Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid Arthritis

INTRODUCTION: Rheumatoid arthritis is an inflammatory disease with high incidence of cardiovascular disease due to accelerated atherosclerosis. Osteoprotegerin (OPG) has been associated with increased risk of atherosclerotic disease in the general population. Several polymorphisms in the OPG gene wi...

Descripción completa

Detalles Bibliográficos
Autores: Genre, Fernanda, López Mejías, Raquel, García Bermúdez, Mercedes, Castañeda Sanz, Santos, González Juanatey, Carlos, Llorca Díaz, Francisco Javier|||0000-0001-8569-861X, Corrales Martínez, Alfonso, Ubilla García, Begoña, Miranda Filloy, José Alberto, Pina Murcia, Trinitario, Gómez Vaquero, Carmen, Rodríguez Rodríguez, Luis, Fernández Gutiérrez, Benjamín, Balsa Criado, Alejandro, Pascual Salcedo, Dora, López Longo, Francisco J., Carreira Delgado, Patricia, Blanco Alonso, Ricardo|||0000-0003-2344-2285, González Álvaro, Isidoro, Martín Ibáñez, Javier, González-Gay Mantecón, Miguel Ángel
Tipo de recurso: artículo
Fecha de publicación:2014
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/5313
Acceso en línea:http://hdl.handle.net/10902/5313
Access Level:acceso abierto
id ES_727f95efbb1fc2003c3bd6bb8f409553
oai_identifier_str oai:repositorio.unican.es:10902/5313
network_acronym_str ES
network_name_str España
repository_id_str
spelling Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid ArthritisGenre, FernandaLópez Mejías, RaquelGarcía Bermúdez, MercedesCastañeda Sanz, SantosGonzález Juanatey, CarlosLlorca Díaz, Francisco Javier|||0000-0001-8569-861XCorrales Martínez, AlfonsoUbilla García, BegoñaMiranda Filloy, José AlbertoPina Murcia, TrinitarioGómez Vaquero, CarmenRodríguez Rodríguez, LuisFernández Gutiérrez, BenjamínBalsa Criado, AlejandroPascual Salcedo, DoraLópez Longo, Francisco J.Carreira Delgado, PatriciaBlanco Alonso, Ricardo|||0000-0003-2344-2285González Álvaro, IsidoroMartín Ibáñez, JavierGonzález-Gay Mantecón, Miguel ÁngelINTRODUCTION: Rheumatoid arthritis is an inflammatory disease with high incidence of cardiovascular disease due to accelerated atherosclerosis. Osteoprotegerin (OPG) has been associated with increased risk of atherosclerotic disease in the general population. Several polymorphisms in the OPG gene with functional effects on cardiovascular disease in non-rheumatic individuals have been described. Therefore, we aimed to analyze the effect of three of these functional OPG polymorphisms on the risk of cardiovascular disease in a large and well-characterized cohort of Spanish patients with rheumatoid arthritis. METHODS: Three OPG gene variants (rs3134063, rs2073618 and rs3134069) were genotyped by TaqMan assays in 2027 Spanish patients with rheumatoid arthritis. Anti-cyclic citrullinated peptide (anti-CCP) antibody testing was positive in 997 of 1714 tested. Also, 18.3% of the whole series had experienced cardiovascular events, including 5.4% with cerebrovascular accidents. The relationship between OPG variants and cardiovascular events was assessed using Cox regression. RESULTS: No association between OPG gene variants and cardiovascular disease was observed in the whole group of rheumatoid arthritis patients or in anti-CCP positive patients. Nevertheless, a protective effect of CGA haplotype on the risk of cardiovascular disease in general, and specifically in the risk of cerebrovascular complications after adjusting for sex, age at disease diagnosis and traditional cardiovascular risk factors was disclosed in anti-CCP negative patients (HR = 0.54; 95%CI: 0.31-0.95; p = 0.032 and HR = 0.17; 95%CI: 0.04-0.78; p = 0.022, respectively). CONCLUSION: Our results indicate a protective effect of the OPG CGA haplotype on cardiovascular risk, mainly due to a protective effect against cerebrovascular events in anti-CCP negative rheumatoid arthritis patients.Public Library of ScienceUniversidad de Cantabria20142014-09-03journal articlehttp://purl.org/coar/resource_type/c_6501NAhttp://purl.org/coar/version/c_be7fb7dd8ff6fe43info:eu-repo/semantics/articlehttp://hdl.handle.net/10902/5313PLoS One. 2014 Sep 3;9(9):e106823reponame:UCrea Repositorio Abierto de la Universidad de Cantabriainstname:Universidad de Cantabria (UC)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:repositorio.unican.es:10902/53132026-06-02T12:39:31Z
dc.title.none.fl_str_mv Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid Arthritis
title Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid Arthritis
spellingShingle Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid Arthritis
Genre, Fernanda
title_short Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid Arthritis
title_full Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid Arthritis
title_fullStr Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid Arthritis
title_full_unstemmed Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid Arthritis
title_sort Osteoprotegerin CGA Haplotype Protection against Cerebrovascular Complications in Anti-CCP Negative Patients with Rheumatoid Arthritis
dc.creator.none.fl_str_mv Genre, Fernanda
López Mejías, Raquel
García Bermúdez, Mercedes
Castañeda Sanz, Santos
González Juanatey, Carlos
Llorca Díaz, Francisco Javier|||0000-0001-8569-861X
Corrales Martínez, Alfonso
Ubilla García, Begoña
Miranda Filloy, José Alberto
Pina Murcia, Trinitario
Gómez Vaquero, Carmen
Rodríguez Rodríguez, Luis
Fernández Gutiérrez, Benjamín
Balsa Criado, Alejandro
Pascual Salcedo, Dora
López Longo, Francisco J.
Carreira Delgado, Patricia
Blanco Alonso, Ricardo|||0000-0003-2344-2285
González Álvaro, Isidoro
Martín Ibáñez, Javier
González-Gay Mantecón, Miguel Ángel
author Genre, Fernanda
author_facet Genre, Fernanda
López Mejías, Raquel
García Bermúdez, Mercedes
Castañeda Sanz, Santos
González Juanatey, Carlos
Llorca Díaz, Francisco Javier|||0000-0001-8569-861X
Corrales Martínez, Alfonso
Ubilla García, Begoña
Miranda Filloy, José Alberto
Pina Murcia, Trinitario
Gómez Vaquero, Carmen
Rodríguez Rodríguez, Luis
Fernández Gutiérrez, Benjamín
Balsa Criado, Alejandro
Pascual Salcedo, Dora
López Longo, Francisco J.
Carreira Delgado, Patricia
Blanco Alonso, Ricardo|||0000-0003-2344-2285
González Álvaro, Isidoro
Martín Ibáñez, Javier
González-Gay Mantecón, Miguel Ángel
author_role author
author2 López Mejías, Raquel
García Bermúdez, Mercedes
Castañeda Sanz, Santos
González Juanatey, Carlos
Llorca Díaz, Francisco Javier|||0000-0001-8569-861X
Corrales Martínez, Alfonso
Ubilla García, Begoña
Miranda Filloy, José Alberto
Pina Murcia, Trinitario
Gómez Vaquero, Carmen
Rodríguez Rodríguez, Luis
Fernández Gutiérrez, Benjamín
Balsa Criado, Alejandro
Pascual Salcedo, Dora
López Longo, Francisco J.
Carreira Delgado, Patricia
Blanco Alonso, Ricardo|||0000-0003-2344-2285
González Álvaro, Isidoro
Martín Ibáñez, Javier
González-Gay Mantecón, Miguel Ángel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad de Cantabria
description INTRODUCTION: Rheumatoid arthritis is an inflammatory disease with high incidence of cardiovascular disease due to accelerated atherosclerosis. Osteoprotegerin (OPG) has been associated with increased risk of atherosclerotic disease in the general population. Several polymorphisms in the OPG gene with functional effects on cardiovascular disease in non-rheumatic individuals have been described. Therefore, we aimed to analyze the effect of three of these functional OPG polymorphisms on the risk of cardiovascular disease in a large and well-characterized cohort of Spanish patients with rheumatoid arthritis. METHODS: Three OPG gene variants (rs3134063, rs2073618 and rs3134069) were genotyped by TaqMan assays in 2027 Spanish patients with rheumatoid arthritis. Anti-cyclic citrullinated peptide (anti-CCP) antibody testing was positive in 997 of 1714 tested. Also, 18.3% of the whole series had experienced cardiovascular events, including 5.4% with cerebrovascular accidents. The relationship between OPG variants and cardiovascular events was assessed using Cox regression. RESULTS: No association between OPG gene variants and cardiovascular disease was observed in the whole group of rheumatoid arthritis patients or in anti-CCP positive patients. Nevertheless, a protective effect of CGA haplotype on the risk of cardiovascular disease in general, and specifically in the risk of cerebrovascular complications after adjusting for sex, age at disease diagnosis and traditional cardiovascular risk factors was disclosed in anti-CCP negative patients (HR = 0.54; 95%CI: 0.31-0.95; p = 0.032 and HR = 0.17; 95%CI: 0.04-0.78; p = 0.022, respectively). CONCLUSION: Our results indicate a protective effect of the OPG CGA haplotype on cardiovascular risk, mainly due to a protective effect against cerebrovascular events in anti-CCP negative rheumatoid arthritis patients.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-09-03
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
NA
http://purl.org/coar/version/c_be7fb7dd8ff6fe43
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10902/5313
url http://hdl.handle.net/10902/5313
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
http://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv PLoS One. 2014 Sep 3;9(9):e106823
reponame:UCrea Repositorio Abierto de la Universidad de Cantabria
instname:Universidad de Cantabria (UC)
instname_str Universidad de Cantabria (UC)
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
collection UCrea Repositorio Abierto de la Universidad de Cantabria
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410740097515520
score 15.301629

Similares en LA Referencia