Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer

Despite significant advancements in early detection and treatment, non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. Specifically, in early-stage cases, recurrence after surgery continues to be the principal cause of death for these patients. The urgent need for...

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Autores: He, Y., Altuna-Coy, A.|||0000-0001-6544-3759, Acosta-Plasencia, M., Molins, Laureano|||0000-0001-6978-2715, Sánchez Lorente, David|||0000-0003-3308-4696, Martinez, Daniel, Díaz, T., Na, R., Marrades, Ramón M.|||0000-0001-9724-931X, Navarro, Alfons|||0000-0001-6071-0926
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:319544
Acceso en línea:https://ddd.uab.cat/record/319544
https://dx.doi.org/urn:doi:10.3390/ijms26072870
Access Level:acceso abierto
Palabra clave:NSCLC
Biomarkers
PiRNA
Prognosis
Recurrence
Squamous cell carcinoma
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spelling Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung CancerImplications for Recurrence and Survival in Squamous Cell Carcinoma PatientsHe, Y.Altuna-Coy, A.|||0000-0001-6544-3759Acosta-Plasencia, M.Molins, Laureano|||0000-0001-6978-2715Sánchez Lorente, David|||0000-0003-3308-4696Martinez, DanielDíaz, T.Na, R.Marrades, Ramón M.|||0000-0001-9724-931XNavarro, Alfons|||0000-0001-6071-0926NSCLCBiomarkersPiRNAPrognosisRecurrenceSquamous cell carcinomaDespite significant advancements in early detection and treatment, non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. Specifically, in early-stage cases, recurrence after surgery continues to be the principal cause of death for these patients. The urgent need for novel diagnostic and prognostic biomarkers has directed attention towards PIWI-interacting RNAs (piRNAs), a group of small RNAs that regulate genomic stability and epigenetics. Some piRNAs, including hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840, have been described as deregulated in various cancers. This study investigated the expression of these three piRNAs by RT-qPCR in 277 NSCLC patients and developed survival and CART classification models to predict recurrence risk, overall survival (OS), and disease-free survival (DFS). hsa_piR_019822 and hsa_piR_020840 were able to discriminate between tumor and normal tissue, as well as between adenocarcinoma and squamous cell carcinoma (LUSC) patients. Elevated expression of hsa_piR_019822 and hsa_piR_022710 was correlated with an increased risk of recurrence and poorer DFS and OS in LUSC patients. Patients with high hsa_piR_022710 expression more greatly benefited from adjuvant treatment. In summary, higher piRNA levels were associated with an increased risk of recurrence and poorer survival outcomes, especially in LUSC patients, where they may help guide personalized treatment strategies.Universitat Autònoma de Barcelona 22025-01-0120252025-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/319544https://dx.doi.org/urn:doi:10.3390/ijms26072870reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-88606-Popen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3195442026-06-06T12:50:31Z
dc.title.none.fl_str_mv Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer
Implications for Recurrence and Survival in Squamous Cell Carcinoma Patients
title Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer
spellingShingle Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer
He, Y.
NSCLC
Biomarkers
PiRNA
Prognosis
Recurrence
Squamous cell carcinoma
title_short Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer
title_full Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer
title_fullStr Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer
title_full_unstemmed Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer
title_sort Diagnostic and Prognostic Value of hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840 in Early-Stage Non-Small-Cell Lung Cancer
dc.creator.none.fl_str_mv He, Y.
Altuna-Coy, A.|||0000-0001-6544-3759
Acosta-Plasencia, M.
Molins, Laureano|||0000-0001-6978-2715
Sánchez Lorente, David|||0000-0003-3308-4696
Martinez, Daniel
Díaz, T.
Na, R.
Marrades, Ramón M.|||0000-0001-9724-931X
Navarro, Alfons|||0000-0001-6071-0926
author He, Y.
author_facet He, Y.
Altuna-Coy, A.|||0000-0001-6544-3759
Acosta-Plasencia, M.
Molins, Laureano|||0000-0001-6978-2715
Sánchez Lorente, David|||0000-0003-3308-4696
Martinez, Daniel
Díaz, T.
Na, R.
Marrades, Ramón M.|||0000-0001-9724-931X
Navarro, Alfons|||0000-0001-6071-0926
author_role author
author2 Altuna-Coy, A.|||0000-0001-6544-3759
Acosta-Plasencia, M.
Molins, Laureano|||0000-0001-6978-2715
Sánchez Lorente, David|||0000-0003-3308-4696
Martinez, Daniel
Díaz, T.
Na, R.
Marrades, Ramón M.|||0000-0001-9724-931X
Navarro, Alfons|||0000-0001-6071-0926
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv NSCLC
Biomarkers
PiRNA
Prognosis
Recurrence
Squamous cell carcinoma
topic NSCLC
Biomarkers
PiRNA
Prognosis
Recurrence
Squamous cell carcinoma
description Despite significant advancements in early detection and treatment, non-small-cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality. Specifically, in early-stage cases, recurrence after surgery continues to be the principal cause of death for these patients. The urgent need for novel diagnostic and prognostic biomarkers has directed attention towards PIWI-interacting RNAs (piRNAs), a group of small RNAs that regulate genomic stability and epigenetics. Some piRNAs, including hsa_piR_022710, hsa_piR_019822, and hsa_piR_020840, have been described as deregulated in various cancers. This study investigated the expression of these three piRNAs by RT-qPCR in 277 NSCLC patients and developed survival and CART classification models to predict recurrence risk, overall survival (OS), and disease-free survival (DFS). hsa_piR_019822 and hsa_piR_020840 were able to discriminate between tumor and normal tissue, as well as between adenocarcinoma and squamous cell carcinoma (LUSC) patients. Elevated expression of hsa_piR_019822 and hsa_piR_022710 was correlated with an increased risk of recurrence and poorer DFS and OS in LUSC patients. Patients with high hsa_piR_022710 expression more greatly benefited from adjuvant treatment. In summary, higher piRNA levels were associated with an increased risk of recurrence and poorer survival outcomes, especially in LUSC patients, where they may help guide personalized treatment strategies.
publishDate 2025
dc.date.none.fl_str_mv 2
2025-01-01
2025
2025-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/319544
https://dx.doi.org/urn:doi:10.3390/ijms26072870
url https://ddd.uab.cat/record/319544
https://dx.doi.org/urn:doi:10.3390/ijms26072870
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 SAF2017-88606-P
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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