Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks

Obesity is a main global health issue and an outstanding cause of morbidity and mortality predisposing to type 2 diabetes (T2DM) and cardiovascular diseases. Huge research efforts focused on gene expression, cellular signalling and metabolism in obesity have improved our understanding of these disor...

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Autores: Gómez-Serrano, María, Camafeita, Emilio, García-Santos, Eva, López, Juan, Vázquez, Jesus, Peral, Belen, Rubio Herrera, Miguel Ángel, Sánchez Pernaute, Andrés, Torres García, Antonio José
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/116127
Acceso en línea:https://hdl.handle.net/20.500.14352/116127
Access Level:acceso abierto
Palabra clave:616-056.25
Ciencias Biomédicas
32 Ciencias Médicas
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spelling Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarksGómez-Serrano, MaríaCamafeita, EmilioGarcía-Santos, EvaLópez, JuanVázquez, JesusPeral, BelenRubio Herrera, Miguel ÁngelSánchez Pernaute, AndrésTorres García, Antonio José616-056.25Ciencias Biomédicas32 Ciencias MédicasObesity is a main global health issue and an outstanding cause of morbidity and mortality predisposing to type 2 diabetes (T2DM) and cardiovascular diseases. Huge research efforts focused on gene expression, cellular signalling and metabolism in obesity have improved our understanding of these disorders; nevertheless, to bridge the gap between the regulation of gene expression and changes in signalling/metabolism, protein levels must be assessed. We have extensively analysed visceral adipose tissue from age-, T2DM- and gender-matched obese patients using high-throughput proteomics and systems biology methods to identify new biomarkers for the onset of T2DM in obesity, as well as to gain insight into the influence of aging and gender in these disorders. About 250 proteins showed significant abundance differences in the age, T2DM and gender comparisons. In diabetic patients, remarkable gender-specific hallmarks were discovered regarding redox status, immune response and adipose tissue accumulation. Both aging and T2DM processes were associated with mitochondrial remodelling, albeit through well-differentiated proteome changes. Systems biology analysis highlighted mitochondrial proteins that could play a key role in the age-dependent pathophysiology of T2DM. Our findings could serve as a framework for future research in Translational Medicine directed at improving the quality of life of obese patients.Universidad Complutense de Madrid20162016-05-1020162016-05-10journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/116127reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/1161272026-06-02T12:44:21Z
dc.title.none.fl_str_mv Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks
title Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks
spellingShingle Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks
Gómez-Serrano, María
616-056.25
Ciencias Biomédicas
32 Ciencias Médicas
title_short Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks
title_full Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks
title_fullStr Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks
title_full_unstemmed Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks
title_sort Proteome-wide alterations on adipose tissue from obese patients as age-, diabetes- and gender-specific hallmarks
dc.creator.none.fl_str_mv Gómez-Serrano, María
Camafeita, Emilio
García-Santos, Eva
López, Juan
Vázquez, Jesus
Peral, Belen
Rubio Herrera, Miguel Ángel
Sánchez Pernaute, Andrés
Torres García, Antonio José
author Gómez-Serrano, María
author_facet Gómez-Serrano, María
Camafeita, Emilio
García-Santos, Eva
López, Juan
Vázquez, Jesus
Peral, Belen
Rubio Herrera, Miguel Ángel
Sánchez Pernaute, Andrés
Torres García, Antonio José
author_role author
author2 Camafeita, Emilio
García-Santos, Eva
López, Juan
Vázquez, Jesus
Peral, Belen
Rubio Herrera, Miguel Ángel
Sánchez Pernaute, Andrés
Torres García, Antonio José
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 616-056.25
Ciencias Biomédicas
32 Ciencias Médicas
topic 616-056.25
Ciencias Biomédicas
32 Ciencias Médicas
description Obesity is a main global health issue and an outstanding cause of morbidity and mortality predisposing to type 2 diabetes (T2DM) and cardiovascular diseases. Huge research efforts focused on gene expression, cellular signalling and metabolism in obesity have improved our understanding of these disorders; nevertheless, to bridge the gap between the regulation of gene expression and changes in signalling/metabolism, protein levels must be assessed. We have extensively analysed visceral adipose tissue from age-, T2DM- and gender-matched obese patients using high-throughput proteomics and systems biology methods to identify new biomarkers for the onset of T2DM in obesity, as well as to gain insight into the influence of aging and gender in these disorders. About 250 proteins showed significant abundance differences in the age, T2DM and gender comparisons. In diabetic patients, remarkable gender-specific hallmarks were discovered regarding redox status, immune response and adipose tissue accumulation. Both aging and T2DM processes were associated with mitochondrial remodelling, albeit through well-differentiated proteome changes. Systems biology analysis highlighted mitochondrial proteins that could play a key role in the age-dependent pathophysiology of T2DM. Our findings could serve as a framework for future research in Translational Medicine directed at improving the quality of life of obese patients.
publishDate 2016
dc.date.none.fl_str_mv 2016
2016-05-10
2016
2016-05-10
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/116127
url https://hdl.handle.net/20.500.14352/116127
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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