Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain

Introduction: There are no data on the incidence of hypoxic-ischaemic encephalopathy (HIE) and the implementation of therapeutic hypothermia (TH) in Spain. Methods: This is a cross-sectional, national study, performed using an on-line questionnaire targeting level III neonatal care units in Spain. P...

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Autores: Arnaez J, García-Alix A, Arca G, Valverde E, Caserío S, Moral MT, Benavente-Fernández I, Lubián-López S, Grupo de Trabajo EHI-ESP
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p12826
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12826
Access Level:acceso abierto
Palabra clave:Hypoxia-ischaemia
Asphyxia
Newborn
Incidence
Induced hypothermia
Spain
Death
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spelling Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in SpainArnaez JGarcía-Alix AArca GValverde ECaserío SMoral MTBenavente-Fernández ILubián-López SGrupo de Trabajo EHI-ESPHypoxia-ischaemiaAsphyxiaNewbornIncidenceInduced hypothermiaSpainDeathIntroduction: There are no data on the incidence of hypoxic-ischaemic encephalopathy (HIE) and the implementation of therapeutic hypothermia (TH) in Spain. Methods: This is a cross-sectional, national study, performed using an on-line questionnaire targeting level III neonatal care units in Spain. Participants were requested to provide data of all newborns = 35 weeks of gestational age diagnosed with moderate-severe HIE over a two year-period (2012-2013), and of the implementation of TH up to June 2015. Results: All (90) contacted hospitals participated. HIE incidence rate was 0.77/1000 live newborns (95% CI 0.72 - 0.83). During 2012-2013, 86% of the newborns diagnosed with moderate-severe HIE received TH (active or passive). Active TH was increasingly used, from 78% in 2012 to 85% in 2013 (P=.01). Of the 14% that did not receive TH, it was mainly due to a delay in the diagnosis or inter-hospital transfer, and to the fact that the treatment was not offered. More than half (57%) were born in hospitals where TH was not provided, and passive hypothermia was used for inter-hospital patient transfer, and in 39% of the cases by inappropriately trained personnel. By June 2015, 57 out of 90 centres had implemented TH, of which 54 performed whole-body TH (using servo-controlled devices). The geographical distribution of centres with active TH, and the number of newborn that received TH, was heterogeneous. Conclusions: The incidence of moderate-severe HIE is homogeneous across Spanish territory. Significant progress is being made in the implementation of TH, however it is necessary to increase the availability of active TH between Autonomous Communities, to improve early diagnosis, and to guarantee high quality patient transfer to referral centres. (C) 2017 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.EDICIONES DOYMA S A2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12826ANALES DE PEDIATRIAISSN: 16954033ISSNe: 16959531reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuEspañolinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p128262026-05-27T12:37:41Z
dc.title.none.fl_str_mv Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain
title Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain
spellingShingle Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain
Arnaez J
Hypoxia-ischaemia
Asphyxia
Newborn
Incidence
Induced hypothermia
Spain
Death
title_short Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain
title_full Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain
title_fullStr Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain
title_full_unstemmed Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain
title_sort Incidence of hypoxic-ischaemic encephalopathy and use of therapeutic hypothermia in Spain
dc.creator.none.fl_str_mv Arnaez J
García-Alix A
Arca G
Valverde E
Caserío S
Moral MT
Benavente-Fernández I
Lubián-López S
Grupo de Trabajo EHI-ESP
author Arnaez J
author_facet Arnaez J
García-Alix A
Arca G
Valverde E
Caserío S
Moral MT
Benavente-Fernández I
Lubián-López S
Grupo de Trabajo EHI-ESP
author_role author
author2 García-Alix A
Arca G
Valverde E
Caserío S
Moral MT
Benavente-Fernández I
Lubián-López S
Grupo de Trabajo EHI-ESP
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hypoxia-ischaemia
Asphyxia
Newborn
Incidence
Induced hypothermia
Spain
Death
topic Hypoxia-ischaemia
Asphyxia
Newborn
Incidence
Induced hypothermia
Spain
Death
description Introduction: There are no data on the incidence of hypoxic-ischaemic encephalopathy (HIE) and the implementation of therapeutic hypothermia (TH) in Spain. Methods: This is a cross-sectional, national study, performed using an on-line questionnaire targeting level III neonatal care units in Spain. Participants were requested to provide data of all newborns = 35 weeks of gestational age diagnosed with moderate-severe HIE over a two year-period (2012-2013), and of the implementation of TH up to June 2015. Results: All (90) contacted hospitals participated. HIE incidence rate was 0.77/1000 live newborns (95% CI 0.72 - 0.83). During 2012-2013, 86% of the newborns diagnosed with moderate-severe HIE received TH (active or passive). Active TH was increasingly used, from 78% in 2012 to 85% in 2013 (P=.01). Of the 14% that did not receive TH, it was mainly due to a delay in the diagnosis or inter-hospital transfer, and to the fact that the treatment was not offered. More than half (57%) were born in hospitals where TH was not provided, and passive hypothermia was used for inter-hospital patient transfer, and in 39% of the cases by inappropriately trained personnel. By June 2015, 57 out of 90 centres had implemented TH, of which 54 performed whole-body TH (using servo-controlled devices). The geographical distribution of centres with active TH, and the number of newborn that received TH, was heterogeneous. Conclusions: The incidence of moderate-severe HIE is homogeneous across Spanish territory. Significant progress is being made in the implementation of TH, however it is necessary to increase the availability of active TH between Autonomous Communities, to improve early diagnosis, and to guarantee high quality patient transfer to referral centres. (C) 2017 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12826
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=12826
dc.language.none.fl_str_mv Español
language_invalid_str_mv Español
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv EDICIONES DOYMA S A
publisher.none.fl_str_mv EDICIONES DOYMA S A
dc.source.none.fl_str_mv ANALES DE PEDIATRIA
ISSN: 16954033
ISSNe: 16959531
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,198674

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