Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study
Endometriosis; Circulating endometrial cells; CD10
| Autores: | , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Departament de Salut de la Generalitat de Catalunya (DS) |
| Repositorio: | Scientia. Dipòsit d'Informació Digital del Departament de Salut |
| OAI Identifier: | oai:scientiasalut.gencat.cat:11351/4657 |
| Acceso en línea: | https://hdl.handle.net/11351/4657 |
| Access Level: | acceso abierto |
| Palabra clave: | Endometriosi Biòpsia DISEASES::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::Endometriosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Liquid Biopsy ENFERMEDADES::enfermedades de los genitales femeninos y complicaciones del embarazo::enfermedades urogenitales femeninas::enfermedades de los genitales femeninos::endometriosis TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia::biopsia líquida |
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Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot StudyVallvé Juanico, JúliaLópez Gil, CarlosBallesteros, AgustínSantamaria Costa, XavierEndometriosiBiòpsiaDISEASES::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::EndometriosisANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Liquid BiopsyENFERMEDADES::enfermedades de los genitales femeninos y complicaciones del embarazo::enfermedades urogenitales femeninas::enfermedades de los genitales femeninos::endometriosisTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia::biopsia líquidaEndometriosis; Circulating endometrial cells; CD10Endometriosis; Células endometriales circulantes; CD10Endometriosi; Cèl·lules endometrials circulants; CD10Endometriosis is characterized by the presence of endometrial tissue outside the uterus. While endometriotic tissue is commonly localized in the pelvic cavity, it can also be found in distant sites, including the brain. The origin and pathophysiology of tissue migration is poorly understood; retrograde menstruation is thought to be the cause, although the presence of endometrium at distant sites is not explained by this hypothesis. To determine whether dissemination occurs via the bloodstream in women with endometriosis, we analyzed circulating blood for the presence of endometrial cells. Circulating endometrial stromal cells were identified only in women with endometriosis but not in controls, while endometrial epithelial cells were not identified in the circulation of either group. Our results support the hypothesis that endometrial stromal cells may migrate through circulation and promote the pathophysiology of endometriosis. The detection of these cells in circulation creates avenues for the development of less invasive diagnostic tools for the disease, and opens possibilities for further study of the origin of endometriosis.This research was funded by a Centro de Desarrollo Tecnologico Industrial (CDTI) grant (IDI-2013039). The Industrial Doctorate AGAUR (Agency for Administration of University and Research Grants, Catalonia, Spain) also supported this work (DI2015_ 074)MDPI[Vallvé-Juanico J] Servei de Medicina Reproductiva, IVIRMA-Barcelon, Barcelona, Spain. Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Hospital Universitari Vall d’Hebron, Barcelona, Spain. Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, USA. [López-Gil C] Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Hospital Universitari Vall d’Hebron, Barcelona, Spain. [Ballesteros A] Servei de Medicina Reproductiva, IVIRMA-Barcelona, Barcelona, Spain. [Santamaria X] Servei de Medicina Reproductiva, IVIRMA-Barcelona, Barcelona, Spain. Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Hospital Universitari Vall d’Hebron, Barcelona, Spain. Igenomix Foundation, Paterna, SpainVall d'Hebron Barcelona Hospital Campus202020202019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/4657Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésInternational Journal of Molecular Sciences;20(15)https://www.mdpi.com/1422-0067/20/15/3740#Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/46572026-06-12T09:38:37Z |
| dc.title.none.fl_str_mv |
Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study |
| title |
Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study |
| spellingShingle |
Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study Vallvé Juanico, Júlia Endometriosi Biòpsia DISEASES::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::Endometriosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Liquid Biopsy ENFERMEDADES::enfermedades de los genitales femeninos y complicaciones del embarazo::enfermedades urogenitales femeninas::enfermedades de los genitales femeninos::endometriosis TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia::biopsia líquida |
| title_short |
Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study |
| title_full |
Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study |
| title_fullStr |
Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study |
| title_full_unstemmed |
Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study |
| title_sort |
Endometrial Stromal Cells Circulate in the Bloodstream of Women with Endometriosis: A Pilot Study |
| dc.creator.none.fl_str_mv |
Vallvé Juanico, Júlia López Gil, Carlos Ballesteros, Agustín Santamaria Costa, Xavier |
| author |
Vallvé Juanico, Júlia |
| author_facet |
Vallvé Juanico, Júlia López Gil, Carlos Ballesteros, Agustín Santamaria Costa, Xavier |
| author_role |
author |
| author2 |
López Gil, Carlos Ballesteros, Agustín Santamaria Costa, Xavier |
| author2_role |
author author author |
| dc.contributor.none.fl_str_mv |
[Vallvé-Juanico J] Servei de Medicina Reproductiva, IVIRMA-Barcelon, Barcelona, Spain. Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Hospital Universitari Vall d’Hebron, Barcelona, Spain. Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, USA. [López-Gil C] Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Hospital Universitari Vall d’Hebron, Barcelona, Spain. [Ballesteros A] Servei de Medicina Reproductiva, IVIRMA-Barcelona, Barcelona, Spain. [Santamaria X] Servei de Medicina Reproductiva, IVIRMA-Barcelona, Barcelona, Spain. Recerca Biomèdica en Ginecologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Hospital Universitari Vall d’Hebron, Barcelona, Spain. Igenomix Foundation, Paterna, Spain Vall d'Hebron Barcelona Hospital Campus |
| dc.subject.none.fl_str_mv |
Endometriosi Biòpsia DISEASES::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::Endometriosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Liquid Biopsy ENFERMEDADES::enfermedades de los genitales femeninos y complicaciones del embarazo::enfermedades urogenitales femeninas::enfermedades de los genitales femeninos::endometriosis TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia::biopsia líquida |
| topic |
Endometriosi Biòpsia DISEASES::Female Urogenital Diseases and Pregnancy Complications::Female Urogenital Diseases::Genital Diseases, Female::Endometriosis ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Cytological Techniques::Cytodiagnosis::Biopsy::Liquid Biopsy ENFERMEDADES::enfermedades de los genitales femeninos y complicaciones del embarazo::enfermedades urogenitales femeninas::enfermedades de los genitales femeninos::endometriosis TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::técnicas y procedimientos diagnósticos::técnicas de laboratorio clínico::técnicas citológicas::citodiagnóstico::biopsia::biopsia líquida |
| description |
Endometriosis; Circulating endometrial cells; CD10 |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019 2020 2020 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://hdl.handle.net/11351/4657 |
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https://hdl.handle.net/11351/4657 |
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Inglés |
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Inglés |
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International Journal of Molecular Sciences;20(15) https://www.mdpi.com/1422-0067/20/15/3740# |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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Scientia reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut instname:Departament de Salut de la Generalitat de Catalunya (DS) |
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Departament de Salut de la Generalitat de Catalunya (DS) |
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Scientia. Dipòsit d'Informació Digital del Departament de Salut |
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15.81155 |