mainly innate), haematological, and stress parameters were measured in 432 healthy Duroc piglets aged 8 weeks. Moderate to high heritabilities were obtained for most traits and significant genetic correlations among them were observed. A genome wide association study pointed out 31 significantly associated SNPs at whole-genome level, located in six chromosomal regions on pig chromosomes SSC4, SSC6, SSC17 and SSCX, for IgG, γδ T-cells, C-reactive protein, lymphocytes phagocytic capacity, total number of lymphocytes, mean corpuscular volume and mean corpuscular haemoglobin. A total of 16 promising functionally-related candidate genes, including CRP, NFATC2, PRDX1, SLA, ST3GAL1, and VPS4A, have been proposed to explain the variation of immune and haematological traits. Our results enhance the knowledge of the genetic control of traits related with immunity and support the possibility of applying effective selection programs to improve immunocompetence in pigs. 22020-01-0120202020-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/253032https://dx.doi.org/urn:doi:10.1038/s41598-020-75417-7reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-75432-RMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 RYC-2013-12573Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1719open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2530322026-06-06T12:50:31Z
dc.title.none.fl_str_mv Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs
title Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs
spellingShingle Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs
Ballester Devis, Maria|||0000-0002-5413-4640
Genetics
Animal breeding
Genetic association study
Genetic markers
Immunogenetics
Quantitative trait
Immunology
Innate immunity
title_short Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs
title_full Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs
title_fullStr Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs
title_full_unstemmed Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs
title_sort Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs
dc.creator.none.fl_str_mv Ballester Devis, Maria|||0000-0002-5413-4640
Ramayo-Caldas, Yuliaxis|||0000-0002-8142-0159
González-Rodríguez, Olga
Pascual, Mariam|||0000-0002-7233-2632
Reixach, Josep|||0000-0003-0669-7593
Díaz, Marta
Blanc, Fany
López-Serrano, Sergi|||0000-0002-0968-7713
Tibau, Joan|||0000-0001-5059-0545
Quintanilla, Raquel|||0000-0003-3274-3434
author Ballester Devis, Maria|||0000-0002-5413-4640
author_facet Ballester Devis, Maria|||0000-0002-5413-4640
Ramayo-Caldas, Yuliaxis|||0000-0002-8142-0159
González-Rodríguez, Olga
Pascual, Mariam|||0000-0002-7233-2632
Reixach, Josep|||0000-0003-0669-7593
Díaz, Marta
Blanc, Fany
López-Serrano, Sergi|||0000-0002-0968-7713
Tibau, Joan|||0000-0001-5059-0545
Quintanilla, Raquel|||0000-0003-3274-3434
author_role author
author2 Ramayo-Caldas, Yuliaxis|||0000-0002-8142-0159
González-Rodríguez, Olga
Pascual, Mariam|||0000-0002-7233-2632
Reixach, Josep|||0000-0003-0669-7593
Díaz, Marta
Blanc, Fany
López-Serrano, Sergi|||0000-0002-0968-7713
Tibau, Joan|||0000-0001-5059-0545
Quintanilla, Raquel|||0000-0003-3274-3434
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Genetics
Animal breeding
Genetic association study
Genetic markers
Immunogenetics
Quantitative trait
Immunology
Innate immunity
topic Genetics
Animal breeding
Genetic association study
Genetic markers
Immunogenetics
Quantitative trait
Immunology
Innate immunity
description The inclusion of health-related traits, or functionally associated genetic markers, in pig breeding programs could contribute to produce more robust and disease resistant animals. The aim of the present work was to study the genetic determinism and genomic regions associated to global immunocompetence and health in a Duroc pig population. For this purpose, a set of 30 health-related traits covering immune (mainly innate), haematological, and stress parameters were measured in 432 healthy Duroc piglets aged 8 weeks. Moderate to high heritabilities were obtained for most traits and significant genetic correlations among them were observed. A genome wide association study pointed out 31 significantly associated SNPs at whole-genome level, located in six chromosomal regions on pig chromosomes SSC4, SSC6, SSC17 and SSCX, for IgG, γδ T-cells, C-reactive protein, lymphocytes phagocytic capacity, total number of lymphocytes, mean corpuscular volume and mean corpuscular haemoglobin. A total of 16 promising functionally-related candidate genes, including CRP, NFATC2, PRDX1, SLA, ST3GAL1, and VPS4A, have been proposed to explain the variation of immune and haematological traits. Our results enhance the knowledge of the genetic control of traits related with immunity and support the possibility of applying effective selection programs to improve immunocompetence in pigs.
publishDate 2020
dc.date.none.fl_str_mv 2
2020-01-01
2020
2020-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/253032
https://dx.doi.org/urn:doi:10.1038/s41598-020-75417-7
url https://ddd.uab.cat/record/253032
https://dx.doi.org/urn:doi:10.1038/s41598-020-75417-7
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 AGL2016-75432-R
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RYC-2013-12573
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-1719
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.301603

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