Transgenerational transmission of small for gestational age

Objective: To evaluate the transgenerational transmission of small for gestational age. Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational ag...

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Autores: Sepúlveda Martínez, Álvaro, Rodríguez López, Mérida, Paz y Miño, Fernanda, Casu, Giulia, Crovetto, Francesca, Gratacós Solsona, Eduard, Crispi Brillas, Fàtima
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/125607
Acceso en línea:https://hdl.handle.net/2445/125607
Access Level:acceso abierto
Palabra clave:Creixement fetal
Medicina prenatal
Fetal growth
Prenatal medicine
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spelling Transgenerational transmission of small for gestational ageSepúlveda Martínez, ÁlvaroRodríguez López, MéridaPaz y Miño, FernandaCasu, GiuliaCrovetto, FrancescaGratacós Solsona, EduardCrispi Brillas, FàtimaCreixement fetalMedicina prenatalFetal growthPrenatal medicineObjective: To evaluate the transgenerational transmission of small for gestational age. Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational age (SGA) and 80 with appropriate intrauterine growth) reported to have at least one child. Multiple regression analysis was used to determine the presence of SGA (defined as a birthweight < 10th percentile) or placental mediated disease (defined as the presence of SGA, preeclampsia or gestational hypertension) in the following generation. Results: Descendants from SGA adults presented lower birthweight percentile (median 26 [interquartile range 7-52] vs. 43 [19-75]; p<0.001) and higher prevalence of SGA (40.3% vs. 16.3%; p=0.001) and placental mediated disease (43.1% vs. 17.5%; p=0.001). After adjustment for confounder variables, parental SGA background was associated with an almost three-fold increased risk of subsequent SGA or any placental mediated disease in the following generation. This association was stronger in SGA mothers as compared to fathers. Conclusions: Our data provides evidence suggesting a transgenerational transmission of SGA highlighting the importance of public health strategies for preventing intrauterine growth impairment.John Wiley & Sons2018201920182018info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion28 p.application/pdfhttps://hdl.handle.net/2445/125607Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1002/uog.20119Ultrasound in Obstetrics & Gynecology, 2018https://doi.org/10.1002/uog.20119(c) International Society of Ultrasound in Obstetrics & Gynecology (ISUOG), 2018info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1256072026-05-29T05:05:01Z
dc.title.none.fl_str_mv Transgenerational transmission of small for gestational age
title Transgenerational transmission of small for gestational age
spellingShingle Transgenerational transmission of small for gestational age
Sepúlveda Martínez, Álvaro
Creixement fetal
Medicina prenatal
Fetal growth
Prenatal medicine
title_short Transgenerational transmission of small for gestational age
title_full Transgenerational transmission of small for gestational age
title_fullStr Transgenerational transmission of small for gestational age
title_full_unstemmed Transgenerational transmission of small for gestational age
title_sort Transgenerational transmission of small for gestational age
dc.creator.none.fl_str_mv Sepúlveda Martínez, Álvaro
Rodríguez López, Mérida
Paz y Miño, Fernanda
Casu, Giulia
Crovetto, Francesca
Gratacós Solsona, Eduard
Crispi Brillas, Fàtima
author Sepúlveda Martínez, Álvaro
author_facet Sepúlveda Martínez, Álvaro
Rodríguez López, Mérida
Paz y Miño, Fernanda
Casu, Giulia
Crovetto, Francesca
Gratacós Solsona, Eduard
Crispi Brillas, Fàtima
author_role author
author2 Rodríguez López, Mérida
Paz y Miño, Fernanda
Casu, Giulia
Crovetto, Francesca
Gratacós Solsona, Eduard
Crispi Brillas, Fàtima
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Creixement fetal
Medicina prenatal
Fetal growth
Prenatal medicine
topic Creixement fetal
Medicina prenatal
Fetal growth
Prenatal medicine
description Objective: To evaluate the transgenerational transmission of small for gestational age. Methods: Cohort study including a random sample of 2,043 offspring of deliveries occurring from 1975 to 1993. Of 623 offspring -now adults- that agreed to participate, 152 adults (72 born small-for-gestational age (SGA) and 80 with appropriate intrauterine growth) reported to have at least one child. Multiple regression analysis was used to determine the presence of SGA (defined as a birthweight < 10th percentile) or placental mediated disease (defined as the presence of SGA, preeclampsia or gestational hypertension) in the following generation. Results: Descendants from SGA adults presented lower birthweight percentile (median 26 [interquartile range 7-52] vs. 43 [19-75]; p<0.001) and higher prevalence of SGA (40.3% vs. 16.3%; p=0.001) and placental mediated disease (43.1% vs. 17.5%; p=0.001). After adjustment for confounder variables, parental SGA background was associated with an almost three-fold increased risk of subsequent SGA or any placental mediated disease in the following generation. This association was stronger in SGA mothers as compared to fathers. Conclusions: Our data provides evidence suggesting a transgenerational transmission of SGA highlighting the importance of public health strategies for preventing intrauterine growth impairment.
publishDate 2018
dc.date.none.fl_str_mv 2018
2018
2018
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/125607
url https://hdl.handle.net/2445/125607
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1002/uog.20119
Ultrasound in Obstetrics & Gynecology, 2018
https://doi.org/10.1002/uog.20119
dc.rights.none.fl_str_mv (c) International Society of Ultrasound in Obstetrics & Gynecology (ISUOG), 2018
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) International Society of Ultrasound in Obstetrics & Gynecology (ISUOG), 2018
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 28 p.
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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