Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction

Aims: Heart failure (HF) guidelines recommend treating all patients with HF and reduced ejection fraction (HFrEF) with quadruple therapy, although they do not establish how to start it. This study aimed to evaluate the implementation of these recommendations, analyzing the efficacy and safety of the...

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Autores: Esteban Fernández, Alberto, Gómez Otero, Inés, López Fernández, Silvia, Rodríguez Santamarta, Miguel, Pastor Pérez, Francisco J., Fluvià Brugués, Paula, López López, Andrea, García Pinilla, José Manuel, Juan Bagudá, Javier de, Ridocci Soriano, Francisco, TIDY-HF investigators, Et al.
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad Europea (UEM)
Repositorio:ABACUS. Repositorio de Producción Científica
Idioma:inglés
OAI Identifier:oai:abacus.universidadeuropea.com:11268/12410
Acceso en línea:http://hdl.handle.net/11268/12410
Access Level:acceso abierto
Palabra clave:Guía de práctica clínica
Insuficiencia cardíaca sistólica
Enfermedad cardiovascular
Medicina preventiva
Goal 3: Ensure healthy lives and promote well-being for all at all ages
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spelling Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fractionEsteban Fernández, AlbertoGómez Otero, InésLópez Fernández, SilviaRodríguez Santamarta, MiguelPastor Pérez, Francisco J.Fluvià Brugués, PaulaLópez López, AndreaGarcía Pinilla, José ManuelJuan Bagudá, Javier deRidocci Soriano, FranciscoTIDY-HF investigatorsEt al.Guía de práctica clínicaInsuficiencia cardíaca sistólicaEnfermedad cardiovascularMedicina preventivaGoal 3: Ensure healthy lives and promote well-being for all at all agesAims: Heart failure (HF) guidelines recommend treating all patients with HF and reduced ejection fraction (HFrEF) with quadruple therapy, although they do not establish how to start it. This study aimed to evaluate the implementation of these recommendations, analyzing the efficacy and safety of the different therapeutic schedules. Methods and results: Prospective, observational, and multicenter registry that evaluated the treatment initiated in patients with newly diagnosed HFrEF and its evolution at 3 months. Clinical and analytical data were collected, as well as adverse reactions and events during follow-up. Five hundred and thirty-three patients were included, selecting four hundred and ninety-seven, aged 65.5 ± 12.9 years (72% male). The most frequent etiologies were ischemic (25.5%) and idiopathic (21.1%), with a left ventricular ejection fraction of 28.7 ± 7.4%. Quadruple therapy was started in 314 (63.2%) patients, triple in 120 (24.1%), and double in 63 (12.7%). Follow-up was 112 days [IQI 91; 154], with 10 (2%) patients dying. At 3 months, 78.5% had quadruple therapy (p < 0.001). There were no differences in achieving maximum doses or reducing or withdrawing drugs (< 6%) depending on the starting scheme. Twenty-seven (5.7%) patients had any emergency room visits or admission for HF, less frequent in those with quadruple therapy (p = 0.02). Conclusion: It is possible to achieve quadruple therapy in patients with newly diagnosed HFrEF early. This strategy makes it possible to reduce admissions and visits to the emergency room for HF without associating a more significant reduction or withdrawal of drugs or significant difficulty in achieving the target doses.20232023-11-3020242024-01-0120242024-01-01journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articlehttp://hdl.handle.net/11268/12410reponame:ABACUS. Repositorio de Producción Científicainstname:Universidad Europea (UEM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:abacus.universidadeuropea.com:11268/124102026-06-11T12:41:27Z
dc.title.none.fl_str_mv Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction
title Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction
spellingShingle Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction
Esteban Fernández, Alberto
Guía de práctica clínica
Insuficiencia cardíaca sistólica
Enfermedad cardiovascular
Medicina preventiva
Goal 3: Ensure healthy lives and promote well-being for all at all ages
title_short Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction
title_full Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction
title_fullStr Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction
title_full_unstemmed Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction
title_sort Influence of the medical treatment schedule in new diagnoses patients with heart failure and reduced ejection fraction
dc.creator.none.fl_str_mv Esteban Fernández, Alberto
Gómez Otero, Inés
López Fernández, Silvia
Rodríguez Santamarta, Miguel
Pastor Pérez, Francisco J.
Fluvià Brugués, Paula
López López, Andrea
García Pinilla, José Manuel
Juan Bagudá, Javier de
Ridocci Soriano, Francisco
TIDY-HF investigators
Et al.
author Esteban Fernández, Alberto
author_facet Esteban Fernández, Alberto
Gómez Otero, Inés
López Fernández, Silvia
Rodríguez Santamarta, Miguel
Pastor Pérez, Francisco J.
Fluvià Brugués, Paula
López López, Andrea
García Pinilla, José Manuel
Juan Bagudá, Javier de
Ridocci Soriano, Francisco
TIDY-HF investigators
Et al.
author_role author
author2 Gómez Otero, Inés
López Fernández, Silvia
Rodríguez Santamarta, Miguel
Pastor Pérez, Francisco J.
Fluvià Brugués, Paula
López López, Andrea
García Pinilla, José Manuel
Juan Bagudá, Javier de
Ridocci Soriano, Francisco
TIDY-HF investigators
Et al.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Guía de práctica clínica
Insuficiencia cardíaca sistólica
Enfermedad cardiovascular
Medicina preventiva
Goal 3: Ensure healthy lives and promote well-being for all at all ages
topic Guía de práctica clínica
Insuficiencia cardíaca sistólica
Enfermedad cardiovascular
Medicina preventiva
Goal 3: Ensure healthy lives and promote well-being for all at all ages
description Aims: Heart failure (HF) guidelines recommend treating all patients with HF and reduced ejection fraction (HFrEF) with quadruple therapy, although they do not establish how to start it. This study aimed to evaluate the implementation of these recommendations, analyzing the efficacy and safety of the different therapeutic schedules. Methods and results: Prospective, observational, and multicenter registry that evaluated the treatment initiated in patients with newly diagnosed HFrEF and its evolution at 3 months. Clinical and analytical data were collected, as well as adverse reactions and events during follow-up. Five hundred and thirty-three patients were included, selecting four hundred and ninety-seven, aged 65.5 ± 12.9 years (72% male). The most frequent etiologies were ischemic (25.5%) and idiopathic (21.1%), with a left ventricular ejection fraction of 28.7 ± 7.4%. Quadruple therapy was started in 314 (63.2%) patients, triple in 120 (24.1%), and double in 63 (12.7%). Follow-up was 112 days [IQI 91; 154], with 10 (2%) patients dying. At 3 months, 78.5% had quadruple therapy (p < 0.001). There were no differences in achieving maximum doses or reducing or withdrawing drugs (< 6%) depending on the starting scheme. Twenty-seven (5.7%) patients had any emergency room visits or admission for HF, less frequent in those with quadruple therapy (p = 0.02). Conclusion: It is possible to achieve quadruple therapy in patients with newly diagnosed HFrEF early. This strategy makes it possible to reduce admissions and visits to the emergency room for HF without associating a more significant reduction or withdrawal of drugs or significant difficulty in achieving the target doses.
publishDate 2023
dc.date.none.fl_str_mv 2023
2023-11-30
2024
2024-01-01
2024
2024-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/11268/12410
url http://hdl.handle.net/11268/12410
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:ABACUS. Repositorio de Producción Científica
instname:Universidad Europea (UEM)
instname_str Universidad Europea (UEM)
reponame_str ABACUS. Repositorio de Producción Científica
collection ABACUS. Repositorio de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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