Primary Cilia as a Tumor Marker in Pituitary Neuroendocrine Tumors

Pituitary neuroendocrine tumors (PitNETs) account for approximately 15% of all intracranial neoplasms. Although they usually appear to be benign, some tumors display worse behavior, displaying rapid growth, invasion, refractoriness to treatment, and recurrence. Increasing evidence supports the role...

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Detalles Bibliográficos
Autores: Martínez Hernández, Rebeca, Serrano Somavilla, Ana, Fernández Contreras, Raul, Sanchez Guerrero, Cristina, Sánchez de la Blanca, Nuria, Sacristán Gómez, Pablo, Sebastián Valles, Fernando, Sampedro Núñez, Miguel Antonio, Fraga Fernández, Javier Germán, Calatayud, María, Vicente, Almudena, García de Casasola, Gonzalo, Sanz García, Ancor, Araujo Castro, Marta, Ruz Caracuel, Ignacio, Puig Domingo, Manel, Marazuela Azpiroz, Mónica
Tipo de recurso: artículo
Fecha de publicación:2024
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/714983
Acceso en línea:http://hdl.handle.net/10486/714983
https://dx.doi.org/10.1016/j.modpat.2024.100475
Access Level:acceso abierto
Palabra clave:ciliogenesis
pituitary neuroendocrine tumors
primary cilia
tumor marker
Medicina
Descripción
Sumario:Pituitary neuroendocrine tumors (PitNETs) account for approximately 15% of all intracranial neoplasms. Although they usually appear to be benign, some tumors display worse behavior, displaying rapid growth, invasion, refractoriness to treatment, and recurrence. Increasing evidence supports the role of primary cilia (PC) in regulating cancer development. Here, we showed that PC are significantly increased in PitNETs and are associated with increased tumor invasion and recurrence. Serial electron micrographs of PITNETs demonstrated different ciliation phenotypes (dot-like versus normal-like cilia) that represented PC at different stages of ciliogenesis. Molecular findings demonstrated that 123 ciliary-associated genes (eg, doublecortin domain containing protein 2, Sintaxin-3, and centriolar coiled-coil protein 110) were dysregulated in PitNETs, representing the upregulation of markers at different stages of intracellular ciliogenesis. Our results demonstrate, for the first time, that ciliogenesis is increased in PitNETs, suggesting that this process might be used as a potential target for therapy in the future

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