Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity

Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer's disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since they should protect against Aβ neurotoxicity. We have studied the effects...

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Autores: Gallego-Villarejo, Lucía|||0000-0002-4219-8997, Wallin, C., Król, S., Enrich-Bengoa, Jennifer|||0000-0002-0840-4005, Suades, Albert, Aguilella-Arzo, Marcel|||0000-0002-2831-455X, Gómara Elena, María José, Haro, Immaculada, Wärmlander, S., Muñoz, Francisco J., Gräslund, A., Peralvarez-Marin, Alex|||0000-0002-3457-0875
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:292093
Acceso en línea:https://ddd.uab.cat/record/292093
https://dx.doi.org/urn:doi:10.1016/j.csbj.2022.10.014
Access Level:acceso abierto
Palabra clave:Alzheimer's disease
Amyloid β-peptide
Biophysics
Dynorphins
Peptide therapy
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spelling Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicityGallego-Villarejo, Lucía|||0000-0002-4219-8997Wallin, C.Król, S.Enrich-Bengoa, Jennifer|||0000-0002-0840-4005Suades, AlbertAguilella-Arzo, Marcel|||0000-0002-2831-455XGómara Elena, María JoséHaro, ImmaculadaWärmlander, S.Muñoz, Francisco J.Gräslund, A.Peralvarez-Marin, Alex|||0000-0002-3457-0875Alzheimer's diseaseAmyloid β-peptideBiophysicsDynorphinsPeptide therapyAmyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer's disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since they should protect against Aβ neurotoxicity. We have studied the effects of the interaction of dynorphins, a family of opioid neuropeptides, with Aβ the most abundant species of Aβ. Biophysical measurements indicate that Aβ interacts with Big Dynorphin (BigDyn), lowering the amount of hydrophobic aggregates, and slowing down the aggregation kinetics. As expected, we found that BigDyn protects against Aβ aggregates when studied in human neuroblastoma cells by cell survival assays. The cross-interaction between BigDyn and Aβ provides insight into the mechanism of amyloid pathophysiology and may open up new therapy possibilities. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/292093https://dx.doi.org/urn:doi:10.1016/j.csbj.2022.10.014reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengAgencia Estatal de Investigación https://doi.org/10.13039/501100011033 2019-108434GB-I00Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-120222GB-I00open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2920932026-06-06T12:50:31Z
dc.title.none.fl_str_mv Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
title Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
spellingShingle Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
Gallego-Villarejo, Lucía|||0000-0002-4219-8997
Alzheimer's disease
Amyloid β-peptide
Biophysics
Dynorphins
Peptide therapy
title_short Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
title_full Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
title_fullStr Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
title_full_unstemmed Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
title_sort Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
dc.creator.none.fl_str_mv Gallego-Villarejo, Lucía|||0000-0002-4219-8997
Wallin, C.
Król, S.
Enrich-Bengoa, Jennifer|||0000-0002-0840-4005
Suades, Albert
Aguilella-Arzo, Marcel|||0000-0002-2831-455X
Gómara Elena, María José
Haro, Immaculada
Wärmlander, S.
Muñoz, Francisco J.
Gräslund, A.
Peralvarez-Marin, Alex|||0000-0002-3457-0875
author Gallego-Villarejo, Lucía|||0000-0002-4219-8997
author_facet Gallego-Villarejo, Lucía|||0000-0002-4219-8997
Wallin, C.
Król, S.
Enrich-Bengoa, Jennifer|||0000-0002-0840-4005
Suades, Albert
Aguilella-Arzo, Marcel|||0000-0002-2831-455X
Gómara Elena, María José
Haro, Immaculada
Wärmlander, S.
Muñoz, Francisco J.
Gräslund, A.
Peralvarez-Marin, Alex|||0000-0002-3457-0875
author_role author
author2 Wallin, C.
Król, S.
Enrich-Bengoa, Jennifer|||0000-0002-0840-4005
Suades, Albert
Aguilella-Arzo, Marcel|||0000-0002-2831-455X
Gómara Elena, María José
Haro, Immaculada
Wärmlander, S.
Muñoz, Francisco J.
Gräslund, A.
Peralvarez-Marin, Alex|||0000-0002-3457-0875
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Alzheimer's disease
Amyloid β-peptide
Biophysics
Dynorphins
Peptide therapy
topic Alzheimer's disease
Amyloid β-peptide
Biophysics
Dynorphins
Peptide therapy
description Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer's disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since they should protect against Aβ neurotoxicity. We have studied the effects of the interaction of dynorphins, a family of opioid neuropeptides, with Aβ the most abundant species of Aβ. Biophysical measurements indicate that Aβ interacts with Big Dynorphin (BigDyn), lowering the amount of hydrophobic aggregates, and slowing down the aggregation kinetics. As expected, we found that BigDyn protects against Aβ aggregates when studied in human neuroblastoma cells by cell survival assays. The cross-interaction between BigDyn and Aβ provides insight into the mechanism of amyloid pathophysiology and may open up new therapy possibilities.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/292093
https://dx.doi.org/urn:doi:10.1016/j.csbj.2022.10.014
url https://ddd.uab.cat/record/292093
https://dx.doi.org/urn:doi:10.1016/j.csbj.2022.10.014
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 2019-108434GB-I00
Agencia Estatal de Investigación https://doi.org/10.13039/501100011033 PID2020-120222GB-I00
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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