Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit

Outstanding progress has been achieved in developing therapeutic options for reasonably alleviating symptoms and prolonging the lifespan of patients suffering from myocardial infarction (MI). Current treatments, however, only partially address the functional recovery of post-infarcted myocardium, wh...

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Autores: Muñoz-Domínguez, Noelia, Roura, Santiago|||0000-0003-4063-9661, Prat-Vidal, Cristina|||0000-0002-5621-1101, Vives Armengol, Joaquim|||0000-0001-9719-5235
Formato: artículo
Fecha de publicación:2021
País:España
Recursos:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:251553
Acesso em linha:https://ddd.uab.cat/record/251553
https://dx.doi.org/urn:doi:10.3390/pharmaceutics13091336
Access Level:acceso abierto
Palavra-chave:Biomanufacturing
Cardiac tissue engineering
Clinical translation
Extracellular vesicles
Mesenchymal stromal cells
Myocardial infarction
Wharton's jelly
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spelling Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkitan experienced viewMuñoz-Domínguez, NoeliaRoura, Santiago|||0000-0003-4063-9661Prat-Vidal, Cristina|||0000-0002-5621-1101Vives Armengol, Joaquim|||0000-0001-9719-5235BiomanufacturingCardiac tissue engineeringClinical translationExtracellular vesiclesMesenchymal stromal cellsMyocardial infarctionWharton's jellyOutstanding progress has been achieved in developing therapeutic options for reasonably alleviating symptoms and prolonging the lifespan of patients suffering from myocardial infarction (MI). Current treatments, however, only partially address the functional recovery of post-infarcted myocardium, which is in fact the major goal for effective primary care. In this context, we largely investigated novel cell and TE tissue engineering therapeutic approaches for cardiac repair, particu-larly using multipotent mesenchymal stromal cells (MSC) and natural extracellular matrices, from pre-clinical studies to clinical application. A further step in this field is offered by MSC-derived extracellular vesicles (EV), which are naturally released nanosized lipid bilayer-delimited particles with a key role in cell-to-cell communication. Herein, in this review, we further describe and discuss the rationale, outcomes and challenges of our evidence-based therapy approaches using Wharton's jelly MSC and derived EV in post-MI management.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/251553https://dx.doi.org/urn:doi:10.3390/pharmaceutics13091336reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00256Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01227Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01788Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01487Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PIC18/00014Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI19/00039Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI20/00135Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-110137RB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-84324-C2-1-RAgència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-483Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-719Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2019PROD00122open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2515532026-06-06T12:50:31Z
dc.title.none.fl_str_mv Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit
an experienced view
title Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit
spellingShingle Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit
Muñoz-Domínguez, Noelia
Biomanufacturing
Cardiac tissue engineering
Clinical translation
Extracellular vesicles
Mesenchymal stromal cells
Myocardial infarction
Wharton's jelly
title_short Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit
title_full Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit
title_fullStr Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit
title_full_unstemmed Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit
title_sort Wharton's jelly mesenchymal stromal cells and derived extracellular vesicles as post-myocardial infarction therapeutic toolkit
dc.creator.none.fl_str_mv Muñoz-Domínguez, Noelia
Roura, Santiago|||0000-0003-4063-9661
Prat-Vidal, Cristina|||0000-0002-5621-1101
Vives Armengol, Joaquim|||0000-0001-9719-5235
author Muñoz-Domínguez, Noelia
author_facet Muñoz-Domínguez, Noelia
Roura, Santiago|||0000-0003-4063-9661
Prat-Vidal, Cristina|||0000-0002-5621-1101
Vives Armengol, Joaquim|||0000-0001-9719-5235
author_role author
author2 Roura, Santiago|||0000-0003-4063-9661
Prat-Vidal, Cristina|||0000-0002-5621-1101
Vives Armengol, Joaquim|||0000-0001-9719-5235
author2_role author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Biomanufacturing
Cardiac tissue engineering
Clinical translation
Extracellular vesicles
Mesenchymal stromal cells
Myocardial infarction
Wharton's jelly
topic Biomanufacturing
Cardiac tissue engineering
Clinical translation
Extracellular vesicles
Mesenchymal stromal cells
Myocardial infarction
Wharton's jelly
description Outstanding progress has been achieved in developing therapeutic options for reasonably alleviating symptoms and prolonging the lifespan of patients suffering from myocardial infarction (MI). Current treatments, however, only partially address the functional recovery of post-infarcted myocardium, which is in fact the major goal for effective primary care. In this context, we largely investigated novel cell and TE tissue engineering therapeutic approaches for cardiac repair, particu-larly using multipotent mesenchymal stromal cells (MSC) and natural extracellular matrices, from pre-clinical studies to clinical application. A further step in this field is offered by MSC-derived extracellular vesicles (EV), which are naturally released nanosized lipid bilayer-delimited particles with a key role in cell-to-cell communication. Herein, in this review, we further describe and discuss the rationale, outcomes and challenges of our evidence-based therapy approaches using Wharton's jelly MSC and derived EV in post-MI management.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/251553
https://dx.doi.org/urn:doi:10.3390/pharmaceutics13091336
url https://ddd.uab.cat/record/251553
https://dx.doi.org/urn:doi:10.3390/pharmaceutics13091336
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/00256
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI18/01227
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI19/01788
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01487
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PIC18/00014
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI19/00039
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 ICI20/00135
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-110137RB-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-84324-C2-1-R
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-483
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2017/SGR-719
Agència de Gestió d'Ajuts Universitaris i de Recerca https://doi.org/10.13039/501100003030 2019PROD00122
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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