Adipose-Derived Stem Cells to Treat Ischemic Diseases

Critical limb ischemia incidence and prevalence have increased over the years. However, there are no successful treatments to improve quality of life and to reduce the risk of cardiovascular and limb events in these patients. Advanced regenerative therapies have focused their interest on the generat...

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Autores: Arderiu, Gemma|||0000-0001-8598-4106, Civit-Urgell, Anna|||0000-0002-5804-8408, Badimon, Lina|||0000-0002-9162-2459
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:296599
Acceso en línea:https://ddd.uab.cat/record/296599
https://dx.doi.org/urn:doi:10.3390/ijms242316752
Access Level:acceso abierto
Palabra clave:ASC differentiation
Adipose-derived stem cells
Angiogenesis
Cell therapy
Critical limb ischemia
Peripheral artery disease
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spelling Adipose-Derived Stem Cells to Treat Ischemic DiseasesThe Case of Peripheral Artery DiseaseArderiu, Gemma|||0000-0001-8598-4106Civit-Urgell, Anna|||0000-0002-5804-8408Badimon, Lina|||0000-0002-9162-2459ASC differentiationAdipose-derived stem cellsAngiogenesisCell therapyCritical limb ischemiaPeripheral artery diseaseCritical limb ischemia incidence and prevalence have increased over the years. However, there are no successful treatments to improve quality of life and to reduce the risk of cardiovascular and limb events in these patients. Advanced regenerative therapies have focused their interest on the generation of new blood vessels to repair tissue damage through the use of stem cells. One of the most promising sources of stem cells with high potential in cell-based therapy is adipose-derived stem cells (ASCs). ASCs are adult mesenchymal stem cells that are relatively abundant and ubiquitous and are characterized by a multilineage capacity and low immunogenicity. The proangiogenic benefits of ASCs may be ascribed to: (a) paracrine secretion of proangiogenic molecules that may stimulate angiogenesis; (b) secretion of microvesicles/exosomes that are also considered as a novel therapeutic prospect for treating ischemic diseases; and (c) their differentiation capability toward endothelial cells (ECs). Although we know the proangiogenic effects of ASCs, the therapeutic efficacy of ASCs after transplantation in peripheral artery diseases patients is still relatively low. In this review, we evidence the potential therapeutic use of ASCs in ischemic regenerative medicine. We also highlight the main challenges in the differentiation of these cells into functional ECs. However, significant efforts are still needed to ascertain relevant transcription factors, intracellular signaling and interlinking pathways in endothelial differentiation.Universitat Autònoma de Barcelona 22023-01-0120232023-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/296599https://dx.doi.org/urn:doi:10.3390/ijms242316752reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-107160RB-I00Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CB16/11/00411Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01517open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2965992026-06-06T12:50:31Z
dc.title.none.fl_str_mv Adipose-Derived Stem Cells to Treat Ischemic Diseases
The Case of Peripheral Artery Disease
title Adipose-Derived Stem Cells to Treat Ischemic Diseases
spellingShingle Adipose-Derived Stem Cells to Treat Ischemic Diseases
Arderiu, Gemma|||0000-0001-8598-4106
ASC differentiation
Adipose-derived stem cells
Angiogenesis
Cell therapy
Critical limb ischemia
Peripheral artery disease
title_short Adipose-Derived Stem Cells to Treat Ischemic Diseases
title_full Adipose-Derived Stem Cells to Treat Ischemic Diseases
title_fullStr Adipose-Derived Stem Cells to Treat Ischemic Diseases
title_full_unstemmed Adipose-Derived Stem Cells to Treat Ischemic Diseases
title_sort Adipose-Derived Stem Cells to Treat Ischemic Diseases
dc.creator.none.fl_str_mv Arderiu, Gemma|||0000-0001-8598-4106
Civit-Urgell, Anna|||0000-0002-5804-8408
Badimon, Lina|||0000-0002-9162-2459
author Arderiu, Gemma|||0000-0001-8598-4106
author_facet Arderiu, Gemma|||0000-0001-8598-4106
Civit-Urgell, Anna|||0000-0002-5804-8408
Badimon, Lina|||0000-0002-9162-2459
author_role author
author2 Civit-Urgell, Anna|||0000-0002-5804-8408
Badimon, Lina|||0000-0002-9162-2459
author2_role author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv ASC differentiation
Adipose-derived stem cells
Angiogenesis
Cell therapy
Critical limb ischemia
Peripheral artery disease
topic ASC differentiation
Adipose-derived stem cells
Angiogenesis
Cell therapy
Critical limb ischemia
Peripheral artery disease
description Critical limb ischemia incidence and prevalence have increased over the years. However, there are no successful treatments to improve quality of life and to reduce the risk of cardiovascular and limb events in these patients. Advanced regenerative therapies have focused their interest on the generation of new blood vessels to repair tissue damage through the use of stem cells. One of the most promising sources of stem cells with high potential in cell-based therapy is adipose-derived stem cells (ASCs). ASCs are adult mesenchymal stem cells that are relatively abundant and ubiquitous and are characterized by a multilineage capacity and low immunogenicity. The proangiogenic benefits of ASCs may be ascribed to: (a) paracrine secretion of proangiogenic molecules that may stimulate angiogenesis; (b) secretion of microvesicles/exosomes that are also considered as a novel therapeutic prospect for treating ischemic diseases; and (c) their differentiation capability toward endothelial cells (ECs). Although we know the proangiogenic effects of ASCs, the therapeutic efficacy of ASCs after transplantation in peripheral artery diseases patients is still relatively low. In this review, we evidence the potential therapeutic use of ASCs in ischemic regenerative medicine. We also highlight the main challenges in the differentiation of these cells into functional ECs. However, significant efforts are still needed to ascertain relevant transcription factors, intracellular signaling and interlinking pathways in endothelial differentiation.
publishDate 2023
dc.date.none.fl_str_mv 2
2023-01-01
2023
2023-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/296599
https://dx.doi.org/urn:doi:10.3390/ijms242316752
url https://ddd.uab.cat/record/296599
https://dx.doi.org/urn:doi:10.3390/ijms242316752
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2019-107160RB-I00
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 CB16/11/00411
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI20/01517
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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