Substituted hydroxyapatite coatings of bone implants

Surface modification of orthopedic and dental implants has been demonstrated to be an effective strategy to accelerate bone healing at early implantation times. Among the different alternatives, coating implants with a layer of hydroxyapatite (HAp) is one of the most used techniques, due to its exce...

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Detalles Bibliográficos
Autores: Arcos Navarrete, Daniel, Vallet Regí, María Dulce Nombre
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/6048
Acceso en línea:https://hdl.handle.net/20.500.14352/6048
Access Level:acceso abierto
Palabra clave:546
615.46
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
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spelling Substituted hydroxyapatite coatings of bone implantsArcos Navarrete, DanielVallet Regí, María Dulce Nombre546615.46MaterialesQuímica inorgánica (Farmacia)3312 Tecnología de MaterialesSurface modification of orthopedic and dental implants has been demonstrated to be an effective strategy to accelerate bone healing at early implantation times. Among the different alternatives, coating implants with a layer of hydroxyapatite (HAp) is one of the most used techniques, due to its excellent biocompatibility and osteoconductive behavior. The composition and crystalline structure of HAp allow for numerous ionic substitutions that provide added value, such as antibiotic properties or osteoinduction. In this article, we will review and critically analyze the most important advances in the field of substituted hydroxyapatite coatings. In recent years substituted HAp coatings have been deposited not only on orthopedic prostheses and dental implants, but also on macroporous scaffolds, thus expanding their applications towards bone regeneration therapies. Besides, the capability of Q4 substituted HAps to immobilize proteins and growth factors by non-covalent interactions has opened new possibilities for preparing hybrid coatings that foster bone healing processes. Finally, the most important in vivo outcomes will be discussed to understand the perspectives of substituted HAp Q5 coatings from a clinical point of view.Royal Society of ChemistryUniversidad Complutense de Madrid20202020-02-1720202020-02-17journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/6048reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/60482026-06-02T12:44:21Z
dc.title.none.fl_str_mv Substituted hydroxyapatite coatings of bone implants
title Substituted hydroxyapatite coatings of bone implants
spellingShingle Substituted hydroxyapatite coatings of bone implants
Arcos Navarrete, Daniel
546
615.46
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
title_short Substituted hydroxyapatite coatings of bone implants
title_full Substituted hydroxyapatite coatings of bone implants
title_fullStr Substituted hydroxyapatite coatings of bone implants
title_full_unstemmed Substituted hydroxyapatite coatings of bone implants
title_sort Substituted hydroxyapatite coatings of bone implants
dc.creator.none.fl_str_mv Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
author Arcos Navarrete, Daniel
author_facet Arcos Navarrete, Daniel
Vallet Regí, María Dulce Nombre
author_role author
author2 Vallet Regí, María Dulce Nombre
author2_role author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 546
615.46
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
topic 546
615.46
Materiales
Química inorgánica (Farmacia)
3312 Tecnología de Materiales
description Surface modification of orthopedic and dental implants has been demonstrated to be an effective strategy to accelerate bone healing at early implantation times. Among the different alternatives, coating implants with a layer of hydroxyapatite (HAp) is one of the most used techniques, due to its excellent biocompatibility and osteoconductive behavior. The composition and crystalline structure of HAp allow for numerous ionic substitutions that provide added value, such as antibiotic properties or osteoinduction. In this article, we will review and critically analyze the most important advances in the field of substituted hydroxyapatite coatings. In recent years substituted HAp coatings have been deposited not only on orthopedic prostheses and dental implants, but also on macroporous scaffolds, thus expanding their applications towards bone regeneration therapies. Besides, the capability of Q4 substituted HAps to immobilize proteins and growth factors by non-covalent interactions has opened new possibilities for preparing hybrid coatings that foster bone healing processes. Finally, the most important in vivo outcomes will be discussed to understand the perspectives of substituted HAp Q5 coatings from a clinical point of view.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-02-17
2020
2020-02-17
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/6048
url https://hdl.handle.net/20.500.14352/6048
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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