Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort

BACKGROUND: Few studies have used longitudinal ultrasound measurements to assess the effect of traffic-related air pollution on fetal growth. OBJECTIVE: We examined the relationship between exposure to nitrogen dioxide (NO(2)) and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, an...

Descripción completa

Detalles Bibliográficos
Autores: Aguilera, Inmaculada, Garcia-Esteban, Raquel, Iniguez, Carmen, Nieuwenhuijsen, Mark J., Rodriguez, Agueda, Paez, Montserrat, Ballester, Ferran, Sunyer, Jordi
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:España
Institución:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
Repositorio:r-FISABIO. Repositorio Institucional de Producción Científica
OAI Identifier:oai:fisabio.fundanetsuite.com:p4124
Acceso en línea:https://fisabio.portalinvestigacion.com/publicaciones/4124
Access Level:acceso abierto
id ES_7201a63ab4e148fcf1dd0adaf60e7e73
oai_identifier_str oai:fisabio.fundanetsuite.com:p4124
network_acronym_str ES
network_name_str España
repository_id_str
spelling Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell CohortAguilera, InmaculadaGarcia-Esteban, RaquelIniguez, CarmenNieuwenhuijsen, Mark J.Rodriguez, AguedaPaez, MontserratBallester, FerranSunyer, JordiBACKGROUND: Few studies have used longitudinal ultrasound measurements to assess the effect of traffic-related air pollution on fetal growth. OBJECTIVE: We examined the relationship between exposure to nitrogen dioxide (NO(2)) and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX)] on fetal growth assessed by 1,692 ultrasound measurements among 562 pregnant women from the Sabadell cohort of the Spanish INMA (Environment and Childhood) study. METHODS: We used temporally adjusted land-use regression models to estimate exposures to NO(2) and BTEX. We fitted mixed-effects models to estimate longitudinal growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW). Unconditional and conditional SD scores were calculated at 12, 20, and 32 weeks of gestation. Sensitivity analyses were performed considering time-activity patterns during pregnancy. RESULTS: Exposure to BTEX from early pregnancy was negatively associated with growth in BPD during weeks 20-32. None of the other fetal growth parameters were associated with exposure to air pollution during pregnancy. When considering only women who spent < 2 hr/day in nonresidential outdoor locations, effect estimates were stronger and statistically significant for the association between NO(2) and growth in HC during weeks 12-20 and growth in AC, BPD, and EFW during weeks 20-32. CONCLUSIONS: Our results lend some support to an effect of exposure to traffic-related air pollutants from early pregnancy on fetal growth during mid-pregnancy.US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE2010info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fisabio.portalinvestigacion.com/publicaciones/4124ENVIRONMENTAL HEALTH PERSPECTIVESISSN: 00916765ISSNe: 15529924reponame:r-FISABIO. Repositorio Institucional de Producción Científicainstname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)Inglésinfo:eu-repo/semantics/openAccessoai:fisabio.fundanetsuite.com:p41242026-06-11T12:45:17Z
dc.title.none.fl_str_mv Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
spellingShingle Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
Aguilera, Inmaculada
title_short Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title_full Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title_fullStr Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title_full_unstemmed Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
title_sort Prenatal Exposure to Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth in the INMA Sabadell Cohort
dc.creator.none.fl_str_mv Aguilera, Inmaculada
Garcia-Esteban, Raquel
Iniguez, Carmen
Nieuwenhuijsen, Mark J.
Rodriguez, Agueda
Paez, Montserrat
Ballester, Ferran
Sunyer, Jordi
author Aguilera, Inmaculada
author_facet Aguilera, Inmaculada
Garcia-Esteban, Raquel
Iniguez, Carmen
Nieuwenhuijsen, Mark J.
Rodriguez, Agueda
Paez, Montserrat
Ballester, Ferran
Sunyer, Jordi
author_role author
author2 Garcia-Esteban, Raquel
Iniguez, Carmen
Nieuwenhuijsen, Mark J.
Rodriguez, Agueda
Paez, Montserrat
Ballester, Ferran
Sunyer, Jordi
author2_role author
author
author
author
author
author
author
description BACKGROUND: Few studies have used longitudinal ultrasound measurements to assess the effect of traffic-related air pollution on fetal growth. OBJECTIVE: We examined the relationship between exposure to nitrogen dioxide (NO(2)) and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX)] on fetal growth assessed by 1,692 ultrasound measurements among 562 pregnant women from the Sabadell cohort of the Spanish INMA (Environment and Childhood) study. METHODS: We used temporally adjusted land-use regression models to estimate exposures to NO(2) and BTEX. We fitted mixed-effects models to estimate longitudinal growth curves for femur length (FL), head circumference (HC), abdominal circumference (AC), biparietal diameter (BPD), and estimated fetal weight (EFW). Unconditional and conditional SD scores were calculated at 12, 20, and 32 weeks of gestation. Sensitivity analyses were performed considering time-activity patterns during pregnancy. RESULTS: Exposure to BTEX from early pregnancy was negatively associated with growth in BPD during weeks 20-32. None of the other fetal growth parameters were associated with exposure to air pollution during pregnancy. When considering only women who spent < 2 hr/day in nonresidential outdoor locations, effect estimates were stronger and statistically significant for the association between NO(2) and growth in HC during weeks 12-20 and growth in AC, BPD, and EFW during weeks 20-32. CONCLUSIONS: Our results lend some support to an effect of exposure to traffic-related air pollutants from early pregnancy on fetal growth during mid-pregnancy.
publishDate 2010
dc.date.none.fl_str_mv 2010
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fisabio.portalinvestigacion.com/publicaciones/4124
url https://fisabio.portalinvestigacion.com/publicaciones/4124
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
publisher.none.fl_str_mv US DEPT HEALTH HUMAN SCIENCES PUBLIC HEALTH SCIENCE
dc.source.none.fl_str_mv ENVIRONMENTAL HEALTH PERSPECTIVES
ISSN: 00916765
ISSNe: 15529924
reponame:r-FISABIO. Repositorio Institucional de Producción Científica
instname:Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
instname_str Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO)
reponame_str r-FISABIO. Repositorio Institucional de Producción Científica
collection r-FISABIO. Repositorio Institucional de Producción Científica
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869410693332074496
score 15,811543

Similares en LA Referencia