Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8

Background and importance A higher incidence of venous thromboembolism [both pulmonary embolism and deep vein thrombosis (DVT)] in patients with coronavirus disease 2019 (COVID-19) has been described. But little is known about the true frequency of DVT in patients who attend emergency department (ED...

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Autores: Jimenez, S, Miro, O, Llorens, P, Martin-Sanchez, FJ, Burillo-Putze, G, Pinera, P, Martin, A, Alquezar, A, Garcia-Lamberechts, EJ, Jacob, J, Grima, MLL, Millan, J, Molina, F, Albero, PB, Cardozo, C, Modol, JM, Aguirre, A, Gaya, R, Adroher, M, Llauger, L, Diaz, JJL, Gonzalez, NC, Aragues, PL, Gomez, AP, del Castillo, JG, Behalf Spanish Investigators Emerg
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2021
País:España
Recursos:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositório:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:oai:iibsantpau.fundanetsuite.com:p4654
Acesso em linha:https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4654
http://hdl.handle.net/2445/177788
Access Level:Acceso aberto
Palavra-chave:clinical characteristics
coronavirus disease 2019
deep venous thrombosis
incidence
outcome
risk factors
severe acute respiratory syndrome coronavirus 2
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spelling Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8Jimenez, SMiro, OLlorens, PMartin-Sanchez, FJBurillo-Putze, GPinera, PMartin, AAlquezar, AGarcia-Lamberechts, EJJacob, JGrima, MLLMillan, JMolina, FAlbero, PBCardozo, CModol, JMAguirre, AGaya, RAdroher, MLlauger, LDiaz, JJLGonzalez, NCAragues, PLGomez, APdel Castillo, JGBehalf Spanish Investigators Emergclinical characteristicscoronavirus disease 2019deep venous thrombosisincidenceoutcomerisk factorssevere acute respiratory syndrome coronavirus 2Background and importance A higher incidence of venous thromboembolism [both pulmonary embolism and deep vein thrombosis (DVT)] in patients with coronavirus disease 2019 (COVID-19) has been described. But little is known about the true frequency of DVT in patients who attend emergency department (ED) and are diagnosed with COVID-19. Objective We investigated the incidence, risk factors, clinical characteristics and outcomes of DVT in patients with COVID-19 attending the ED before hospitalization. Methods We retrospectively reviewed all COVID patients diagnosed with DVT in 62 Spanish EDs (20% of Spanish EDs, case group) during the first 2 months of the COVID-19 outbreak. We compared DVT-COVID-19 patients with COVID-19 without DVT patients (control group). Relative frequencies of DVT were estimated in COVID and non-COVID patients visiting the ED and annual standardized incidences were estimated for both populations. Sixty-three patient characteristics and four outcomes were compared between cases and controls. Results We identified 112 DVT in 74 814 patients with COVID-19 attending the ED [1.50 parts per thousand; 95% confidence interval (CI), 1.23-1.80 parts per thousand]. This relative frequency was similar than that observed in non-COVID patients [2109/1 388 879; 1.52 parts per thousand; 95% CI, 1.45-1.69 parts per thousand; odds ratio (OR) = 0.98 [0.82-1.19]. Standardized incidence of DVT was higher in COVID patients (98,38 versus 42,93/100,000/year; OR, 2.20; 95% CI, 2.03-2.38). In COVID patients, the clinical characteristics associated with a higher risk of presenting DVT were older age and having a history of venous thromboembolism, recent surgery/immobilization and hypertension; chest pain and desaturation at ED arrival and some analytical disturbances were also more frequently seen, d-dimer >5000 ng/mL being the strongest. After adjustment for age and sex, hospitalization, ICU admission and prolonged hospitalization were more frequent in cases than controls, whereas mortality was similar (OR, 1.37; 95% CI, 0.77-2.45). Conclusions DVT was an unusual form of COVID presentation in COVID patients but was associated with a worse prognosis.LIPPINCOTT WILLIAMS & WILKINS2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4654http://hdl.handle.net/2445/177788European Journal of Emergency MedicineISSN: 09699546ISSNe: 14735695reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p46542026-06-14T12:41:47Z
dc.title.none.fl_str_mv Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8
title Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8
spellingShingle Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8
Jimenez, S
clinical characteristics
coronavirus disease 2019
deep venous thrombosis
incidence
outcome
risk factors
severe acute respiratory syndrome coronavirus 2
title_short Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8
title_full Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8
title_fullStr Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8
title_full_unstemmed Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8
title_sort Incidence, risk factors, clinical characteristics and outcomes of deep venous thrombosis in patients with COVID-19 attending the Emergency Department: results of the UMC-19-S-8
dc.creator.none.fl_str_mv Jimenez, S
Miro, O
Llorens, P
Martin-Sanchez, FJ
Burillo-Putze, G
Pinera, P
Martin, A
Alquezar, A
Garcia-Lamberechts, EJ
Jacob, J
Grima, MLL
Millan, J
Molina, F
Albero, PB
Cardozo, C
Modol, JM
Aguirre, A
Gaya, R
Adroher, M
Llauger, L
Diaz, JJL
Gonzalez, NC
Aragues, PL
Gomez, AP
del Castillo, JG
Behalf Spanish Investigators Emerg
author Jimenez, S
author_facet Jimenez, S
Miro, O
Llorens, P
Martin-Sanchez, FJ
Burillo-Putze, G
Pinera, P
Martin, A
Alquezar, A
Garcia-Lamberechts, EJ
Jacob, J
Grima, MLL
Millan, J
Molina, F
Albero, PB
Cardozo, C
Modol, JM
Aguirre, A
Gaya, R
Adroher, M
Llauger, L
Diaz, JJL
Gonzalez, NC
Aragues, PL
Gomez, AP
del Castillo, JG
Behalf Spanish Investigators Emerg
author_role author
author2 Miro, O
Llorens, P
Martin-Sanchez, FJ
Burillo-Putze, G
Pinera, P
Martin, A
Alquezar, A
Garcia-Lamberechts, EJ
Jacob, J
Grima, MLL
Millan, J
Molina, F
Albero, PB
Cardozo, C
Modol, JM
Aguirre, A
Gaya, R
Adroher, M
Llauger, L
Diaz, JJL
Gonzalez, NC
Aragues, PL
Gomez, AP
del Castillo, JG
Behalf Spanish Investigators Emerg
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv clinical characteristics
coronavirus disease 2019
deep venous thrombosis
incidence
outcome
risk factors
severe acute respiratory syndrome coronavirus 2
topic clinical characteristics
coronavirus disease 2019
deep venous thrombosis
incidence
outcome
risk factors
severe acute respiratory syndrome coronavirus 2
description Background and importance A higher incidence of venous thromboembolism [both pulmonary embolism and deep vein thrombosis (DVT)] in patients with coronavirus disease 2019 (COVID-19) has been described. But little is known about the true frequency of DVT in patients who attend emergency department (ED) and are diagnosed with COVID-19. Objective We investigated the incidence, risk factors, clinical characteristics and outcomes of DVT in patients with COVID-19 attending the ED before hospitalization. Methods We retrospectively reviewed all COVID patients diagnosed with DVT in 62 Spanish EDs (20% of Spanish EDs, case group) during the first 2 months of the COVID-19 outbreak. We compared DVT-COVID-19 patients with COVID-19 without DVT patients (control group). Relative frequencies of DVT were estimated in COVID and non-COVID patients visiting the ED and annual standardized incidences were estimated for both populations. Sixty-three patient characteristics and four outcomes were compared between cases and controls. Results We identified 112 DVT in 74 814 patients with COVID-19 attending the ED [1.50 parts per thousand; 95% confidence interval (CI), 1.23-1.80 parts per thousand]. This relative frequency was similar than that observed in non-COVID patients [2109/1 388 879; 1.52 parts per thousand; 95% CI, 1.45-1.69 parts per thousand; odds ratio (OR) = 0.98 [0.82-1.19]. Standardized incidence of DVT was higher in COVID patients (98,38 versus 42,93/100,000/year; OR, 2.20; 95% CI, 2.03-2.38). In COVID patients, the clinical characteristics associated with a higher risk of presenting DVT were older age and having a history of venous thromboembolism, recent surgery/immobilization and hypertension; chest pain and desaturation at ED arrival and some analytical disturbances were also more frequently seen, d-dimer >5000 ng/mL being the strongest. After adjustment for age and sex, hospitalization, ICU admission and prolonged hospitalization were more frequent in cases than controls, whereas mortality was similar (OR, 1.37; 95% CI, 0.77-2.45). Conclusions DVT was an unusual form of COVID presentation in COVID patients but was associated with a worse prognosis.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4654
http://hdl.handle.net/2445/177788
url https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=4654
http://hdl.handle.net/2445/177788
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv LIPPINCOTT WILLIAMS & WILKINS
publisher.none.fl_str_mv LIPPINCOTT WILLIAMS & WILKINS
dc.source.none.fl_str_mv European Journal of Emergency Medicine
ISSN: 09699546
ISSNe: 14735695
reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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