Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studies

This review evaluates the effect of magnesium (Mg)-doped coatings on the osseointegration of titanium (Ti)-based implants. The recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the PRISMA 2020 Statement were followed, with registration in PROSPERO (CRD4202...

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Autores: Sigilião Celles, Cícero Andrade, Aparicio Bádenas, Conrado José|||0000-0003-2969-6067, Barão, Valentim Adelino Ricardo, Dini, Caroline|||0000-0002-2587-3137
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de Catalunya (UPC)
Repositorio:UPCommons. Portal del coneixement obert de la UPC
Idioma:inglés
OAI Identifier:oai:dnet:upcommonspor::b9b3170872f6c4fbfe0a680ae4e8b342
Acceso en línea:https://hdl.handle.net/2117/460384
https://dx.doi.org/10.1002/JBM.B.35681
Access Level:acceso abierto
Palabra clave:Bone–implant interface
Dental implants
Magnesium
Osseointegration
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spelling Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studiesSigilião Celles, Cícero AndradeAparicio Bádenas, Conrado José|||0000-0003-2969-6067Barão, Valentim Adelino RicardoDini, Caroline|||0000-0002-2587-3137Bone–implant interfaceDental implantsMagnesiumOsseointegrationThis review evaluates the effect of magnesium (Mg)-doped coatings on the osseointegration of titanium (Ti)-based implants. The recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the PRISMA 2020 Statement were followed, with registration in PROSPERO (CRD42024572571). The PICOS strategy was based on population: dental im- plants; intervention: Mg coatings; control: surfaces without Mg; outcomes: bone–implant contact (BIC), bone area (BA), implant stability coefficient (ISQ), and removal torque (RTQ); and study Design: in vivo studies. The SYRCLE tool was used to assess the risk of bias of animal studies. Meta-analyses were performed, using a random-effect model and 95% confidence interval. Twenty- three records were included, and 21 were enrolled in the meta-analyses. The most commonly used Mg doping method was microarc oxidation. The Mg-doped coatings, significantly favored pooled BIC values in animals [-6.09 (-8.35, -3.82), I2 : 50%, p < 0.00001], especially up to 3, 4, 6, and 8 weeks compared to surfaces without Mg. Interestingly, Mg-doped coatings favored BA up to 6 weeks [-8.20 (-14.31, -2.09), I2 : 0%, p = 0.008], and RTQ up to 3 [-8.44 (-12.33, -4.56), I2 : 63%, p < 0.0001]. Conversely, it did not influence ISQ [-0.24 (-2.05, 1.58), I2 : 88%, p = 0.80]. Mg-doped coatings significantly enhanced osseointegration in dental implants by improving BIC, BA, and RTQ, while showing no impact on ISQ. Supported by studies across various animal species, these results confirm that such coatings represent an effective and safe approach for promoting bone integration.This study was partially supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo (#2022/16267-5 to V.A.R.B., #2023/02180-8 to C.D., #2024/06635-2 to C.A.S.C.); the Conselho Nacional de Desenvolvimento Científico e Tecnologico (CNPq) (#307471/2021-7 to V.A.R.B.), and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance code 001). C.A. acknowledges financial support from the Ministerio de Ciencia e Innovación (MCIN/AEI/10.13039/501100011033) and from the European Social Fund (FSE+) through the project PREVENTITIS-PID2022-137496OB-I00.John Wiley & sons20252025-11-0120262026-04-10journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/2117/460384https://dx.doi.org/10.1002/JBM.B.35681reponame:UPCommons. Portal del coneixement obert de la UPCinstname:Universitat Politècnica de Catalunya (UPC)InglésengAgencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-137496OB-I00 INTERFACES Y MATERIALES BIOINSPIRADOS PARA LA PREVENCION DE INFECCIONES EN IMPLANTES TRANSEPITELIALESopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:dnet:upcommonspor::b9b3170872f6c4fbfe0a680ae4e8b3422026-05-27T15:37:01Z
dc.title.none.fl_str_mv Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studies
title Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studies
spellingShingle Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studies
Sigilião Celles, Cícero Andrade
Bone–implant interface
Dental implants
Magnesium
Osseointegration
title_short Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studies
title_full Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studies
title_fullStr Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studies
title_full_unstemmed Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studies
title_sort Magnesium-doped coatings as a suitable approach to improve osseointegration of titanium-based implants: a systematic review and meta-analyses of animal studies
dc.creator.none.fl_str_mv Sigilião Celles, Cícero Andrade
Aparicio Bádenas, Conrado José|||0000-0003-2969-6067
Barão, Valentim Adelino Ricardo
Dini, Caroline|||0000-0002-2587-3137
author Sigilião Celles, Cícero Andrade
author_facet Sigilião Celles, Cícero Andrade
Aparicio Bádenas, Conrado José|||0000-0003-2969-6067
Barão, Valentim Adelino Ricardo
Dini, Caroline|||0000-0002-2587-3137
author_role author
author2 Aparicio Bádenas, Conrado José|||0000-0003-2969-6067
Barão, Valentim Adelino Ricardo
Dini, Caroline|||0000-0002-2587-3137
author2_role author
author
author
dc.subject.none.fl_str_mv Bone–implant interface
Dental implants
Magnesium
Osseointegration
topic Bone–implant interface
Dental implants
Magnesium
Osseointegration
description This review evaluates the effect of magnesium (Mg)-doped coatings on the osseointegration of titanium (Ti)-based implants. The recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the PRISMA 2020 Statement were followed, with registration in PROSPERO (CRD42024572571). The PICOS strategy was based on population: dental im- plants; intervention: Mg coatings; control: surfaces without Mg; outcomes: bone–implant contact (BIC), bone area (BA), implant stability coefficient (ISQ), and removal torque (RTQ); and study Design: in vivo studies. The SYRCLE tool was used to assess the risk of bias of animal studies. Meta-analyses were performed, using a random-effect model and 95% confidence interval. Twenty- three records were included, and 21 were enrolled in the meta-analyses. The most commonly used Mg doping method was microarc oxidation. The Mg-doped coatings, significantly favored pooled BIC values in animals [-6.09 (-8.35, -3.82), I2 : 50%, p < 0.00001], especially up to 3, 4, 6, and 8 weeks compared to surfaces without Mg. Interestingly, Mg-doped coatings favored BA up to 6 weeks [-8.20 (-14.31, -2.09), I2 : 0%, p = 0.008], and RTQ up to 3 [-8.44 (-12.33, -4.56), I2 : 63%, p < 0.0001]. Conversely, it did not influence ISQ [-0.24 (-2.05, 1.58), I2 : 88%, p = 0.80]. Mg-doped coatings significantly enhanced osseointegration in dental implants by improving BIC, BA, and RTQ, while showing no impact on ISQ. Supported by studies across various animal species, these results confirm that such coatings represent an effective and safe approach for promoting bone integration.
publishDate 2025
dc.date.none.fl_str_mv 2025
2025-11-01
2026
2026-04-10
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/2117/460384
https://dx.doi.org/10.1002/JBM.B.35681
url https://hdl.handle.net/2117/460384
https://dx.doi.org/10.1002/JBM.B.35681
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación http://doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2021-2023 PID2022-137496OB-I00 INTERFACES Y MATERIALES BIOINSPIRADOS PARA LA PREVENCION DE INFECCIONES EN IMPLANTES TRANSEPITELIALES
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & sons
publisher.none.fl_str_mv John Wiley & sons
dc.source.none.fl_str_mv reponame:UPCommons. Portal del coneixement obert de la UPC
instname:Universitat Politècnica de Catalunya (UPC)
instname_str Universitat Politècnica de Catalunya (UPC)
reponame_str UPCommons. Portal del coneixement obert de la UPC
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